Precision Medicine
Precision Public Health and Precision Medicine: An Evolving Relationship - March 2, 2015
New CDC blog post: Precision public health and precision medicine: two peas in a pod
CDC Advanced Molecular Detection infectious disease initiative
Will improve the ability of public health to detect outbreaks sooner and respond more effectively, saving lives and reducing cost
Will improve the ability of public health to detect outbreaks sooner and respond more effectively, saving lives and reducing cost
We screen newborns, don't we?: realizing the promise of public health genomics.
Evans James P et al. Genet. Med. 2013 May (5) 332-4
Evans James P et al. Genet. Med. 2013 May (5) 332-4
Precision medicine: Not just "genes, drugs, and disease", by William Riley, OBSSR, February 2, 2015
Medicine. Big data meets public health.
Khoury Muin J et al. Science 2014 Nov 28. (6213) 1054-5
Khoury Muin J et al. Science 2014 Nov 28. (6213) 1054-5
CDC National Biomonitoring Program
Assesses nutritional status and the exposure of the U.S. population to environmental chemicals and toxic substances
Assesses nutritional status and the exposure of the U.S. population to environmental chemicals and toxic substances
Precision Medicine: Building a Cohort of 1 Million People - February 17, 2015
Workshop Presentation Slides: Building a Large U.S. Research Cohort
Precision Medicine Initiative
Precision Medicine Initiative
Participant Engagement, Data Privacy, and Novel Ways of Returning Information to Participants [PDF 152 KB]
Opportunities and Challenges Related to the Use of Electronic Health Records Data for Research [PDF 184 KB]
FDA outlines plan for expected $10M under President's Precision Medicine Plan, Genome Web, Feb 18 [by free subscription only]
Precision Medicine: Insights on Benefits, Harms & Costs - February 9, 2015
Genomics, the data revolution, and health economics - the 2015 Astellas Innovation Debate, BMJ Blog Post, James Buchanan, February 2, 2015
Precision medicine is already working to cure Americans: These are their stories, by Lindsay Holst, White House Blog Post, Jan 30
The high price of precision healthcare, Joseph Guinto, Genome Magazine, January 2015
Big precision medicine plan raises patient privacy concerns, Scientific American, Feb 3
The problem with precision medicine, by Cynthia Graber , New Yorker, Feb 5
Moving precision medicine beyond the hype, Genome Web, Feb 6 [by free subscription only]
Precision medicine: Friend or foe? By David May, ACC in Touch Blog, Feb 6
Medicine just for you, by the Editorial Board, New York Times, Feb 7
More on Precision Medicine: Building a Cohort Consortium - February 2, 2015
Precision medicine initiative and cancer research, by Harold Varmus, NCI, Jan 30
The NCI Cohort Consortium
New models for large prospective studies: is there a better way?
Manolio TA, et al. Am J Epidemiol. 2012
New models for large prospective studies: is there a better way?
Manolio TA, et al. Am J Epidemiol. 2012
Precision medicine may never be very precise - but it may be good for public health, by Jeff Leek, SImPLYSTATS, Jan 30
Precision Medicine: Public Health Perspectives - January 30, 2015
Fact sheet: President Obama’s Precision Medicine Initiative, the White House, Jan 30
President Obama versus the naysayers: A big week for "precision" medicine, by Mark Wanner, Jackson Laboratory, Jan 30
A new initiative on precision medicine
Francis S. Collins and Harold Varmus, New England Journal of Medicine January 30, 2015
Francis S. Collins and Harold Varmus, New England Journal of Medicine January 30, 2015
The Precision Medicine Initiative: Data-driven treatments as unique as your own body, Linsay Holtz, the White House, Jan 30
NIH information: the Precision Medicine Initiative
New CDC blog post: The success of precision medicine requires a public health perspective
CDC paper: A population approach to precision medicine.
Khoury MJ, et al. Am J Prev Med.
Khoury MJ, et al. Am J Prev Med.
CDC paper: The public health role in translating advances in genomics.
Khoury MJ, Bowen S. Clinical Omics, August 13, 2014
Khoury MJ, Bowen S. Clinical Omics, August 13, 2014
Precision medicine: Improving health and treating disease, by Jo Handelsman, Associate Director for Science at the White House Office of Science and Technology, HHS Blog, Jan 22
US President launches ‘precision medicine’ initiative, The Pharmaceutical Journal, Jan 23
Obama to request research funding for treatments tailored to patients’ DNA, New York Times, Jan 24
Obama precision medicine plan would create huge U.S. genetic biobank, by Jocelyn Kaiser, Science Magazine, Jan 29
Precision Medicine: Cancer and Genomics - January 21, 2015
What is “precision medicine? Information from the National Cancer Institute
Impact of cancer genomics on precision medicine for the treatment of cancer, from the Cancer Genome Atlas, NCI
US precision-medicine proposal sparks questions, by Sara Reardon, Nature News, Jan 22
Obama's 'precision medicine' means gene mapping, NBC News, Jan 21
What is President Obama's 'precision medicine' plan, and how might it help you? By Lenny Bernstein, Jan 21
Obama proposes new Precision Medicine Initiative for genetic treatments, by Russell Brandom, The Verge, Jan 20
U.S. developing large-scale genomics project, Biocentury, Jan 16
Recent reviews
Companion diagnostics: the key to personalized medicine.
Jørgensen JT. Expert Rev Mol Diagn. 2015 Feb;15(2):153-6
Jørgensen JT. Expert Rev Mol Diagn. 2015 Feb;15(2):153-6
Promoting precision cancer medicine through a community-driven knowledgebase.
Geifman N, et al. J Pers Med. 2014 Dec 15;4(4):475-88.
Geifman N, et al. J Pers Med. 2014 Dec 15;4(4):475-88.
Toward a prostate cancer precision medicine.
Rubin MA. Urol Oncol. 2014 Nov 20.
Rubin MA. Urol Oncol. 2014 Nov 20.
Prioritizing targets for precision cancer medicine.
Andre F, et al. Ann Oncol. 2014 Dec;25(12):2295-303
Andre F, et al. Ann Oncol. 2014 Dec;25(12):2295-303
Toward precision medicine with next-generation EGFR inhibitors in non-small-cell lung cancer.
Yap TA, Popat S. Pharmgenomics Pers Med. 2014 Sep 19;7:285-95.
Yap TA, Popat S. Pharmgenomics Pers Med. 2014 Sep 19;7:285-95.
Genomically driven precision medicine to improve outcomes in anaplastic thyroid cancer.
Pinto N, et al. J Oncol. 2014;936285
Pinto N, et al. J Oncol. 2014;936285
Translating genomics for precision cancer medicine.
Roychowdhury S, Chinnaiyan AM. Annu Rev Genomics Hum Genet. 2014;15:395-415
Roychowdhury S, Chinnaiyan AM. Annu Rev Genomics Hum Genet. 2014;15:395-415
Cancer Precision Medicine: Where Are We? - September 18, 2014
NIH announces the launch of 3 integrated precision medicine trials; ALCHEMIST is for patients with certain types of early-stage lung cancer, August 2014
National Cancer Institute's Precision Medicine Initiatives for the New National Clinical Trials Network.Jeffrey Abrams et al. ASCO Annual Meeting 2014
Personalized medicine: Special treatment.
Michael Eisenstein. Nature, September 11, 2014
Michael Eisenstein. Nature, September 11, 2014
Why the controversy? Start sequencing tumor genes at diagnosis. Tumor sequencing at the time of diagnosis can give significant insight for successful cancer treatment, by Shelly Gunn, Genetic Engineering & Biotechnology News, Sep 10
National Cancer Institute information: Precision medicine and targeted therapy
Genomics and precision oncology: What's a targeted therapy for cancer? An updated list of approved drugs from the National Cancer Institute (2014)
Therapy: This time it's personal
Gravitz L Nature 509, S52-S54 2014 May 29
Gravitz L Nature 509, S52-S54 2014 May 29
Multi-marker solid tumor panels using next-generation sequencing to direct molecularly targeted therapies
Michael Marrone, et al. PLoS Currents Evidence on Genomic Tests 2014 May 27
Michael Marrone, et al. PLoS Currents Evidence on Genomic Tests 2014 May 27
Impact of cancer genomics on precision medicine for the treatment of cancer, from the National Cancer Institute
Cancer genomics and precision medicine in the 21st century [PDF 2.20 MB], power point presentation from the National Human Genome Research Institute
Personalized Medicine: Opportunities & Challenges - July 2, 2014
The Case for Personalized Medicine - 4th Edition,Personalized Medicine Coalition 2014
Food and Drug Administration Report: Paving the way for personalized medicine [PDF 854.45 KB] (2013)
CDC paper: Population sciences, translational research, and the opportunities and challenges for genomics to reduce the burden of cancer in the 21st century.
Policy and health profession must adapt to personalised medicine, PHG Foundation, June 26, 2014
Reading between the lines; understanding drug response in the post genomic era.
Alifrangis CC1, McDermott U. Mol Oncol. 2014 Jun 10. pii: S1574-7891
Alifrangis CC1, McDermott U. Mol Oncol. 2014 Jun 10. pii: S1574-7891
How does genome sequencing impact surgery?
Marlies S. Reimers et al. Nature Reviews Clinical Oncology 2014 Jun 24
Marlies S. Reimers et al. Nature Reviews Clinical Oncology 2014 Jun 24
Lung-MAP launches: first precision medicine trial from National Clinical Trials Network, by the ASCO Post, Jun 25
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