Chagas Disease
Chagas Disease: Genomic Insights into a Neglected Parasitic Infection - August 4, 2015
CDC and Related Info
- Parasites - American Trypanosomiasis (also known as Chagas Disease)
- The Chagas disease domestic transmission cycle in Guatemala: parasite-vector switches and lack of mitochondrial co-diversification between Triatoma dimidiata and Trypanosoma cruzi subpopulations suggest non-vectorial parasite dispersal across the Motagua valley.
Pennington PM et al.Acta Trop. 2015 Jul 24.
- Genetically modifying the insect gut microbiota to control Chagas disease vectors through systemic RNAi.
Taracena Mabel L et al.PLoS Negl Trop Dis 2015 Feb (2) e0003358
- Genes reported in relation to chagas, including genomewide association studies via theHuGE Navigator
The Chagas disease domestic transmission cycle in Guatemala: parasite-vector switches and lack of mitochondrial co-diversification between Triatoma dimidiata and Trypanosoma cruzi subpopulations suggest non-vectorial parasite dispersal across the Motagua valley.![External Web Site Icon External Web Site Icon](https://lh3.googleusercontent.com/blogger_img_proxy/AEn0k_tDi6j3k1p9CW3fwK58dJOPh4DhoUIQdEpD6QLKRpbGfeyOoCdYuNJ4Q3hIkmLykwG84cPR6CyxqinRxLL1zVRDPslVF8hxbk6iIx_2XaNoKxQ_Hl9wC8zI=s0-d)
Pennington PM et al. Acta Trop. 2015 Jul 24.
Pennington PM et al. Acta Trop. 2015 Jul 24.
Machine learning models and pathway genome data base for Trypanosoma cruzi drug discovery.![External Web Site Icon External Web Site Icon](https://lh3.googleusercontent.com/blogger_img_proxy/AEn0k_tDi6j3k1p9CW3fwK58dJOPh4DhoUIQdEpD6QLKRpbGfeyOoCdYuNJ4Q3hIkmLykwG84cPR6CyxqinRxLL1zVRDPslVF8hxbk6iIx_2XaNoKxQ_Hl9wC8zI=s0-d)
Ekins S et al. PLoS Negl Trop Dis 2015 Jun (6) e0003878
Ekins S et al. PLoS Negl Trop Dis 2015 Jun (6) e0003878
Retrospective distribution of Trypanosoma cruzi I genotypes in Colombia.![External Web Site Icon External Web Site Icon](https://lh3.googleusercontent.com/blogger_img_proxy/AEn0k_tDi6j3k1p9CW3fwK58dJOPh4DhoUIQdEpD6QLKRpbGfeyOoCdYuNJ4Q3hIkmLykwG84cPR6CyxqinRxLL1zVRDPslVF8hxbk6iIx_2XaNoKxQ_Hl9wC8zI=s0-d)
León CM et al. Mem. Inst. Oswaldo Cruz 2015 May (3) 387-93
León CM et al. Mem. Inst. Oswaldo Cruz 2015 May (3) 387-93
Deep sequencing of the Trypanosoma cruzi GP63 surface proteases reveals diversity and diversifying selection among chronic and congenital Chagas disease patients.![External Web Site Icon External Web Site Icon](https://lh3.googleusercontent.com/blogger_img_proxy/AEn0k_tDi6j3k1p9CW3fwK58dJOPh4DhoUIQdEpD6QLKRpbGfeyOoCdYuNJ4Q3hIkmLykwG84cPR6CyxqinRxLL1zVRDPslVF8hxbk6iIx_2XaNoKxQ_Hl9wC8zI=s0-d)
Llewellyn MS et al. PLoS Negl Trop Dis 2015 Apr (4) e0003458
Llewellyn MS et al. PLoS Negl Trop Dis 2015 Apr (4) e0003458
Gene-deleted live-attenuated Trypanosoma cruzi parasites as vaccines to protect against Chagas disease.![External Web Site Icon External Web Site Icon](https://lh3.googleusercontent.com/blogger_img_proxy/AEn0k_tDi6j3k1p9CW3fwK58dJOPh4DhoUIQdEpD6QLKRpbGfeyOoCdYuNJ4Q3hIkmLykwG84cPR6CyxqinRxLL1zVRDPslVF8hxbk6iIx_2XaNoKxQ_Hl9wC8zI=s0-d)
Sánchez-Valdéz FJ et al. Expert Rev Vaccines 2015 May (5) 681-97
Sánchez-Valdéz FJ et al. Expert Rev Vaccines 2015 May (5) 681-97
Molecular genotyping of Trypanosoma cruzi for lineage assignment and population genetics.![External Web Site Icon External Web Site Icon](https://lh3.googleusercontent.com/blogger_img_proxy/AEn0k_tDi6j3k1p9CW3fwK58dJOPh4DhoUIQdEpD6QLKRpbGfeyOoCdYuNJ4Q3hIkmLykwG84cPR6CyxqinRxLL1zVRDPslVF8hxbk6iIx_2XaNoKxQ_Hl9wC8zI=s0-d)
Messenger LA et al. Methods Mol. Biol. 2015 297-337
Messenger LA et al. Methods Mol. Biol. 2015 297-337
CDC information: Chagas disease is considered a neglected parasitic infection targeted for public health action
CDC paper: Genetically modifying the insect gut microbiota to control Chagas disease vectors through systemic RNAi.![External Web Site Icon External Web Site Icon](https://lh3.googleusercontent.com/blogger_img_proxy/AEn0k_tDi6j3k1p9CW3fwK58dJOPh4DhoUIQdEpD6QLKRpbGfeyOoCdYuNJ4Q3hIkmLykwG84cPR6CyxqinRxLL1zVRDPslVF8hxbk6iIx_2XaNoKxQ_Hl9wC8zI=s0-d)
Taracena Mabel L et al. PLoS Negl Trop Dis 2015 Feb (2) e0003358
Taracena Mabel L et al. PLoS Negl Trop Dis 2015 Feb (2) e0003358
Molecular genotyping of Trypanosoma cruzi for lineage assignment and population genetics.![External Web Site Icon External Web Site Icon](https://lh3.googleusercontent.com/blogger_img_proxy/AEn0k_tDi6j3k1p9CW3fwK58dJOPh4DhoUIQdEpD6QLKRpbGfeyOoCdYuNJ4Q3hIkmLykwG84cPR6CyxqinRxLL1zVRDPslVF8hxbk6iIx_2XaNoKxQ_Hl9wC8zI=s0-d)
Messenger Louisa A et al. Methods Mol. Biol. 2015 297-337
Messenger Louisa A et al. Methods Mol. Biol. 2015 297-337
Host genetics and parasitic infections.![External Web Site Icon External Web Site Icon](https://lh3.googleusercontent.com/blogger_img_proxy/AEn0k_tDi6j3k1p9CW3fwK58dJOPh4DhoUIQdEpD6QLKRpbGfeyOoCdYuNJ4Q3hIkmLykwG84cPR6CyxqinRxLL1zVRDPslVF8hxbk6iIx_2XaNoKxQ_Hl9wC8zI=s0-d)
Mangano V D et al. Clin. Microbiol. Infect. 2014 Dec (12) 1265-75
Mangano V D et al. Clin. Microbiol. Infect. 2014 Dec (12) 1265-75
Sequence variation in CYP51A from the Y strain of Trypanosoma cruzi alters its sensitivity to inhibition.![External Web Site Icon External Web Site Icon](https://lh3.googleusercontent.com/blogger_img_proxy/AEn0k_tDi6j3k1p9CW3fwK58dJOPh4DhoUIQdEpD6QLKRpbGfeyOoCdYuNJ4Q3hIkmLykwG84cPR6CyxqinRxLL1zVRDPslVF8hxbk6iIx_2XaNoKxQ_Hl9wC8zI=s0-d)
Cherkesova Tatiana S et al. FEBS Lett. 2014 Nov 3. (21) 3878-85
Cherkesova Tatiana S et al. FEBS Lett. 2014 Nov 3. (21) 3878-85
Chagas disease cardiomyopathy: immunopathology and genetics.![External Web Site Icon External Web Site Icon](https://lh3.googleusercontent.com/blogger_img_proxy/AEn0k_tDi6j3k1p9CW3fwK58dJOPh4DhoUIQdEpD6QLKRpbGfeyOoCdYuNJ4Q3hIkmLykwG84cPR6CyxqinRxLL1zVRDPslVF8hxbk6iIx_2XaNoKxQ_Hl9wC8zI=s0-d)
Cunha-Neto Edecio et al. Mediators Inflamm. 2014 683230
Cunha-Neto Edecio et al. Mediators Inflamm. 2014 683230
Genetic variability and geographical diversity of the main Chagas' disease vector Panstrongylus megistus (Hemiptera: Triatominae) in Brazil based on ribosomal DNA intergenic sequences.![External Web Site Icon External Web Site Icon](https://lh3.googleusercontent.com/blogger_img_proxy/AEn0k_tDi6j3k1p9CW3fwK58dJOPh4DhoUIQdEpD6QLKRpbGfeyOoCdYuNJ4Q3hIkmLykwG84cPR6CyxqinRxLL1zVRDPslVF8hxbk6iIx_2XaNoKxQ_Hl9wC8zI=s0-d)
Cavassin Francelisse Bridi et al. J. Med. Entomol. 2014 May (3) 616-28
Cavassin Francelisse Bridi et al. J. Med. Entomol. 2014 May (3) 616-28
Gene expression changes induced by Trypanosoma cruzi shed microvesicles in mammalian host cells: relevance of tRNA-derived halves.![External Web Site Icon External Web Site Icon](https://lh3.googleusercontent.com/blogger_img_proxy/AEn0k_tDi6j3k1p9CW3fwK58dJOPh4DhoUIQdEpD6QLKRpbGfeyOoCdYuNJ4Q3hIkmLykwG84cPR6CyxqinRxLL1zVRDPslVF8hxbk6iIx_2XaNoKxQ_Hl9wC8zI=s0-d)
Garcia-Silva Maria R et al. Biomed Res Int 2014 305239
Garcia-Silva Maria R et al. Biomed Res Int 2014 305239
Find out what genes have been reported in relation to Chagas disease occurrence and outcomes?Search the HuGE Navigator
Prevalence of Chagas disease in Latin-American igmrants living in Europe: A systematic review and meta-analysis.![External Web Site Icon External Web Site Icon](https://lh3.googleusercontent.com/blogger_img_proxy/AEn0k_tDi6j3k1p9CW3fwK58dJOPh4DhoUIQdEpD6QLKRpbGfeyOoCdYuNJ4Q3hIkmLykwG84cPR6CyxqinRxLL1zVRDPslVF8hxbk6iIx_2XaNoKxQ_Hl9wC8zI=s0-d)
Requena-Méndez Ana et al. PLoS Negl Trop Dis 2015 Feb (2) e0003540
Requena-Méndez Ana et al. PLoS Negl Trop Dis 2015 Feb (2) e0003540
Trypanosomatids topoisomerase re-visited. New structural findings and role in drug discovery.![External Web Site Icon External Web Site Icon](https://lh3.googleusercontent.com/blogger_img_proxy/AEn0k_tDi6j3k1p9CW3fwK58dJOPh4DhoUIQdEpD6QLKRpbGfeyOoCdYuNJ4Q3hIkmLykwG84cPR6CyxqinRxLL1zVRDPslVF8hxbk6iIx_2XaNoKxQ_Hl9wC8zI=s0-d)
Balaña-Fouce Rafael et al. Int J Parasitol Drugs Drug Resist 2014 Dec (3) 326-37
Balaña-Fouce Rafael et al. Int J Parasitol Drugs Drug Resist 2014 Dec (3) 326-37
Trypanosoma cruzi, the causal agent of Chagas disease: Boundaries between wild and domestic cycles in Venezuela.![External Web Site Icon External Web Site Icon](https://lh3.googleusercontent.com/blogger_img_proxy/AEn0k_tDi6j3k1p9CW3fwK58dJOPh4DhoUIQdEpD6QLKRpbGfeyOoCdYuNJ4Q3hIkmLykwG84cPR6CyxqinRxLL1zVRDPslVF8hxbk6iIx_2XaNoKxQ_Hl9wC8zI=s0-d)
Herrera Leidi et al. Front Public Health 2014 259
Herrera Leidi et al. Front Public Health 2014 259
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