Hepatitis
Hepatitis: Public Health and Genomic Insights - July 27, 2015
CDC and Related Info
- World Hepatitis Day — July 28, 2015MMWR, July 24, 2015
- Apolipoprotein E and protection against hepatitis E virus infection in American, non-Hispanic blacks.
Zhang L et al.Hepatology 2015 Jun 11.
- Hepatitis Awareness Month
- Using advanced molecular techniques for rapid identification of hepatitis C outbreaks
- World Hepatitis Day
- CDC information on viral hepatitis
- Take this 5 minute hepatitis risk assessment
- Recommendations for the identification of chronic hepatitis C virus infection among persons born during 1945–1965
- Genes reported in relation to hepatitis, including genomewide association studies via theHuGE Navigator
Predictive factors associated with hepatitis C antiviral therapy response.![External Web Site Icon External Web Site Icon](https://lh3.googleusercontent.com/blogger_img_proxy/AEn0k_vtDSGMI-yEezW7P4xVGYYkjlbjLLdcDfSqDf3al8Q8qcsxBiogiQj8SslVDfzwez2cIM6UbpbkGJDzq1MNEd92BUmj0NVtjfabKOQqWNS3ENvRw7ClRekD=s0-d)
Cavalcante LN et al.World J Hepatol 2015 Jun 28. (12) 1617-31
Cavalcante LN et al.World J Hepatol 2015 Jun 28. (12) 1617-31
Clinical relevance of hepatitis B virus variants.![External Web Site Icon External Web Site Icon](https://lh3.googleusercontent.com/blogger_img_proxy/AEn0k_vtDSGMI-yEezW7P4xVGYYkjlbjLLdcDfSqDf3al8Q8qcsxBiogiQj8SslVDfzwez2cIM6UbpbkGJDzq1MNEd92BUmj0NVtjfabKOQqWNS3ENvRw7ClRekD=s0-d)
Gao S et al. World J Hepatol 2015 May 18. (8) 1086-96
Gao S et al. World J Hepatol 2015 May 18. (8) 1086-96
Comparative clinical effectiveness and value of novel interferon-free combination therapy for hepatitis C genotype 1: Summary of California Technology Assessment Forum Report![External Web Site Icon External Web Site Icon](https://lh3.googleusercontent.com/blogger_img_proxy/AEn0k_vtDSGMI-yEezW7P4xVGYYkjlbjLLdcDfSqDf3al8Q8qcsxBiogiQj8SslVDfzwez2cIM6UbpbkGJDzq1MNEd92BUmj0NVtjfabKOQqWNS3ENvRw7ClRekD=s0-d)
Tice JA et al. JAMA Internal Medicine, July 13, 2015
Tice JA et al. JAMA Internal Medicine, July 13, 2015
Apolipoprotein E and protection against hepatitis E virus infection in American, non-Hispanic blacks.![External Web Site Icon External Web Site Icon](https://lh3.googleusercontent.com/blogger_img_proxy/AEn0k_vtDSGMI-yEezW7P4xVGYYkjlbjLLdcDfSqDf3al8Q8qcsxBiogiQj8SslVDfzwez2cIM6UbpbkGJDzq1MNEd92BUmj0NVtjfabKOQqWNS3ENvRw7ClRekD=s0-d)
Zhang L et al. Hepatology 2015 Jun 11.
Zhang L et al. Hepatology 2015 Jun 11.
CDC information: Hepatitis Awareness Month
Interleukin 28B polymorphisms as predictors of sustained virological response in chronic hepatitis C: systematic review and meta-analysis.![External Web Site Icon External Web Site Icon](https://lh3.googleusercontent.com/blogger_img_proxy/AEn0k_vtDSGMI-yEezW7P4xVGYYkjlbjLLdcDfSqDf3al8Q8qcsxBiogiQj8SslVDfzwez2cIM6UbpbkGJDzq1MNEd92BUmj0NVtjfabKOQqWNS3ENvRw7ClRekD=s0-d)
Cariani E et al. Pharmacogenomics J. 2015 Apr 28.
Cariani E et al. Pharmacogenomics J. 2015 Apr 28.
Intracellular accumulation of boceprevir according to plasma concentrations and pharmacogenetics.![External Web Site Icon External Web Site Icon](https://lh3.googleusercontent.com/blogger_img_proxy/AEn0k_vtDSGMI-yEezW7P4xVGYYkjlbjLLdcDfSqDf3al8Q8qcsxBiogiQj8SslVDfzwez2cIM6UbpbkGJDzq1MNEd92BUmj0NVtjfabKOQqWNS3ENvRw7ClRekD=s0-d)
Cusato J et al. Int. J. Antimicrob. Agents 2015 Mar 14.
Cusato J et al. Int. J. Antimicrob. Agents 2015 Mar 14.
Serum interferon-related microRNAs as biomarkers to predict the response to interferon therapy in chronic hepatitis C genotype 4.![External Web Site Icon External Web Site Icon](https://lh3.googleusercontent.com/blogger_img_proxy/AEn0k_vtDSGMI-yEezW7P4xVGYYkjlbjLLdcDfSqDf3al8Q8qcsxBiogiQj8SslVDfzwez2cIM6UbpbkGJDzq1MNEd92BUmj0NVtjfabKOQqWNS3ENvRw7ClRekD=s0-d)
Motawi TK et al. PLoS ONE 2015 (3) e0120794
Motawi TK et al. PLoS ONE 2015 (3) e0120794
PEG-interferon-α ribavirin-induced HCV viral clearance: a pharmacogenetic multicenter Spanish study.![External Web Site Icon External Web Site Icon](https://lh3.googleusercontent.com/blogger_img_proxy/AEn0k_vtDSGMI-yEezW7P4xVGYYkjlbjLLdcDfSqDf3al8Q8qcsxBiogiQj8SslVDfzwez2cIM6UbpbkGJDzq1MNEd92BUmj0NVtjfabKOQqWNS3ENvRw7ClRekD=s0-d)
Milara J et al. Farm Hosp 2015 Jan-Feb (1) 29-43
Milara J et al. Farm Hosp 2015 Jan-Feb (1) 29-43
The role of pharmacogenetics in the treatment of chronic hepatitis C infection.![External Web Site Icon External Web Site Icon](https://lh3.googleusercontent.com/blogger_img_proxy/AEn0k_vtDSGMI-yEezW7P4xVGYYkjlbjLLdcDfSqDf3al8Q8qcsxBiogiQj8SslVDfzwez2cIM6UbpbkGJDzq1MNEd92BUmj0NVtjfabKOQqWNS3ENvRw7ClRekD=s0-d)
Kawaguchi-Suzuki M et al. Pharmacotherapy 2014 Feb (2) 185-201
Kawaguchi-Suzuki M et al. Pharmacotherapy 2014 Feb (2) 185-201
Clinical Pharmacogenetics Implementation Consortium (CPIC) guidelines for IFNL3 (IL28B) genotype and PEG interferon-α-based regimens.![External Web Site Icon External Web Site Icon](https://lh3.googleusercontent.com/blogger_img_proxy/AEn0k_vtDSGMI-yEezW7P4xVGYYkjlbjLLdcDfSqDf3al8Q8qcsxBiogiQj8SslVDfzwez2cIM6UbpbkGJDzq1MNEd92BUmj0NVtjfabKOQqWNS3ENvRw7ClRekD=s0-d)
Muir AJ et al. Clin. Pharmacol. Ther. 2014 Feb (2) 141-6
Muir AJ et al. Clin. Pharmacol. Ther. 2014 Feb (2) 141-6
Hepatitis: Recent Genomic Insights - February 9, 2015
CDC information: Using advanced molecular techniques for rapid identification of hepatitis C outbreaks
CDC paper: Outbreak of hepatitis A in the USA associated with frozen pomegranate arils imported from Turkey: an epidemiological case study![External Web Site Icon External Web Site Icon](https://lh3.googleusercontent.com/blogger_img_proxy/AEn0k_vtDSGMI-yEezW7P4xVGYYkjlbjLLdcDfSqDf3al8Q8qcsxBiogiQj8SslVDfzwez2cIM6UbpbkGJDzq1MNEd92BUmj0NVtjfabKOQqWNS3ENvRw7ClRekD=s0-d)
Collier MG, et al. Lancet Infect Dis. 2014 Sep 3. pii: S1473-3099(14)70883-7.
Collier MG, et al. Lancet Infect Dis. 2014 Sep 3. pii: S1473-3099(14)70883-7.
CDC paper: Next-generation sequencing reveals large connected networks of intra-host HCV variants![External Web Site Icon External Web Site Icon](https://lh3.googleusercontent.com/blogger_img_proxy/AEn0k_vtDSGMI-yEezW7P4xVGYYkjlbjLLdcDfSqDf3al8Q8qcsxBiogiQj8SslVDfzwez2cIM6UbpbkGJDzq1MNEd92BUmj0NVtjfabKOQqWNS3ENvRw7ClRekD=s0-d)
Campo DS, et al. BMC Genomics. 2014 Jul 14;15 Suppl 5:S4.
Campo DS, et al. BMC Genomics. 2014 Jul 14;15 Suppl 5:S4.
Ultradeep pyrosequencing of NS3 to predict response to triple therapy with protease inhibitors in previously treated chronic hepatitis C patients.![External Web Site Icon External Web Site Icon](https://lh3.googleusercontent.com/blogger_img_proxy/AEn0k_vtDSGMI-yEezW7P4xVGYYkjlbjLLdcDfSqDf3al8Q8qcsxBiogiQj8SslVDfzwez2cIM6UbpbkGJDzq1MNEd92BUmj0NVtjfabKOQqWNS3ENvRw7ClRekD=s0-d)
Larrat S et al. J Clin Microbiol. 2015 Feb;53(2):389-97.
Larrat S et al. J Clin Microbiol. 2015 Feb;53(2):389-97.
Differentiation of acute from chronic hepatitis C virus infection by NS5B deep sequencing: A population-level tool for incidence estimation.![External Web Site Icon External Web Site Icon](https://lh3.googleusercontent.com/blogger_img_proxy/AEn0k_vtDSGMI-yEezW7P4xVGYYkjlbjLLdcDfSqDf3al8Q8qcsxBiogiQj8SslVDfzwez2cIM6UbpbkGJDzq1MNEd92BUmj0NVtjfabKOQqWNS3ENvRw7ClRekD=s0-d)
Montoya V et al. Hepatology. 2015 Feb 2.
Montoya V et al. Hepatology. 2015 Feb 2.
Whole genome characterization of hepatitis B virus quasispecies with massively parallel pyrosequencing.![External Web Site Icon External Web Site Icon](https://lh3.googleusercontent.com/blogger_img_proxy/AEn0k_vtDSGMI-yEezW7P4xVGYYkjlbjLLdcDfSqDf3al8Q8qcsxBiogiQj8SslVDfzwez2cIM6UbpbkGJDzq1MNEd92BUmj0NVtjfabKOQqWNS3ENvRw7ClRekD=s0-d)
Li F, et al. Clin Microbiol Infect. 2014 Oct 29
Li F, et al. Clin Microbiol Infect. 2014 Oct 29
Age-related immune clearance of hepatitis B virus infection requires the establishment of gut microbiota.![External Web Site Icon External Web Site Icon](https://lh3.googleusercontent.com/blogger_img_proxy/AEn0k_vtDSGMI-yEezW7P4xVGYYkjlbjLLdcDfSqDf3al8Q8qcsxBiogiQj8SslVDfzwez2cIM6UbpbkGJDzq1MNEd92BUmj0NVtjfabKOQqWNS3ENvRw7ClRekD=s0-d)
Chou HH, et al. Proc Natl Acad Sci U S A. 2015 Feb 2
Chou HH, et al. Proc Natl Acad Sci U S A. 2015 Feb 2
Whole-genome mutational landscape of liver cancers displaying biliary phenotype reveals hepatitis impact and molecular diversity.![External Web Site Icon External Web Site Icon](https://lh3.googleusercontent.com/blogger_img_proxy/AEn0k_vtDSGMI-yEezW7P4xVGYYkjlbjLLdcDfSqDf3al8Q8qcsxBiogiQj8SslVDfzwez2cIM6UbpbkGJDzq1MNEd92BUmj0NVtjfabKOQqWNS3ENvRw7ClRekD=s0-d)
Fujimoto A, et al. Nat Commun. 2015 Jan 30;6:6120
Fujimoto A, et al. Nat Commun. 2015 Jan 30;6:6120
A deep-sequencing method detects drug-resistant mutations in the hepatitis B virus in Indonesians.![External Web Site Icon External Web Site Icon](https://lh3.googleusercontent.com/blogger_img_proxy/AEn0k_vtDSGMI-yEezW7P4xVGYYkjlbjLLdcDfSqDf3al8Q8qcsxBiogiQj8SslVDfzwez2cIM6UbpbkGJDzq1MNEd92BUmj0NVtjfabKOQqWNS3ENvRw7ClRekD=s0-d)
Widasari DI, et al. Intervirology. 2014;57(6):384-92.
Widasari DI, et al. Intervirology. 2014;57(6):384-92.
Cost-effectiveness of IL28Β genotype-guided protease inhibitor triple therapy versus standard of care treatment in patients with hepatitis C genotypes 2 or 3 infection.![External Web Site Icon External Web Site Icon](https://lh3.googleusercontent.com/blogger_img_proxy/AEn0k_vtDSGMI-yEezW7P4xVGYYkjlbjLLdcDfSqDf3al8Q8qcsxBiogiQj8SslVDfzwez2cIM6UbpbkGJDzq1MNEd92BUmj0NVtjfabKOQqWNS3ENvRw7ClRekD=s0-d)
Bock JA, et al. Public Health Genomics. 2014;17(5-6):306-19.
Bock JA, et al. Public Health Genomics. 2014;17(5-6):306-19.
A genomic and clinical prognostic index for hepatitis C-related early-stage cirrhosis that predicts clinical deterioration.![External Web Site Icon External Web Site Icon](https://lh3.googleusercontent.com/blogger_img_proxy/AEn0k_vtDSGMI-yEezW7P4xVGYYkjlbjLLdcDfSqDf3al8Q8qcsxBiogiQj8SslVDfzwez2cIM6UbpbkGJDzq1MNEd92BUmj0NVtjfabKOQqWNS3ENvRw7ClRekD=s0-d)
King LY, et al. Gut. 2014 Aug 20.
King LY, et al. Gut. 2014 Aug 20.
Hepatitis C virus in the new era: perspectives in epidemiology, prevention, diagnostics and predictors of response to therapy.![External Web Site Icon External Web Site Icon](https://lh3.googleusercontent.com/blogger_img_proxy/AEn0k_vtDSGMI-yEezW7P4xVGYYkjlbjLLdcDfSqDf3al8Q8qcsxBiogiQj8SslVDfzwez2cIM6UbpbkGJDzq1MNEd92BUmj0NVtjfabKOQqWNS3ENvRw7ClRekD=s0-d)
Ansaldi F, et al. World J Gastroenterol. 2014 Aug 7;20(29):9633-52.
Ansaldi F, et al. World J Gastroenterol. 2014 Aug 7;20(29):9633-52.
Deep sequencing: becoming a critical tool in clinical virology.![External Web Site Icon External Web Site Icon](https://lh3.googleusercontent.com/blogger_img_proxy/AEn0k_vtDSGMI-yEezW7P4xVGYYkjlbjLLdcDfSqDf3al8Q8qcsxBiogiQj8SslVDfzwez2cIM6UbpbkGJDzq1MNEd92BUmj0NVtjfabKOQqWNS3ENvRw7ClRekD=s0-d)
Quiñones-Mateu ME, et al. J Clin Virol. 2014 Sep;61(1):9-19
Quiñones-Mateu ME, et al. J Clin Virol. 2014 Sep;61(1):9-19
Hepatitis: Genomics & Public Health - July 31, 2014
CDC information: World Hepatitis Day
CDC information on hepatitis
Hepatitis B and Hepatitis C can become chronic, life-long infections which can lead to liver cancer. Millions of Americans are living with chronic viral hepatitis, and many do not know they are infected
CDC information on hepatitis
Hepatitis B and Hepatitis C can become chronic, life-long infections which can lead to liver cancer. Millions of Americans are living with chronic viral hepatitis, and many do not know they are infected
Take this 5 minute hepatitis risk assessment developed by the CDC and get a personalized report
CDC paper: Viral hepatitis C gets personal--the value of human genomics to public health.![External Web Site Icon External Web Site Icon](https://lh3.googleusercontent.com/blogger_img_proxy/AEn0k_vtDSGMI-yEezW7P4xVGYYkjlbjLLdcDfSqDf3al8Q8qcsxBiogiQj8SslVDfzwez2cIM6UbpbkGJDzq1MNEd92BUmj0NVtjfabKOQqWNS3ENvRw7ClRekD=s0-d)
Zhang L, Gwinn M, Hu DJ. Public Health Genomics. 2013;16(4):192-7.
Zhang L, Gwinn M, Hu DJ. Public Health Genomics. 2013;16(4):192-7.
Did you know? > 1300 genes have been reported in relation to risk and outcomes of hepatitis, including 56 genomewide association studies and 70 meta analyses? To find out more, visit the HuGE Navigator![External Web Site Icon External Web Site Icon](https://lh3.googleusercontent.com/blogger_img_proxy/AEn0k_vtDSGMI-yEezW7P4xVGYYkjlbjLLdcDfSqDf3al8Q8qcsxBiogiQj8SslVDfzwez2cIM6UbpbkGJDzq1MNEd92BUmj0NVtjfabKOQqWNS3ENvRw7ClRekD=s0-d)
Integrative functional genomics of hepatitis C virus infection identifies host dependencies in complete viral replication cycle![External Web Site Icon External Web Site Icon](https://lh3.googleusercontent.com/blogger_img_proxy/AEn0k_vtDSGMI-yEezW7P4xVGYYkjlbjLLdcDfSqDf3al8Q8qcsxBiogiQj8SslVDfzwez2cIM6UbpbkGJDzq1MNEd92BUmj0NVtjfabKOQqWNS3ENvRw7ClRekD=s0-d)
Qisheng Li et al. PloS Pathogens, May, 2014
Qisheng Li et al. PloS Pathogens, May, 2014
Meta-analysis: implications of interleukin-28B polymorphisms in spontaneous and treatment-related clearance for patients with hepatitis C![External Web Site Icon External Web Site Icon](https://lh3.googleusercontent.com/blogger_img_proxy/AEn0k_vtDSGMI-yEezW7P4xVGYYkjlbjLLdcDfSqDf3al8Q8qcsxBiogiQj8SslVDfzwez2cIM6UbpbkGJDzq1MNEd92BUmj0NVtjfabKOQqWNS3ENvRw7ClRekD=s0-d)
María A Jiménez-Sousa et al. BMC Medicine 2013
María A Jiménez-Sousa et al. BMC Medicine 2013
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