Cancer Genetics Risk Assessment and Counseling (PDQ®)–Health Professional Version

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Changes to This Summary (05/11/2017)

The PDQ cancer information summaries are reviewed regularly and updated as new information becomes available. This section describes the latest changes made to this summary as of the date above.

The Option of Genetic Testing

Added Moran et al. and Frey et al. as references 27 and 29, respectively.

Added text to state that in some cases, the identification of pathogenic variants from panel testing resulted in additional recommendations for screening and risk reduction beyond what would have been indicated based on family history alone (cited Ricker et al., Hermel et al., and Eliade et al. as references 32, 33, and 34, respectively).

Revised text to state that a challenge of interpreting multigene test results includes higher rates of variants of uncertain significance in some minority populations (cited Eggington et al. as reference 41).

This summary is written and maintained by the PDQ Cancer Genetics Editorial Board, which is editorially independent of NCI. The summary reflects an independent review of the literature and does not represent a policy statement of NCI or NIH. More information about summary policies and the role of the PDQ Editorial Boards in maintaining the PDQ summaries can be found on the About This PDQ Summary and PDQ® - NCI's Comprehensive Cancer Database pages.

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