Liquid biopsy [NEW TOPIC PAGE]

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Caption: DNA (blue) loops around nucleosomes (gray) and is bound by transcription factors (red), proteins that switch genes on and off and act in a tissue-specific manner. When cells die, enzymes (scissors) chop up areas between the nucleosomes and transcription factors, releasing DNA fragments in unique patterns. By gathering the released DNA fragments in blood, researchers can tell which types of cells produced them.
Credit: Shendure Lab/University of Washington

Last Posted: Dec 06, 2018

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• A Prospective Study of Circulating Tumor DNA to Guide Matched Targeted Therapy in Lung Cancers.
  Sabari Joshua K et al. Journal of the National Cancer Institute 2018 Nov
• Scientists develop 10-minute universal cancer test
  The Guardian, December 4, 2018
• A Case-control Study Supporting the Use of Liquid Biopsy in the Targeted Therapy for Lung Cancer
  Dai Li-Jun et al. Asian Pacific journal of cancer prevention : APJCP 2018 Jul 19(7) 1761-1766
• Circulating tumour DNA sequence analysis as an alternative to multiple myeloma bone marrow aspirates.
  Kis Olena et al. Nature communications 2017 815086
• Liquid Biopsy in Endometrial Cancer: New Opportunities for Personalized Oncology.
  Muinelo-Romay Laura et al. International journal of molecular sciences 2018 Aug 19(8)
• A Novel Multiplex droplet digital PCR Assay to Identify and Quantify KRAS Mutations in Clinical Specimens.
  Alcaide Miguel et al. The Journal of molecular diagnostics : JMD 2018 Nov
• Plasma Dynamics of RAS/RAF Mutations in Patients With Metastatic Colorectal Cancer Receiving Chemotherapy and Anti-EGFR Treatment.
  Thomsen Caroline Brenner et al. Clinical colorectal cancer 2018 Oct
• Rechallenge for Patients With RAS and BRAF Wild-Type Metastatic Colorectal Cancer With Acquired Resistance to First-line Cetuximab and Irinotecan: A Phase 2 Single-Arm Clinical Trial.
  Cremolini Chiara et al. JAMA oncology 2018 Nov
• Diagnostic value of combined IQGAP3/BMP4 and IQGAP3/FAM107A expression ratios in urinary cell-free DNA for discriminating bladder cancer from hematuria.
  Xu Yanjie et al. Urologic oncology 2018 Nov
• Prospective study revealed prognostic significance of responses in leptomeningeal metastasis and clinical value of cerebrospinal fluid-based liquid biopsy.
  Xu Yan et al. Lung cancer (Amsterdam, Netherlands) 2018 Nov 125142-149

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