Journal of Translational Medicine | Pain, Critical Care and Anesthesia

Pain, Critical Care and Anesthesia

Section edited by Yasin S. Al Makadma

Pain, Critical Care and Anesthesia section encompasses three major fields that are often tightly inter-related both historically and in everyday practice. A systematic Translational Medical approach may be our best route towards analysing common links and complete some of our limited understanding of common clinical pictures. Our section will also contribute in the understanding of mechanistic aspect of different anaesthetic agents and molecules and attempt to deepen the insight in the role of pharmacogenetics.

For that to happen, this section welcomes a very wide range of original research and review articles in related areas.

Content Type:Research
Dexmedetomidine expands monocytic myeloid-derived suppressor cells and promotes tumour metastasis after lung cancer surgery
Dexmedetomidine (DEX) has been reported to promote tumour metastases. However the underlying mechanisms remain unclear. The purpose of this study was to investigate whether DEX promotes tumour metastasis by in...
Authors:Xiaosan Su, Yaodong Fan, Liu Yang, Jie Huang, Fei Qiao, Yu Fang and Jun Wang
Citation:Journal of Translational Medicine 2018 16:347
Published on: 11 December 2018
- ViewFull Text
- ViewPDF
Content Type:Research
Early goal-directed and lactate-guided therapy in adult patients with severe sepsis and septic shock: a meta-analysis of randomized controlled trials
The ProCESS, ARISE, and ProMISe trials have failed to show that early goal-directed therapy (EGDT) reduces mortality in patients with severe sepsis and septic shock. Although lactate-guided therapy (LGT) has b...
Authors:Xian-Fei Ding, Zi-Yue Yang, Zhen-Tao Xu, Li-Feng Li, Bo Yuan, Li-Na Guo, Le-Xin Wang, Xi Zhu and Tong-Wen Sun
Citation:Journal of Translational Medicine 2018 16:331
Published on: 29 November 2018
- ViewFull Text
- ViewPDF
Content Type:Research
Lactobacillus salivarius reverse antibiotic-induced lung defense impairment in a ventilator model
Widespread use of antibiotics in the intensive care unit is a potential cause of the emergence of hospital-acquired pneumonia. This study determined whether Lactobacillus salivarius feeding could reverse antibiot...
Authors:Tzyy-Bin Tsay, Ming-Chieh Yang, Wan-Hsuan Chang, Pei-Hsuan Chen and Lee-Wei Chen
Citation:Journal of Translational Medicine 2018 16:225
Published on: 13 August 2018
- ViewFull Text
- ViewPDF
Content Type:Research
Dexmedetomidine attenuates spinal cord ischemia–reperfusion injury through both anti-inflammation and anti-apoptosis mechanisms in rabbits
Dexmedetomidine (Dex) can improve neuronal viability and protect the spinal cord from ischemia–reperfusion (I/R) injury, but the underlying mechanisms are not fully understood. This study investigated the effe...
Authors:Zhixiang Sun, Tianyun Zhao, Shaojun Lv, Ying Gao, Joe Masters and Hao Weng
Citation:Journal of Translational Medicine 2018 16:209
Published on: 21 July 2018
- ViewFull Text
- ViewPDF
Content Type:Research
Acquired immunological imbalance after surgery with cardiopulmonary bypass due to epigenetic over-activation of PU.1/M-CSF
It has been shown that severe insult to the immune system may trigger prolonged macrophage characteristics associated with excessive release of monocyte colony stimulating factor (M-CSF). However, it is unclea...
Authors:Krzysztof Laudanski, Mateusz Zawadka, Jacek Polosak, Jaymin Modi, Matthew DiMeglio, Jacob Gutsche, Wilson Y. Szeto and Monika Puzianowska-Kuznicka
Citation:Journal of Translational Medicine 2018 16:143
Published on: 25 May 2018
- ViewFull Text
- ViewPDF
Content Type:Research
Dexmedetomidine attenuates lung apoptosis induced by renal ischemia–reperfusion injury through α2AR/PI3K/Akt pathway
Acute lung injury caused by renal ischemia–reperfusion is one of the leading causes of acute kidney injury-related death. Dexmedetomidine, an α2-adrenergic agonist sedative, has been found to have protective effe...
Authors:Juanjuan Li, Qian Chen, Xinhai He, Azeem Alam, Jiaolin Ning, Bin Yi, Kaizhi Lu and Jianteng Gu
Citation:Journal of Translational Medicine 2018 16:78
Published on: 23 March 2018
- ViewFull Text
- ViewPDF
Content Type:Research
R-100 improves pulmonary function and systemic fluid balance in sheep with combined smoke-inhalation injury and Pseudomonas aeruginosa sepsis
Septic shock is a major cause of death in intensive care units around the world . The aim of the study was to investigate whether the novel drug R-100 (a superoxide degradation catalyst and nitric oxide donor)...
Authors:Hiroshi Ito, Erik Malgerud, Sven Asmussen, Ernesto Lopez, Andrew L. Salzman and Perenlei Enkhbaatar
Citation:Journal of Translational Medicine 2017 15:266
Published on: 28 December 2017
- ViewFull Text
- ViewPDF
Content Type:Protocol
Inorganic nitrate as a treatment for acute heart failure: a protocol for a single center, randomized, double-blind, placebo-controlled pilot and feasibility study
Acute heart failure (AHF) is a frequent reason for hospitalization worldwide and effective treatment options are limited. It is known that AHF is a condition characterized by impaired vasorelaxation, together ...
Authors:Roman Falls, Michael Seman, Sabine Braat, Joshua Sortino, Jason D. Allen and Christopher J. Neil
Citation:Journal of Translational Medicine 2017 15:172
Published on: 8 August 2017
- ViewFull Text
- ViewPDF
Content Type:Research
Temperature variability in the day–night cycle is associated with further intracranial pressure during therapeutic hypothermia
To assess whether circadian patterns of temperature correlate with further values of intracranial pressure (ICP) in severe brain injury treated with hypothermia.
Authors:Adriano Barreto Nogueira, Eva Annen, Oliver Boss, Faraneh Farokhzad, Christopher Sikorski and Emanuela Keller
Citation:Journal of Translational Medicine 2017 15:170
Published on: 3 August 2017
- ViewFull Text
- ViewPDF
Content Type:Research
MicroRNA-223 demonstrated experimentally in exosome-like vesicles is associated with decreased risk of persistent pain after lumbar disc herniation
Previous findings have demonstrated that lumbar radicular pain after disc herniation may be associated with up-regulation of inflammatory mediators. In the present study we examined the possible role of extrac...
Authors:Aurora Moen, Daniel Jacobsen, Santosh Phuyal, Anna Legfeldt, Fred Haugen, Cecilie Røe and Johannes Gjerstad
Citation:Journal of Translational Medicine 2017 15:89
Published on: 1 May 2017
- ViewFull Text
- ViewPDF
Content Type:Review
The role of vitamin C in the treatment of pain: new insights
The vitamin C deficiency disease scurvy is characterised by musculoskeletal pain and recent epidemiological evidence has indicated an association between suboptimal vitamin C status and spinal pain. Furthermor...
Authors:Anitra C. Carr and Cate McCall
Citation:Journal of Translational Medicine 2017 15:77
Published on: 14 April 2017
- ViewFull Text
- ViewPDF
Content Type:Research
Inhibitory effects of serum from sepsis patients on epithelial cell migration in vitro: a case control study
Sepsis delays wound re-epithelialization. In this study we explored the effect of human sepsis sera as well as the effects of cytokines, growth factors and exosomes of sepsis sera treated normal fibroblasts (N...
Authors:Henna Jaurila, Vesa Koivukangas, Marjo Koskela, Fiia Gäddnäs, Sirpa Salo, Johanna Korvala, Maija Risteli, Toni Karhu, Karl-Heinz Herzig, Tuula Salo and Tero I. Ala-Kokko
Citation:Journal of Translational Medicine 2017 15:11
Published on: 13 January 2017
- ViewFull Text
- ViewPDF
Content Type:Research
Does therapeutic hypothermia during extracorporeal cardiopulmonary resuscitation preserve cardiac function?
Extracorporeal cardiopulmonary resuscitation (E-CPR) is increasingly used as a rescue method in the management of cardiac arrest and provides the opportunity to rapidly induce therapeutic hypothermia. The surv...
Authors:Harald A. Bergan, Per S. Halvorsen, Helge Skulstad, Erik Fosse and Jan F. Bugge
Citation:Journal of Translational Medicine 2016 14:345
Published on: 20 December 2016
- ViewFull Text
- ViewPDF
Content Type:Research
AQP5-1364A/C polymorphism and the AQP5 expression influence sepsis survival and immune cell migration: a prospective laboratory and patient study
The C-allele of the aquaporin (AQP5) -1364A/C polymorphism is associated with decreased AQP5 expression but increased 30-day survival in patients with severe sepsis. AQP5 expression might affect survival via a...
Authors:Katharina Rump, Matthias Unterberg, Lars Bergmann, Agnes Bankfalvi, Anil Menon, Simon Schäfer, André Scherag, Zainab Bazzi, Winfried Siffert, Jürgen Peters and Michael Adamzik
Citation:Journal of Translational Medicine 2016 14:321
Published on: 21 November 2016
- ViewFull Text
- ViewPDF
Content Type:Research
Changes in ceftriaxone pharmacokinetics/pharmacodynamics during the early phase of sepsis: a prospective, experimental study in the rat
Sepsis is characterized by the loss of the perm-selectivity properties of the glomerular filtration barrier (GFB) with consequent albuminuria. We examined whether the pharmacokinetics–pharmacodynamics (PK/PD) ...
Authors:Valentina Selmi, Beatrice Loriga, Luca Vitali, Martina Carlucci, Alessandro Di Filippo, Giulio Carta, Eleonora Sgambati, Lorenzo Tofani, Angelo Raffaele De Gaudio, Andrea Novelli and Chiara Adembri
Citation:Journal of Translational Medicine 2016 14:316
Published on: 15 November 2016
- ViewFull Text
- ViewPDF
Content Type:Research
Soluble programmed cell death receptor-1 (sPD-1): a potential biomarker with anti-inflammatory properties in human and experimental acute respiratory distress syndrome (ARDS)
Acute respiratory distress syndrome (ARDS) remains a common organ dysfunction in the critically ill patient. Mechanisms for its development have focused on immune mediated causes, aspects of our understanding ...
Authors:Sean F. Monaghan, Chun-Shiang Chung, Yaping Chen, Joanne Lomas-Neira, William G. Fairbrother, Daithi S. Heffernan, William G. Cioffi and Alfred Ayala
Citation:Journal of Translational Medicine 2016 14:312
Published on: 11 November 2016
- ViewFull Text
- ViewPDF
Content Type:Research
Effect of helium pre- or postconditioning on signal transduction kinases in patients undergoing coronary artery bypass graft surgery
The noble gas helium induces pre- and postconditioning in animals and humans. Volatile anesthetics induce cardioprotection in humans undergoing coronary artery bypass graft (CABG) surgery. We hypothesized that...
Authors:Kirsten F. Smit, Daniel Brevoord, Stefan De Hert, Bas A. de Mol, Raphaela P. Kerindongo, Susan van Dieren, Wolfgang S. Schlack, Markus W. Hollmann, Nina C. Weber and Benedikt Preckel
Citation:Journal of Translational Medicine 2016 14:294
Published on: 14 October 2016
- ViewFull Text
- ViewPDF
Content Type:Research
Microcirculatory blood flow during cardiac arrest and cardiopulmonary resuscitation does not correlate with global hemodynamics: an experimental study
Current research highlights the role of microcirculatory disorders in post-cardiac arrest patients. Affected microcirculation shows not only dissociation from systemic hemodynamics but also strong connection t...
Authors:Petra Krupičková, Mikuláš Mlček, Michal Huptych, Zuzana Mormanová, Tomáš Bouček, Tomáš Belza, Stanislav Lacko, Miloš Černý, Petr Neužil, Otomar Kittnar, Aleš Linhart and Jan Bělohlávek
Citation:Journal of Translational Medicine 2016 14:163
Published on: 8 June 2016
- ViewFull Text
- ViewPDF
Content Type:Review
Early life programming of pain: focus on neuroimmune to endocrine communication
Chronic pain constitutes a challenge for the scientific community and a significant economic and social cost for modern societies. Given the failure of current drugs to effectively treat chronic pain, which ar...
Authors:I. Zouikr, M. D. Bartholomeusz and D. M. Hodgson
Citation:Journal of Translational Medicine 2016 14:123
Published on: 6 May 2016
- ViewFull Text
- ViewPDF
Content Type:Research
Hsa-miR-34a mediated repression of corticotrophin releasing hormone receptor 1 regulates pro-opiomelanocortin expression in patients with complex regional pain syndrome
Ketamine provides relief for a subset of patients with complex regional pain syndrome (CRPS). The poor responders had a lower body mass index (BMI) relative to responders. Regulation of proopiomelanocortin (PO...
Authors:Botros B. Shenoda, Guillermo M. Alexander and Seena K. Ajit
Citation:Journal of Translational Medicine 2016 14:64
Published on: 3 March 2016
- ViewFull Text
- ViewPDF
Content Type:Research
Adverse effects of hydroxyethyl starch (HES 130/0.4) on intestinal barrier integrity and metabolic function are abrogated by supplementation with Albumin
Volume resuscitation with hydroxyethyl starch (HES) is controversially discussed and we recently showed that HES perfusion impairs endothelial and epithelial intestinal barrier integrity. Here we investigated ...
Authors:Yuk Lung Wong, Ingmar Lautenschläger, Karina Zitta, Christin Schildhauer, Kerstin Parczany, Christoph Röcken, Markus Steinfath, Norbert Weiler and Martin Albrecht
Citation:Journal of Translational Medicine 2016 14:60
Published on: 27 February 2016
- ViewFull Text
- ViewPDF
Content Type:Review
Stem/progenitor cells in endogenous repairing responses: new toolbox for the treatment of acute lung injury
The repair of organs and tissues has stepped into a prospective era of regenerative medicine. However, basic research and clinical practice in the lung regeneration remains crawling. Owing to the complicated t...
Authors:Ce Yang, Jianxin Jiang, Xuetao Yang, Haiyan Wang and Juan Du
Citation:Journal of Translational Medicine 2016 14:47
Published on: 11 February 2016
- ViewFull Text
- ViewPDF
Content Type:Research
Effectiveness of pure argon for renal transplant preservation in a preclinical pig model of heterotopic autotransplantation
In kidney transplantation, the conditions of organ preservation following removal influence function recovery. Current static preservation procedures are generally based on immersion in a cold-storage solution...
Authors:Alice Faure, Laurie Bruzzese, Jean-Guillaume Steinberg, Yves Jammes, Julia Torrents, Stephane V. Berdah, Emmanuelle Garnier, Tristan Legris, Anderson Loundou, Matthieu Chalopin, Guy Magalon, Regis Guieu, Emmanuel Fenouillet and Eric Lechevallier
Citation:Journal of Translational Medicine 2016 14:40
Published on: 4 February 2016
- ViewFull Text
- ViewPDF
Content Type:Research
Induction of heme oxygenase-1 by hemin protects lung against orthotopic autologous liver transplantation-induced acute lung injury in rats
Post-liver transplantation acute lung injury (ALI) severely affects patients’ survival, whereas the mechanism is unclear and effective therapy is lacking. The authors postulated that reperfusion-induced increa...
Authors:Xinjin Chi, Na Guo, Weifeng Yao, Yi Jin, Wanling Gao, Jun Cai and Ziqing Hei
Citation:Journal of Translational Medicine 2016 14:35
Published on: 2 February 2016
- ViewFull Text
- ViewPDF
Content Type:Commentary
Individualized real-time clinical decision support to monitor cardiac loading during venoarterial ECMO
Veno-arterial extracoporeal membrane oxygenation (VA ECMO) is increasingly used for acute and refractory cardiogenic shock. Yet, in clinical practice, monitoring of cardiac loading conditions during VA ECMO ca...
Authors:Michael Broomé and Dirk W. Donker
Citation:Journal of Translational Medicine 2016 14:4
Published on: 6 January 2016
- ViewFull Text
- ViewPDF
Content Type:Research
Nerve detection with optical spectroscopy for regional anesthesia procedures
Regional anesthesia has several advantages over general anesthesia but requires accurate needle placement to be effective. To achieve accurate placement, a needle equipped with optical fibers that allows tiss...
Authors:Benno H. W. Hendriks, Andrea J. R. Balthasar, Gerald W. Lucassen, Marjolein van der Voort, Manfred Mueller, Vishnu V. Pully, Torre M. Bydlon, Christian Reich, Arnold T. M. H. van Keersop, Jeroen Kortsmit, Gerrit C. Langhout and Geert-Jan van Geffen
Citation:Journal of Translational Medicine 2015 13:380
Published on: 15 December 2015
- ViewFull Text
- ViewPDF
Content Type:Research
Mother root of Aconitum carmichaelii Debeaux exerts antinociceptive effect in Complete Freund’s Adjuvant-induced mice: roles of dynorphin/kappa-opioid system and transient receptor potential vanilloid type-1 ion channel
Processed Chuanwu (PCW), the mother root of Aconitum carmichaelii Debeaux, has been widely used as a classic Traditional Chinese Medicine for pain relieve for over two millennia clinic...
Authors:Chao Wang, Danni Sun, Chunfang Liu, Chunyan Zhu, Xianghong Jing, Shuping Chen, Cuiling Liu, Kai Zhi, Tengfei Xu, Hui Wang, Junling Liu, Ying Xu, Zhiqiang Liu and Na Lin
Citation:Journal of Translational Medicine 2015 13:284
Published on: 30 August 2015
- ViewFull Text
- ViewPDF
Content Type:Research
Beneficial effects of levobupivacaine regional anaesthesia on postoperative opioid induced hyperalgesia in diabetic mice
Diabetic neuropathy is one of the most common complications of diabetes and causes various problems in daily life. The aim of this study was to assess the effect of regional anaesthesia on post surgery opioid ...
Authors:Anne Gomez-Brouchet, Nelly Blaes, Lionel Mouledous, Olivier Fourcade, Ivan Tack, Bernard Francès, Jean-Pierre Girolami and Vincent Minville
Citation:Journal of Translational Medicine 2015 13:208
Published on: 2 July 2015
- ViewFull Text
- ViewPDF
Content Type:Research
Dexmedetomidine ameliorates acute lung injury following orthotopic autologous liver transplantation in rats probably by inhibiting Toll-like receptor 4–nuclear factor kappa B signaling
To investigate whether pretreatment with dexmedetomidine (Dex) has a protective effect against acute lung injury (ALI) in an orthotopic autologous liver transplantation (OALT) rat model and to explore the mech...
Authors:Xinjin Chi, Xiaoxia Wei, Wanling Gao, Jianqiang Guan, Xiaofan Yu, Yiheng Wang, Xi Li and Jun Cai
Citation:Journal of Translational Medicine 2015 13:190
Published on: 13 June 2015
- ViewFull Text
- ViewPDF
Content Type:Research
Effects of hydrogen-rich saline on early acute kidney injury in severely burned rats by suppressing oxidative stress induced apoptosis and inflammation
Early acute kidney injury (AKI) in severely burned patients predicts a high mortality that is multi-factorial. Hydrogen has been reported to alleviate organ injury via selective quenching of reactive oxygen sp...
Authors:Song-Xue Guo, Quan Fang, Chuan-Gang You, Yun-Yun Jin, Xin-Gang Wang, Xin-Lei Hu and Chun-Mao Han
Citation:Journal of Translational Medicine 2015 13:183
Published on: 6 June 2015
- ViewFull Text
- ViewPDF
Content Type:Research
Electroacupuncture stimulation at sub-specific acupoint and non-acupoint induced distinct brain glucose metabolism change in migraineurs: a PET-CT study
Acupuncture has analgesic effect to most pain conditions. Many neuroimaging studies were conducted to explore acupoint specificity in pain and other condition, but till now there is still discrepancy. Based on...
Authors:Mingxiao Yang, Jie Yang, Fang Zeng, Peng Liu, Zhenhong Lai, Shufang Deng, Li Fang, Wenzhong Song, Hongjun Xie and Fanrong Liang
Citation:Journal of Translational Medicine 2014 12:351
Published on: 12 December 2014
- ViewFull Text
- ViewPDF
Content Type:Editorial
Pain, Critical Care and Anesthesia section
No abstract
Authors:Yasin Said AlMakadma
Citation:Journal of Translational Medicine 2014 12:268
Published on: 8 October 2014
- ViewFull Text
- ViewPDF