Illnesses of Unknown Etiology

Section Edited by Monica C. Panelli

This section aims to provide a translational medicine forum for the publication of research on illnesses, multisystem diseases and syndromes of unknown etiology. Examples of these include Myalgic Encephalomyelitis (ME)/Chronic Fatigue Syndrome (CFS) and Fibromyalgia Syndrome (FMS).

There has been a continuous albeit undervalued progress in this arena. However, among the many medical specialties that try to diagnose and treat the multiple symptoms presented by patients affected by these diseases, an avenue of rapid and simultaneous communication is missing.

Studies on all aspects of ME/CFS and multi-system diseases of unknown cause with applications in medicine and biotechnology will be considered for publication. The section welcomes contributions that employ traditional clinical, metabolic, epidemiologic, genomics and proteomics methods as diagnostic and prognostic tools.

Content Type:Research
The expression signature of very long non-coding RNA in myalgic encephalomyelitis/chronic fatigue syndrome
Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a chronic debilitating disease with huge social-economic impact. It has been suggested that immune dysregulation, nitrooxidative stress, and metab...
Authors:Chin-An Yang, Sandra Bauer, Yu-Chen Ho, Franziska Sotzny, Jan-Gowth Chang and Carmen Scheibenbogen
Citation:Journal of Translational Medicine 2018 16:231
Published on: 17 August 2018
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Content Type:Research
Exhaustion of mitochondrial and autophagic reserve may contribute to the development of LRRK2 G2019S -Parkinson’s disease
Mutations in leucine rich repeat kinase 2 (LRRK2) are the most common cause of familial Parkinson’s disease (PD). Mitochondrial and autophagic dysfunction has been described as etiologic factors in different expe...
Authors:Diana Luz Juárez-Flores, Ingrid González-Casacuberta, Mario Ezquerra, María Bañó, Francesc Carmona-Pontaque, Marc Catalán-García, Mariona Guitart-Mampel, Juan José Rivero, Ester Tobias, Jose Cesar Milisenda, Eduard Tolosa, Maria Jose Marti, Ruben Fernández-Santiago, Francesc Cardellach, Constanza Morén and Glòria Garrabou
Citation:Journal of Translational Medicine 2018 16:160
Published on: 8 June 2018
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Content Type:Research
Association of chronic fatigue syndrome with premature telomere attrition
Chronic fatigue syndrome (CFS), also known as myalgic encephalomyelitis (ME), is a severely debilitating condition of unknown etiology. The symptoms and risk factors of ME/CFS share features of accelerated agi...
Authors:Mangalathu S. Rajeevan, Janna Murray, Lisa Oakley, Jin-Mann S. Lin and Elizabeth R. Unger
Citation:Journal of Translational Medicine 2018 16:44
Published on: 27 February 2018
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Content Type:Research
Identification of candidate genes associated with fibromyalgia susceptibility in southern Spanish women: the al-Ándalus project
Candidate-gene studies on fibromyalgia susceptibility often include a small number of single nucleotide polymorphisms (SNPs), which is a limitation. Moreover, there is a paucity of evidence in Europe. Therefor...
Authors:Fernando Estévez-López, Daniel Camiletti-Moirón, Virginia A. Aparicio, Víctor Segura-Jiménez, Inmaculada C. Álvarez-Gallardo, Alberto Soriano-Maldonado, Milkana Borges-Cosic, Pedro Acosta-Manzano, Rinie Geenen, Manuel Delgado-Fernández, Luis J. Martínez-González, Jonatan R. Ruiz and María J. Álvarez-Cubero
Citation:Journal of Translational Medicine 2018 16:43
Published on: 27 February 2018
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Content Type:Research
Open-label pilot for treatment targeting gut dysbiosis in myalgic encephalomyelitis/chronic fatigue syndrome: neuropsychological symptoms and sex comparisons
Preliminary evidence suggests that the enteric microbiota may play a role in the expression of neurological symptoms in myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS). Overlapping symptoms with th...
Authors:Amy Wallis, Michelle Ball, Henry Butt, Donald P. Lewis, Sandra McKechnie, Phillip Paull, Amber Jaa-Kwee and Dorothy Bruck
Citation:Journal of Translational Medicine 2018 16:24
Published on: 6 February 2018
The Correction to this article has been published in Journal of Translational Medicine 2018 16:39
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Content Type:Research
Improvement of severe myalgic encephalomyelitis/chronic fatigue syndrome symptoms following surgical treatment of cervical spinal stenosis
Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a potentially disabling disorder. Little is known about the contributors to severe forms of the illness. We describe three consecutive patients wi...
Authors:Peter C. Rowe, Colleen L. Marden, Scott Heinlein and Charles C. Edwards II
Citation:Journal of Translational Medicine 2018 16:21
Published on: 2 February 2018
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Content Type:Editorial
JTM advances in uncharted territories: diseases and disorders of unknown etiology
We are delighted to announce a new section in the Journal of Translational Medicine, ‘Illnesses of Unknown Etiology’. This section aims to provide a translational medicine forum for the publication of research on...
Authors:Monica C. Panelli
Citation:Journal of Translational Medicine 2017 15:192
Published on: 13 September 2017
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Content Type:Review
The European ME/CFS Biomarker Landscape project: an initiative of the European network EUROMENE
Myalgic encephalomyelitis or chronic fatigue syndrome (ME/CFS) is a common and severe disease with a considerable social and economic impact. So far, the etiology is not known, and neither a diagnostic marker ...
Authors:Carmen Scheibenbogen, Helma Freitag, Julià Blanco, Enrica Capelli, Eliana Lacerda, Jerome Authier, Mira Meeus, Jesus Castro Marrero, Zaiga Nora-Krukle, Elisa Oltra, Elin Bolle Strand, Evelina Shikova, Slobodan Sekulic and Modra Murovska
Citation:Journal of Translational Medicine 2017 15:162
Published on: 26 July 2017
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