sábado, 26 de enero de 2019

Journal of Translational Medicine | Neuroscience

Journal of Translational Medicine | Neuroscience



Neuroscience

Section edited by Luis F. Alguacil
The Neuroscience section aims to encourage publications that help to reduce the gap between basic preclinical science and medical applications for the patients in the neuroscience field.
  1. Content Type:Research

    Glioblastoma multiform (GBM) is a devastating brain tumor with maximum surgical resection, radiotherapy plus concomitant and adjuvant temozolomide (TMZ) as the standard treatment. Diverse clinicopathological a...
    Authors:Wei-Zhen Gao, Lie-Mei Guo, Tian-Qi Xu, Yu-Hua Yin and Feng Jia
    Citation:Journal of Translational Medicine 2018 16:368
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  2. Content Type:Research

    Neurogenic bowel dysfunction (NBD) is a major physical and psychological problem in patients with spinal cord injury (SCI), and gut dysbiosis is commonly occurs in SCI. Here, we document neurogenic bowel manag...
    Authors:Chao Zhang, Wenhao Zhang, Jie Zhang, Yingli Jing, Mingliang Yang, Liangjie Du, Feng Gao, Huiming Gong, Liang Chen, Jun Li, Hongwei Liu, Chuan Qin, Yanmei Jia, Jiali Qiao, Bo Wei, Yan Yu…
    Citation:Journal of Translational Medicine 2018 16:353
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  3. Content Type:Research

    Acute ischemic stroke is a leading cause of mortality and long-term disability, and profiles of endothelial progenitor cells (EPCs) reflect the degree of endothelial impairment. This study tested the hypothesi...
    Authors:Chen-Yu Chen, Re-Wen Wu, Nai-Wen Tsai, Mel S. Lee, Wei-Che Lin, Mei-Chi Hsu, Chih-Cheng Huang, Yun-Ru Lai, Chia-Te Kung, Hung-Chen Wang, Yu-Jih Su, Chih-Min Su, Sheng-Yuan Hsiao, Ben-Chung Cheng, Yi-Fang Chiang and Cheng-Hsien Lu
    Citation:Journal of Translational Medicine 2018 16:255
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  4. Content Type:Research

    Fatigue is a common problem among individuals with Parkinson’s disease (PD). It may occur before the overt symptoms of bradykinesia, rigidity and tremor. Little is understood about how to measure fatigue in PD...
    Authors:Raymond Chong, Lauren Albor, Chandramohan Wakade and John Morgan
    Citation:Journal of Translational Medicine 2018 16:192
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  5. Content Type:Research

    For nearly four decades, the N400 has been an important brainwave marker of semantic processing. It can be recorded non-invasively from the scalp using electrical and/or magnetic sensors, but largely within th...
    Authors:Sujoy Ghosh Hajra, Careesa C. Liu, Xiaowei Song, Shaun D. Fickling, Teresa P. L. Cheung and Ryan C. N. D’Arcy
    Citation:Journal of Translational Medicine 2018 16:151
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  6. Content Type:Research

    Mental illness contributes substantially to global disease burden, particularly when illness onset occurs during youth and help-seeking is delayed and/or limited. Yet, few mental health promotion interventions...
    Authors:Joanna Yang, Roberto Lopez Cervera, Susannah J. Tye, Stephen C. Ekker and Chris Pierret
    Citation:Journal of Translational Medicine 2018 16:84
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  7. Content Type:Research

    Magnetic stimulation of the facial nerve has been tested in preclinical studies as a new, non-invasive emergency treatment of ischemic stroke that acts by increasing cerebral blood flow (CBF). The objective of...
    Authors:Olivia Sanchez, Andrea García, Fernando Castro-Prado, Miriam Perez, Rafael Lara-Estrada, Martin Ramirez-Meza, Montserrat Godinez, Michael L. Coco, Joaquín Azpiroz, Mark K. Borsody and Emilio Sacristán
    Citation:Journal of Translational Medicine 2018 16:27
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  9. Content Type:Research

    Hearing loss and ovarian dysfunction are key features of Perrault syndrome (PRLTS) but the clinical and pathophysiological features of hearing impairment in PRLTS individuals have not been addressed. Mutations...
    Authors:Monika Ołdak, Dominika Oziębło, Agnieszka Pollak, Iwona Stępniak, Michal Lazniewski, Urszula Lechowicz, Krzysztof Kochanek, Mariusz Furmanek, Grażyna Tacikowska, Dariusz Plewczynski, Tomasz Wolak, Rafał Płoski and Henryk Skarżyński
    Citation:Journal of Translational Medicine 2017 15:25
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  10. Content Type:Research

    Studies have indicated that bone marrow stromal cell (BMSC) administration is a promising approach for stroke treatment. For our study, we chose sodium ferulate (SF) and n-butylidenephthalide (BP) combined with B...
    Authors:Qian Zhang, Yonghua Zhao, Youhua Xu, Zhenwei Chen, Naiwei Liu, Chienchih Ke, Bowen Liu and Weikang Wu
    Citation:Journal of Translational Medicine 2016 14:223
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  11. Content Type:Research

    Systemic inflammation, neurocognitive impairments, and morphologic brain changes are associated with obstructive sleep apnea (OSA). Understanding their longitudinal evolution and interactions after surgical tr...
    Authors:Wei-Che Lin, Chih-Cheng Huang, Hsiu-Ling Chen, Kun-Hsien Chou, Pei-Chin Chen, Nai-Wen Tsai, Meng-Hsiang Chen, Michael Friedman, Hsin-Ching Lin and Cheng-Hsien Lu
    Citation:Journal of Translational Medicine 2016 14:139
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  12. Content Type:Research

    Vagus nerve stimulation (VNS) has become the most common non-pharmacological treatment for intractable drug-resistant epilepsy. However, the contribution of VNS to neurological rehabilitation following stroke ...
    Authors:Ai-fen Liu, Feng-bo Zhao, Jing Wang, Yi-Fan Lu, Jian Tian, Yin Zhao, Yan Gao, Xia-jun Hu, Xiao-yan Liu, Jie Tan, Yun-li Tian and Jing Shi
    Citation:Journal of Translational Medicine 2016 14:101
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  13. Content Type:Research

    It is generally acknowledged that drug dependence is connected with abnormal functional organization in the individual’s brain. The present study aimed to identify the anterior cingulate cortex (ACC) abnormali...
    Authors:Tao Liu, Jianjun Li, Zhongyan Zhao, Yuan Zhong, Zhiqiang Zhang, Qiang Xu, Guoshuai Yang, Guangming Lu, Suyue Pan and Feng Chen
    Citation:Journal of Translational Medicine 2016 14:33
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  14. Content Type:Research

    Autosomal recessive non-syndromic hearing loss (ARNSHL) is highly heterogeneous, and mutations in the gene encoding transmembrane channel-like 1 (TMC1) have been implicated in its development. To date, 35 homo...
    Authors:Jiongjiong Hu, Fei Liu, Wenjun Xia, Lili Hao, Jun Lan, Zhenghua Zhu, Jing Ye, Duan Ma and Zhaoxin Ma
    Citation:Journal of Translational Medicine 2016 14:29
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  15. Content Type:Research

    Preclinical trials have shown beneficial effects of nerve growth factor (NGF) administration on visual function in animal models of retinitis pigmentosa (RP). The aim of this pilot study was to explore the po...
    Authors:Benedetto Falsini, Giancarlo Iarossi, Antonio Chiaretti, Antonio Ruggiero, Luigi Manni, Lucia Galli-Resta, Giovanni Corbo and Edoardo Abed
    Citation:Journal of Translational Medicine 2016 14:8
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    The Erratum to this article has been published in Journal of Translational Medicine 2016 14:43
  16. Content Type:Research

    Parkinson’s disease (PD) is well documented to be associated with elevated systemic oxidative stress and perceptual impairments. Furthermore, the striatum and extrastriatal cortical areas, which are involved i...
    Authors:Wei-Che Lin, Kun-Hsien Chou, Pei-Lin Lee, Yung-Cheng Huang, Nai-Wen Tsai, Hsiu-Ling Chen, Kuei-Yueh Cheng, Hung-Chen Wang, Tsu-Kung Lin, Shau-Hsuan Li, Meng-Hsiang Chen, Cheng-Hsien Lu and Ching-Po Lin
    Citation:Journal of Translational Medicine 2015 13:386
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  17. Content Type:Research

    Autophagy is demonstrated to be involved in acute ischemic stroke(AIS), which, however, is confined to cells and/or animals levels. The aim of this study was to determine two autophagy biomarkers, Beclin1 and ...
    Authors:Honghong Li, Shuwei Qiu, Xiangpen Li, Mei Li and Ying Peng
    Citation:Journal of Translational Medicine 2015 13:359
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  18. Content Type:Research

    There is a paucity of effective therapies for recurrent/aggressive meningiomas. Establishment of improved in vitro and in vivo meningioma models will facilitate development and testing of novel therapeutic app...
    Authors:Sharon K Michelhaugh, Anthony R Guastella, Kaushik Varadarajan, Neil V Klinger, Prahlad Parajuli, Aamir Ahmad, Seema Sethi, Amro Aboukameel, Sam Kiousis, Ian M Zitron, Salah A Ebrahim, Lisa A Polin, Fazlul H Sarkar, Aliccia Bollig-Fischer and Sandeep Mittal
    Citation:Journal of Translational Medicine 2015 13:227
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  19. Content Type:Research

    Schizophrenia is a widespread and debilitating mental disorder. However, the underlying molecular mechanism of schizophrenia remains largely unknown and no objective laboratory tests are available to diagnose ...
    Authors:Mei-Ling Liu, Xiao-Tong Zhang, Xiang-Yu Du, Zheng Fang, Zhao Liu, Yi Xu, Peng Zheng, Xue-Jiao Xu, Peng-Fei Cheng, Ting Huang, Shun-Jie Bai, Li-Bo Zhao, Zhi-Guo Qi, Wei-Hua Shao and Peng Xie
    Citation:Journal of Translational Medicine 2015 13:226
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  20. Content Type:Research

    Rodents are incapable of emesis and consequently the emetic potential of glucagon-like peptide-1 receptor (GLP-1R) agonists in studies designed to assess a potential blood glucose lowering action of the compou...
    Authors:Zengbing Lu, Nathalie Percie Du Sert, Sze Wa Chan, Chi-Kong Yeung, Ge Lin, David TW Yew, Paul LR Andrews and John A Rudd
    Citation:Journal of Translational Medicine 2014 12:327
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  21. Content Type:Research

    A cochlear implant (CI) is an artificial hearing device that can replace a damaged cochlea. The present study examined the use of growth factor-eluting gelatin hydrogel coatings on the electrodes to minimize i...
    Authors:Yayoi S Kikkawa, Takayuki Nakagawa, Lin Ying, Yasuhiko Tabata, Hirohito Tsubouchi, Akio Ido and Juichi Ito
    Citation:Journal of Translational Medicine 2014 12:280
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  22. Content Type:Research

    our objective was to examine the plasma levels of three biological markers involved in cerebral ischemia (IL-6, glutamate and TNF-alpha) in stroke patients and compare them with two different rat models of foc...
    Authors:Patricia Martínez-Sánchez, María Gutiérrez-Fernández, Blanca Fuentes, Jaime Masjuán, María Alonso de Leciñana Cases, Maria Elena Novillo-López and Exuperio Díez-Tejedor
    Citation:Journal of Translational Medicine 2014 12:220
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  23. Content Type:Research

    Prevailingly, adult mammalian neurogenesis is thought to occur in discrete, separate locations known as neurogenic niches that are best characterized in the subgranular zone (SGZ) of the dentate gyrus and in t...
    Authors:Adriano Barreto Nogueira, Mari Cleide Sogayar, Alison Colquhoun, Sheila Aparecida Siqueira, Ariel Barreto Nogueira, Paulo Eurípedes Marchiori and Manoel Jacobsen Teixeira
    Citation:Journal of Translational Medicine 2014 12:75
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  24. Content Type:Research

    Racial and regional factors are important for the clinical diagnosis of non-syndromic hearing impairment. Comprehensive genetic analysis of deaf patients in different regions of China must be performed to prov...
    Authors:Kaitian Chen, Ling Zong, Min Liu, Xianren Wang, Wei Zhou, Yuan Zhan, Hui Cao, Chang Dong, Haocheng Tang and Hongyan Jiang
    Citation:Journal of Translational Medicine 2014 12:64
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  25. Content Type:Research

    Inherited genetic defects play an important role in congenital hearing loss, contributing to about 60% of deafness occurring in infants. Hereditary nonsyndromic hearing loss is highly heterogeneous, and most p...
    Authors:Xue Gao, Qing-yan Zhu, Yue-Shuai Song, Guo-Jian Wang, Yong-Yi Yuan, Feng Xin, Sha-Sha Huang, Dong-Yang Kang, Ming-Yu Han, Li-ping Guan, Jian-guo Zhang and Pu Dai
    Citation:Journal of Translational Medicine 2013 11:284
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  26. Content Type:Research

    MicroRNAs have recently emerged as key regulators of cancers, miR-329 located on 14q32.31 is one of down-regulated miRNAs in glioma, but the function and molecular mechanisms of miR-329 in determining the mali...
    Authors:Bingxiang Xiao, Li Tan, Benfu He, Zhiliang Liu and Ruxiang Xu
    Citation:Journal of Translational Medicine 2013 11:172
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  27. Content Type:Research

    When patients with ocular motor deficits come to the clinic, in numerous situations it is hard to relate their behavior to one or several deficient neural structures. We sought to demonstrate that neuromimetic...
    Authors:Pierre M Daye, Lance M Optican, Emmanuel Roze, Bertrand Gaymard and Pierre Pouget
    Citation:Journal of Translational Medicine 2013 11:125
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  28. Content Type:Methodology

    Neurodegenerative diseases such as Alzheimer’s are associated with the aggregation of endogenous peptides and proteins that contribute to neuronal dysfunction and loss. The glymphatic system, a brain-wide peri...
    Authors:Lijun Yang, Benjamin T Kress, Harris J Weber, Meenakshisundaram Thiyagarajan, Baozhi Wang, Rashid Deane, Helene Benveniste, Jeffrey J Iliff and Maiken Nedergaard
    Citation:Journal of Translational Medicine 2013 11:107
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  29. Content Type:Research

    Flupirtine is an analgesic with muscle-relaxing properties that activates Kv7 potassium channels. Kv7 channels are expressed along myelinated and unmyelinated peripheral axons where their activation is expecte...
    Authors:Johannes Fleckenstein, Ruth Sittl, Beate Averbeck, Philip M Lang, Dominik Irnich and Richard W Carr
    Citation:Journal of Translational Medicine 2013 11:34
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  30. Content Type:Review

    The physiological role of the neurotrophin nerve growth factor (NGF) has been characterized, since its discovery in the 1950s, first in the sensory and autonomic nervous system, then in central nervous, endocr...
    Authors:Luigi Aloe, Maria Luisa Rocco, Patrizia Bianchi and Luigi Manni
    Citation:Journal of Translational Medicine 2012 10:239
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  31. Content Type:Research

    Alzheimer’s Disease (AD) is the most widespread form of dementia in the elderly but despite progress made in recent years towards a mechanistic understanding, there is still an urgent need for disease modifica...
    Authors:Ines Greco, Nicola Day, Joanna Riddoch-Contreras, Jane Reed, Hilkka Soininen, Iwona Kłoszewska, Magda Tsolaki, Bruno Vellas, Christian Spenger, Patrizia Mecocci, Lars-Olof Wahlund, Andrew Simmons, Julie Barnes and Simon Lovestone
    Citation:Journal of Translational Medicine 2012 10:217
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  33. Content Type:Research

    Leber hereditary optic neuropathy (LHON) is a mitochondrial disorder with gender biased and incomplete penetrance. The majority of LHON patients are caused by one of the three primary mutations (m.3460G > A, m...
    Authors:A-Mei Zhang, Xiaoyun Jia, Xiangming Guo, Qingjiong Zhang and Yong-Gang Yao
    Citation:Journal of Translational Medicine 2012 10:43
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  35. Content Type:Research

    Methylation of the O6-methylguanine-DNA methyltransferase (MGMT) gene promoter is a favorable prognostic factor in glioblastoma patients. However, reported methylation frequencies vary significantly partly due to...
    Authors:Annette Bentsen Håvik, Petter Brandal, Hilde Honne, Hanne-Sofie Spenning Dahlback, David Scheie, Merete Hektoen, Torstein Ragnar Meling, Eirik Helseth, Sverre Heim, Ragnhild A Lothe and Guro Elisabeth Lind
    Citation:Journal of Translational Medicine 2012 10:36
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  36. Content Type:Research

    Exosomes are released from multiple cell types, contain protein and RNA species, and have been exploited as a novel reservoir for disease biomarker discovery. They can transfer information between cells and ma...
    Authors:Jonathan M Street, Perdita E Barran, C Logan Mackay, Stefan Weidt, Craig Balmforth, Tim S Walsh, Rod TA Chalmers, David J Webb and James W Dear
    Citation:Journal of Translational Medicine 2012 10:5
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  37. Content Type:Research

    Aberrant expression of small noncoding RNAs called microRNAs (miRNAs) is a common feature of several human diseases. The objective of the study was to identify miRNA modulation in patients with complex regiona...
    Authors:Irina A Orlova, Guillermo M Alexander, Rehman A Qureshi, Ahmet Sacan, Alessandro Graziano, James E Barrett, Robert J Schwartzman and Seena K Ajit
    Citation:Journal of Translational Medicine 2011 9:195
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