jueves, 1 de agosto de 2019

BMC Cancer | Cell and molecular biology

BMC Cancer | Cell and molecular biology

BMC Cancer

Cell and molecular biology

This section covers all aspects of tumor biology from a molecular and cellular point of view. Topics of interest include, but are not limited to, animal models, hypoxia, angiogenesis, metastasis, cellular signaling, cancer stem cells, DNA damage and repair, cell cycle and apoptosis.
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  1. Content Type:Research Article

    Doxorubicin is currently the most effective chemotherapeutic drug used to treat breast cancer. It has, however, been shown that doxorubicin can induce drug resistance resulting in poor patient prognosis and su...
    Authors:Claudia Christowitz, Tanja Davis, Ashwin Isaacs, Gustav van Niekerk, Suzel Hattingh and Anna-Mart Engelbrecht
    Citation:BMC Cancer 2019 19:757
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  3. Content Type:Research Article

    Human inflammatory breast cancer (IBC) and canine inflammatory mammary cancer (IMC) are the most lethal mammary cancers. An exacerbated angiogenesis and the existence of vasculogenic mimicry (VM) are hallmarks...
    Authors:Lucía Barreno, Sara Cáceres, Ángela Alonso-Diez, Ana Vicente-Montaña, María Luisa García, Mónica Clemente, Juan Carlos Illera and Laura Peña
    Citation:BMC Cancer 2019 19:750
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  4. Content Type:Research Article

    Emerging evidence has shown that miR-1275 plays a critical role in tumour metastasis and the progression of various types of cancer. In this study, we analysed the role and mechanism of miR-1275 in the progres...
    Authors:Jia-Wei Mei, Zi-Yi Yang, Hong-Gang Xiang, Runfa Bao, Yuan-Yuan Ye, Tai Ren, Xue-Feng Wang and Yi-Jun Shu
    Citation:BMC Cancer 2019 19:740
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  5. Content Type:Research Article

    Breast cancer is the most common cancer type in female. As microRNAs play vital role in breast cancer, this study aimed to explore the molecular mechanism and clinical value of miR-21 in breast cancer.
    Authors:Hui Wang, Zheqiong Tan, Hui Hu, Hongzhou Liu, Tangwei Wu, Chao Zheng, Xiuling Wang, Zhenzhao Luo, Jing Wang, Shuiyi Liu, Zhongxin Lu and Jiancheng Tu
    Citation:BMC Cancer 2019 19:738
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  6. Content Type:Research Article

    SET domain containing 5 (SETD5) is related to the aggressiveness of prostate and mammary cancers, but its association with non-small cell lung cancer (NSCLC) is unknown. Therefore, the purpose of this research...
    Authors:Hairu Yu, Jiayi Sun, Congxuan Zhao, Haotian Wang, Yeqiu Liu, Jiajia Xiong, Jing Chang, Mixue Wang, Wenhui Wang, Dongman Ye, Hongyan Zhou and Tao Yu
    Citation:BMC Cancer 2019 19:736
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  7. Content Type:Research Article

    Emerging evidence indicates that Long non-coding RNAs (LncRNAs) and microRNAs (miRNAs) play crucial roles in tumor progression, including hepatocellular carcinoma (HCC). However, whether there is a crosstalk b...
    Authors:Qiang Zhou, Wei Zhang, Zhongfeng Wang and Songyang Liu
    Citation:BMC Cancer 2019 19:731
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  8. Content Type:Research Article

    Breast cancer currently is the most frequently diagnosed neoplasm and the leading cause of death from cancer in women worldwide, which is mainly due to metastatic disease. Increasing our understanding of the m...
    Authors:José Esparza-López, Juan Francisco Alvarado-Muñoz, Elizabeth Escobar-Arriaga, Alfredo Ulloa-Aguirre and María de Jesús Ibarra-Sánchez
    Citation:BMC Cancer 2019 19:728
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  9. Content Type:Research Article

    Copy number gain of the D-3-phosphoglycerate dehydrogenase (PHGDH) gene, which encodes the first enzyme in serine biosynthesis, is found in some human cancers including a subset of melanomas.
    Authors:Katherine R. Mattaini, Mark R. Sullivan, Allison N. Lau, Brian P. Fiske, Roderick T. Bronson and Matthew G. Vander Heiden
    Citation:BMC Cancer 2019 19:723
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  10. Content Type:Research Article

    Tongue squamous cell carcinoma (TSCC) is a special type of oral cancer. Cervical lymph node relapse may occur in a large percentage of TSCC patients, which usually indicates poor prognosis. In this cohort stud...
    Authors:Kailiu Wu, Junshui Wei, Zhengwu Liu, Binbin Yu, Xi Yang, Chunye Zhang, Ahmed Abdelrehem, Chenping Zhang and Siyi Li
    Citation:BMC Cancer 2019 19:714
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  11. Content Type:Research Article

    Identification of molecular markers for early detection or prediction of metastasis is crucial for both management of HCC patient postoperative treatment and identify new therapeutic targets to inhibit HCC pro...
    Authors:Lui Ng, Virginia Kwan, Ariel Chow, Thomas Chung-Cheung Yau, Ronnie Tung-Ping Poon, Roberta Pang and Wai-Lun Law
    Citation:BMC Cancer 2019 19:713
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  12. Content Type:Research Article

    Argonaute-2 (Ago2) is an essential component of microRNA biogenesis implicated in tumourigenesis. However Ago2 expression and localisation in breast cancer remains undetermined. The aim was to define Ago2 expr...
    Authors:M.C. Casey, A. Prakash, E. Holian, A. McGuire, O. Kalinina, A. Shalaby, C. Curran, M. Webber, G. Callagy, E. Bourke, M. J. Kerin and J. A. Brown
    Citation:BMC Cancer 2019 19:712
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  13. Content Type:Research Article

    Glioblastoma (GBM) is an extremely deadly form of brain cancer with limited treatment options and thus novel therapeutic modalities are necessary. Histone deacetylase inhibitors (HDACi) have demonstrated clini...
    Authors:Tian Ye, Liwen Wei, Ji Shi, Ke Jiang, Huizhe Xu, Lulu Hu, Lingkai Kong, Ye Zhang, Songshu Meng and Haozhe Piao
    Citation:BMC Cancer 2019 19:706
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  15. Content Type:Research Article

    Thyroid cancer is the most common endocrinology cancer that its incidence has increased in recent decades. miRNAs are new biomarkers in recent studies in the diagnosis and follow-up of these patients.
    Authors:Mahsa Rezaei, Amir Mahdi Khamaneh, Nosratollah Zarghami, Armin Vosoughi and Shahriar Hashemzadeh
    Citation:BMC Cancer 2019 19:690
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  16. Content Type:Research Article

    Re-capture of the differences between tumor and normal tissues observed at the patient level in cell cultures and animal models is critical for applications of these cancer-related differences. The epithelial-...
    Authors:Jing Song, Wenqing Wang, Yingyan Wang, Yongxin Qin, Yingzi Wang, Jian Zhou, Xuelian Wang, Yi Zhang and Qi Wang
    Citation:BMC Cancer 2019 19:680
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  17. Content Type:Research Article

    Although the prognosis of chronic myeloid leukemia (CML) has dramatically improved, the pathogenesis of CML remains elusive. Studies have shown that sustained phosphorylation of AKT1 plays a crucial role in th...
    Authors:Xiaorong Liu, Huirong Mai, Hanfang Jiang, Zhihao Xing, Dong Peng, Yuan Kong, Chunqing Zhu and Yunsheng Chen
    Citation:BMC Cancer 2019 19:679
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  18. Content Type:Research Article

    In epithelial cells, tyrosine kinases induce tyrosine phosphorylation and ubiquitination of the E-cadherin complex, which is responsible for the epithelial-mesenchymal transition (EMT). However, the precise me...
    Authors:Yunfeng Zhang, Liangzhang Sun, Xiao Gao, Aining Guo, Yan Diao and Yang Zhao
    Citation:BMC Cancer 2019 19:670
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  19. Content Type:Research Article

    Cancer is a rapidly evolving, multifactorial disease that accumulates numerous genetic and epigenetic alterations. This results in molecular and phenotypic heterogeneity within the tumor, the complexity of whi...
    Authors:Ana Martín-Pardillos, Ángeles Valls Chiva, Gemma Bande Vargas, Pablo Hurtado Blanco, Roberto Piñeiro Cid, Pedro J. Guijarro, Stefan Hümmer, Eva Bejar Serrano, Aitor Rodriguez-Casanova, Ángel Diaz-Lagares, Josep Castellvi, Samuel Miravet-Verde, Luis Serrano, María Lluch-Senar, Víctor Sebastian, Ana Bribian…
    Citation:BMC Cancer 2019 19:666
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  20. Content Type:Research Article

    Expression of Bcr-Abl in hematopoietic stem cells is sufficient to cause chronic myeloid leukemia (CML) and tyrosine kinase inhibitors (TKI) induce molecular remission in the majority of CML patients. However,...
    Authors:Oliver Herrmann, Maja Kim Kuepper, Marlena Bütow, Ivan G. Costa, Iris Appelmann, Fabian Beier, Tom Luedde, Till Braunschweig, Steffen Koschmieder, Tim H. Brümmendorf and Mirle Schemionek
    Citation:BMC Cancer 2019 19:658
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  21. Content Type:Research Article

    Aneuploidy of chromosome 8 in circulating tumor cells (CTCs) has been reported correlates with therapeutic efficacy and prognosis in patients with advanced gastric cancer. However, it is not clear whether it i...
    Authors:Yingjie Chen, Zhipeng Yang, Yingxue Wang, Juandong Wang and Chuanxin Wang
    Citation:BMC Cancer 2019 19:651
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  22. Content Type:Research Article

    DNA aneuploidy has attracted growing interest in clinical practice. Nevertheless, its prognostic value in gastric cancer patients remains controversial. This meta-analysis aims to explore the impact of DNA plo...
    Authors:Jing Xu, Ruolin Zhu, Lulu Fan, Shangqing Ge, Wei Wei, Xiaoqiu Li, Liangshan Da, Zhenya Jia, Zhiyan Zhao, Jie Ning, Jie Da, Wanren Peng, Kangsheng Gu and Guoping Sun
    Citation:BMC Cancer 2019 19:650
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  23. Content Type:Research Article

    Recently, long non-coding RNAs (lncRNAs) were considered as important gene expression regulators involving various biological processes. In this study, we explored the role of lncRNAs in the pathogenesis of ra...
    Authors:Ju-Mei Zhou, Rong Liang, Su-Yu Zhu, Hui Wang, Min Zou, Wei-Jing Zou and Shao-Lin Nie
    Citation:BMC Cancer 2019 19:647
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  24. Content Type:Research Article

    Ovarian cancer (OC) is the second most frequent gynecological cancer and is associated with a poor prognosis because OC progression is often asymptoma-tic and is detected at a late stage. There remains an urge...
    Authors:Bin Liu, Xiaojie Huang, Yifang Li, Weiguo Liao, Mingyi Li, Yi Liu, Rongrong He, Du Feng, Runzhi Zhu and Hiroshi Kurihara
    Citation:BMC Cancer 2019 19:645
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  25. Content Type:Research Article

    Altered expression of microRNAs (miRNAs) is known to contribute to cancer progression. miR-23b and miR-27b, encoded within the same miRNA cluster, are reported to have both tumor suppressive and oncogenic acti...
    Authors:Bethany N. Hannafon, Angela Cai, Cameron L. Calloway, Yi-Fan Xu, Roy Zhang, Kar-Ming Fung and Wei-Qun Ding
    Citation:BMC Cancer 2019 19:642
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  26. Content Type:Research Article

    Globally, the incidence and mortality rates of gastric cancer are high, and its poor prognosis is closely related to tumor recurrence and metastasis. Therefore, the molecular mechanisms associated with the mig...
    Authors:Yaoyue Qi, Jing Lv, Shihai Liu, Libin Sun, Yixuan Wang, Hui Li, Weiwei Qi and Wensheng Qiu
    Citation:BMC Cancer 2019 19:630
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  27. Content Type:Research Article

    Despite latest advances in prostate cancer (PCa) therapy, PCa remains the third-leading cause of cancer-related death in European men. Dysregulation of microRNAs (miRNAs), small non-coding RNA molecules with g...
    Authors:Mirjam Kiener, Lanpeng Chen, Markus Krebs, Joël Grosjean, Irena Klima, Charis Kalogirou, Hubertus Riedmiller, Burkhard Kneitz, George N. Thalmann, Ewa Snaar-Jagalska, Martin Spahn, Marianna Kruithof-de Julio and Eugenio Zoni
    Citation:BMC Cancer 2019 19:627
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  28. Content Type:Research Article

    Ovarian cancer is the most common malignant tumor of the female reproductive tract. Chemoresistance is a major challenge for current ovarian cancer therapy. However, the mechanism underlying epithelial ovarian...
    Authors:Junli Deng, Xupeng Bai, Xiaojie Feng, Jie Ni, Julia Beretov, Peter Graham and Yong Li
    Citation:BMC Cancer 2019 19:618
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  29. Content Type:Research Article

    Esophageal squamous cell carcinoma (ESCC) is the major subtype of esophageal cancer with high aggressiveness and poor prognosis. There is an urgent need for understanding the molecular mechanism underlying the...
    Authors:Bo Zeng, Xin Zhang, Jingling Zhao, Zhewei Wei, Haoshuai Zhu, Minyi Fu, Dawei Zou, Yanfen Feng, Honghe Luo and Yiyan Lei
    Citation:BMC Cancer 2019 19:609
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  30. Content Type:Research Article

    The prognosis of bladder urothelial carcinoma (BLCA) varies greatly among patients, and conventional pathological predictors are generally inadequate and often inaccurate to predict the heterogeneous behavior ...
    Authors:Shuxiong Zeng, Anwei Liu, Lihe Dai, Xiaowen Yu, Zhensheng Zhang, Qiao Xiong, Jun Yang, Fei Liu, Jinshan Xu, Yongping Xue, Yinghao Sun and Chuanliang Xu
    Citation:BMC Cancer 2019 19:604
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  31. Content Type:Research Article

    NANOS3 is a gene conserved throughout evolution. Despite the quite low conservation of Nanos sequences between different organisms and even between Nanos paralogs, their role in germ cell development is remarkabl...
    Authors:Vanessa Andries, Evi De Keuckelaere, Katrien Staes, Tino Hochepied, Joachim Taminau, Kelly Lemeire, Philippe Birembaut, Geert Berx and Frans van Roy
    Citation:BMC Cancer 2019 19:598
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  32. Content Type:Research Article

    S100A8 and S100A9, two heterodimer-forming members of the S100 family, aberrantly express in a variety of cancer types. However, little is known about the mechanism that regulates S100A8/S100A9 co-expression i...
    Authors:Yunguang Li, Fei Kong, Chang Jin, Enze Hu, Qirui Shao, Jin Liu, Dacheng He and Xueyuan Xiao
    Citation:BMC Cancer 2019 19:597
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  33. Content Type:Research Article

    Gemcitabine remains a cornerstone in chemotherapy of pancreatic ductal adenocarcinoma (PDAC) despite suboptimal clinical effects that are partly due to the development of chemoresistance. Pancreatic stellate c...
    Authors:Manoj Amrutkar, Monica Aasrum, Caroline S. Verbeke and Ivar P. Gladhaug
    Citation:BMC Cancer 2019 19:596
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  34. Content Type:Research Article

    Prenylated Rab acceptor 1 domain family, member 2 (PRAF2) is involved in the occurrence and progression of several malignant tumors. However, its potential role in esophageal squamous cell carcinoma (ESCC) is ...
    Authors:Zhaoye Qian, Bin Wei, Yu Zhou, Qiuzi Wang, Jiru Wang, Yuan Sun, Yong Gao and Xiaofei Chen
    Citation:BMC Cancer 2019 19:585
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  35. Content Type:Research Article

    In many malignancies including ovarian cancer, different angiogenic factors have been related to poor prognosis. However, data on their relations to each other or importance as a prognostic factor in ovarian c...
    Authors:Minna Sopo, Maarit Anttila, Kirsi Hämäläinen, Annukka Kivelä, Seppo Ylä-Herttuala, Veli-Matti Kosma, Leea Keski-Nisula and Hanna Sallinen
    Citation:BMC Cancer 2019 19:584
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  36. Content Type:Research Article

    By understanding Matrix Metalloprotease (MMP) dysregulation from a pan-cancer perspective, this study sheds light on the diagnostic potentials of MMPs across multiple neoplasms.
    Authors:Emily Gobin, Kayla Bagwell, John Wagner, David Mysona, Sharmila Sandirasegarane, Nathan Smith, Shan Bai, Ashok Sharma, Robert Schleifer and Jin-Xiong She
    Citation:BMC Cancer 2019 19:581
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  37. Content Type:Research Article

    Cell division cycle associated 2 (CDCA2), upregulated in lung adenocarcinoma and oral squamous cell carcinoma, may be related to some malignant diseases. Nevertheless, its role in colorectal cancer (CRC) remai...
    Authors:Yifei Feng, Wenwei Qian, Yue Zhang, Wen Peng, Jie Li, Qiou Gu, Dongjian Ji, Zhiyuan Zhang, Qingyuan Wang, Dongsheng Zhang and Yueming Sun
    Citation:BMC Cancer 2019 19:576
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  38. Content Type:Research Article

    Circular RNAs (circRNAs) that form through non-canonical backsplicing events of pre-mRNA transcripts are evolutionarily conserved and abundantly expressed across species. However, the functional relevance of c...
    Authors:Thasni Karedath, Ikhlak Ahmed, Wafa Al Ameri, Fatima M. Al-Dasim, Simeon S. Andrews, Samson Samuel, Iman K. Al-Azwani, Yasmin Ali Mohamoud, Arash Rafii and Joel A. Malek
    Citation:BMC Cancer 2019 19:565
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  39. Content Type:Research Article

    Over-expression of cyclooxygenase (COX)-2 promotes breast cancer progression by multiple mechanisms, including induction of stem-like cells (SLC). Combined gene expression and microRNA microarray analyses of e...
    Authors:Joshua Tordjman, Mousumi Majumder, Mehdi Amiri, Asma Hasan, David Hess and Peeyush K. Lala
    Citation:BMC Cancer 2019 19:561
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  40. Content Type:Research Article

    Sorting Nexin 27 (SNX27) belongs to a family of sortin nexins and possesses a unique binding domain at the C-terminus which mediates protein-protein interaction in intracellular trafficking, membrane remodelin...
    Authors:Jilei Zhang, Kendy Li, Yongguo Zhang, Rong Lu, Shaoping Wu, Jingrong Tang, Yinglin Xia and Jun Sun
    Citation:BMC Cancer 2019 19:555
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  41. Content Type:Research Article

    Programmed cell death-1 (PD-1) immune checkpoint inhibitor antibody has proven to be effective in advanced non-small cell lung cancer (NSCLC) patients positive for programmed cell death-1 ligand-1 (PD-L1). How...
    Authors:Akihito Tsunoda, Kei Morikawa, Takeo Inoue, Teruomi Miyazawa, Masahiro Hoshikawa, Masayuki Takagi and Masamichi Mineshita
    Citation:BMC Cancer 2019 19:546
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  42. Content Type:Research Article

    The multi-functional BMCC1 (BCH motif-containing molecule at the carboxyl terminal region 1)/PRUNE2 plays a clear role in suppression of tumor activity. In the patients with neuroblastoma (NB), reduced express...
    Authors:Mohammad Sazzadul Islam, Ryo Takano, Tomoki Yokochi, Jesmin Akter, Yohko Nakamura, Akira Nakagawara and Yasutoshi Tatsumi
    Citation:BMC Cancer 2019 19:542
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  43. Content Type:Research Article

    Aerobic exercise has been shown to slow tumor progression in rodents and humans, but the mechanisms behind this effect are still unclear. Here we show that aerobic exercise in the form of chronic endurance tra...
    Authors:Amit Hagar, Zemin Wang, Sachiko Koyama, Josua Aponte Serrano, Luma Melo, Stephanie Vargas, Richard Carpenter and John Foley
    Citation:BMC Cancer 2019 19:536
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  44. Content Type:Research Article

    Homeobox A5 (HOXA5), a member of the HOX family, plays an important role in tumor development and morphogenesis, although opposite effects on tumorigenesis have been observed, depending on the tissue type. In ...
    Authors:Saki Saijo, Yuki Kuwano, Shoichiro Tange, Kazuhito Rokutan and Kensei Nishida
    Citation:BMC Cancer 2019 19:532
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  46. Content Type:Research Article

    Prostate cancer displays different morphologies which, in turn, affect patient outcome. This fact prompted questions about the lineage relationship between differentiated, more treatable prostate adenocarcinom...
    Authors:Adelle D. Kanan, Eva Corey, Ricardo Z. N. Vêncio, Arjun Ishwar and Alvin Y. Liu
    Citation:BMC Cancer 2019 19:518
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  47. Content Type:Research Article

    Gastric cancer (GC) is one of the most common human cancers with the high rate of recurrence, metastasis and mortality. Aberrantly expressed microRNAs (miRNAs) are associated with invasion and metastasis in va...
    Authors:Yun Li, Xiaoli Yan, Jiajian Shi, Yun He, Jie Xu, Liying Lin, Wannan Chen, Xinjian Lin and Xu Lin
    Citation:BMC Cancer 2019 19:505
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  48. Content Type:Technical Advance

    Every biological experiment requires a choice of throughput balanced against physiological relevance. Most primary drug screens neglect critical parameters such as microenvironmental conditions, cell-cell hete...
    Authors:Vasanth S. Murali, Bo-Jui Chang, Reto Fiolka, Gaudenz Danuser, Murat Can Cobanoglu and Erik S. Welf
    Citation:BMC Cancer 2019 19:502
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  49. Content Type:Research Article

    Cancer cells modify the balance between fatty acid (FA) synthesis and uptake under metabolic stress, induced by oxygen/nutrient deprivation. These modifications were shown to alter the levels of individual tri...
    Authors:Jan Lisec, Carsten Jaeger, Rida Rashid, Rimsha Munir and Nousheen Zaidi
    Citation:BMC Cancer 2019 19:501
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  50. Content Type:Research Article

    Aberrant spliced isoforms are specifically associated with cancer progression and metastasis. The cytoplasmic adaptor CRKL (v-crk avian sarcoma virus CT10 oncogene homolog-like) is a CRK like proto-oncogene, whic...
    Authors:Qingling Song, Fengtao Yi, Yuhong Zhang, Daniel K. Jun Li, Yaxun Wei, Han Yu and Yi Zhang
    Citation:BMC Cancer 2019 19:499
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