jueves, 1 de agosto de 2019

BMC Cancer | Translational oncology

BMC Cancer | Translational oncology



BMC Cancer

Translational oncology

This section aims to consider publications which bridge laboratory basic science and applied clinical research. The section will publish studies of diagnostic and prognostic markers which may ultimately be applicable in a clinical setting with a special focus on molecular and experimental pathology. Submissions need to be REMARK compliant as established in NCI-EORTC's "Reporting Recommendations for Tumor Marker Prognostic Studies " (J Clin Oncol 23:9067, 2005) and should report biomarkers that have a clear biologic relevance to a particular tumor type.
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  1. Content Type:Research Article

    Triple Negative breast cancer (TNBC) is a poor outcome subgroup of breast cancer defined based on the absence of expression of ERα and PR and HER2 amplification. These hard to treat cancers lack targeted treat...
    Authors:Paul B. Mullan, Victoria Bingham, Paula Haddock, Gareth W. Irwin, Elaine Kay, Stephen McQuaid and Niamh E. Buckley
    Citation:BMC Cancer 2019 19:236
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  2. Content Type:Research Article

    Although sorafenib is the global standard first-line systemic treatment for unresectable hepatocellular carcinoma (HCC), it does not have reliable predictive or prognostic biomarkers. Circulating cell-free DNA...
    Authors:Chung Ryul Oh, Sun-Young Kong, Hyeon-Su Im, Hwa Jung Kim, Min Kyeong Kim, Kyong-Ah Yoon, Eun-Hae Cho, Ja-Hyun Jang, Junnam Lee, Jihoon Kang, Sook Ryun Park and Baek-Yeol Ryoo
    Citation:BMC Cancer 2019 19:292
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  3. Content Type:Research Article

    The tumor microenvironment has a critical role in regulating cancer cell behavior. Tumors with high stromal content are associated with poor patient outcome. The tumor-stroma ratio (TSR) identifies colorectal ...
    Authors:Tessa P. Sandberg, Maaike P. M. E. Stuart, Jan Oosting, Rob A. E. M. Tollenaar, Cornelis F. M. Sier and Wilma E. Mesker
    Citation:BMC Cancer 2019 19:284
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  4. Content Type:Case Report

    In clinical oncology, only a few applications have been developed using HPV as a personalized tumor marker, a lack most probably related to the limited information obtained by the classical Polymerase Chain Re...
    Authors:Alexandre Harlé, Julie Guillet, Jacques Thomas, Jessica Demange, Gilles Dolivet, Didier Peiffert, Agnès Leroux and Xavier Sastre-Garau
    Citation:BMC Cancer 2019 19:277
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  5. Content Type:Research Article

    CanAssist-Breast is an immunohistochemistry based test that predicts risk of distant recurrence in early-stage hormone receptor positive breast cancer patients within first five years of diagnosis. Immunohisto...
    Authors:Arun Kumar Attuluri, Chandra Prakash V. Serkad, Aparna Gunda, Charusheila Ramkumar, Chetana Basavaraj, Ljubomir Buturovic, Lekshmi Madhav, Nirupama Naidu, Naveen Krishnamurthy, R. Prathima, Suchita Kanaldekar and Manjiri M. Bakre
    Citation:BMC Cancer 2019 19:249
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  6. Content Type:Research Article

    Docetaxel is a widely used cytotoxic agent for treatments of various cancers. The ATP binding cassette (ABC) transporter / multidrug resistance protein (MRP) ABCC10/MRP7, involved in transporting taxanes, has ...
    Authors:Kazuki Sone, Tetsuya Oguri, Takehiro Uemura, Akira Takeuchi, Satoshi Fukuda, Osamu Takakuwa, Ken Maeno, Kensuke Fukumitsu, Yoshihiro Kanemitsu, Hirotsugu Ohkubo, Masaya Takemura, Yutaka Ito and Akio Niimi
    Citation:BMC Cancer 2019 19:246
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  7. Content Type:Research Article

    Fine-needle aspiration (FNA) is the most reliable method for diagnosing thyroid nodules; however, some features such as atypia of undetermined significance or follicular lesion of undetermined significance can...
    Authors:Masanori Teshima, Kazuya Tokita, Eijitsu Ryo, Fumihiko Matsumoto, Madoka Kondo, Yota Ikegami, Hirotaka Shinomiya, Naoki Otsuki, Nobuyoshi Hiraoka, Ken-ichi Nibu, Seiichi Yoshimoto and Taisuke Mori
    Citation:BMC Cancer 2019 19:245
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  9. Content Type:Study Protocol

    Advanced esophageal squamous cell cancer (ESCC) is frequently diagnosed in elderly patients. The impact of 2nd line chemotherapy is poorly defined. Recent data demonstrated effectiveness of checkpoint inhibito...
    Authors:Nadja M. Meindl-Beinker, Johannes Betge, Tobias Gutting, Elke Burgermeister, Sebastian Belle, Tianzuo Zhan, Nadine Schulte, Martin Maenz, Matthias P. Ebert and Nicolai Haertel
    Citation:BMC Cancer 2019 19:231
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  10. Content Type:Research Article

    Breast cancer patient-derived xenograft (BC-PDX) models represent a continuous and reproducible source of circulating tumor cells (CTCs) for studying their role in tumor biology and metastasis. We have previou...
    Authors:Arturo B. Ramirez, Raksha Bhat, Debashish Sahay, Carmine De Angelis, Hariprasad Thangavel, Sina Hedayatpour, Lacey E. Dobrolecki, Agostina Nardone, Mario Giuliano, Chandandeep Nagi, Mothaffar Rimawi, C. Kent Osborne, Michael T. Lewis, Jackie L. Stilwell, Eric P. Kaldjian, Rachel Schiff…
    Citation:BMC Cancer 2019 19:220
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  11. Content Type:Research Article

    PAM50 gene profiling assigns each cancer to a single intrinsic subtype. However, individual cancers vary in their adherence to a prototype, and due to bulk tissue sampling, some may exhibit expression patterns...
    Authors:Neeraj Kumar, Dan Zhao, Dulal Bhaumik, Amit Sethi and Peter H. Gann
    Citation:BMC Cancer 2019 19:215
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  12. Content Type:Research Article

    MicroRNA-148b (miR-148b) has been detected in various types of tumors, and is generally viewed as a tumor suppressor. Our previous study found the decreased expression of miR-148b in human non small cell lung ...
    Authors:Lin Lu, Qiyao Liu, Peipei Wang, Yong Wu, Xia Liu, Chengyin Weng, Xisheng Fang, Baoxiu Li, Xiaofei Cao, Haibo Mao, Lina Wang, Mingmei Guan, Wei Wang and Guolong Liu
    Citation:BMC Cancer 2019 19:209
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  13. Content Type:Research Article

    The role of eosinophils in cancer is not yet completely understood, but patients with eosinophilia show a trend towards longer survival in several types of cancer, including melanoma. However, eosinophil count...
    Authors:Annika Krückel, Alvaro Moreira, Waltraud Fröhlich, Gerold Schuler and Lucie Heinzerling
    Citation:BMC Cancer 2019 19:207
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  14. Content Type:Research Article

    Triple-negative breast cancer (TNBC) represents an aggressive subtype with limited therapeutic options. Experimental preclinical models that recapitulate their tumors of origin can accelerate target identifica...
    Authors:Margarite D. Matossian, Hope E. Burks, Steven Elliott, Van T. Hoang, Annie C. Bowles, Rachel A. Sabol, Bahia Wahba, Muralidharan Anbalagan, Brian Rowan, Mohamed E. Abazeed, Bruce A. Bunnell, Krzysztof Moroz, Lucio Miele, Lyndsay V. Rhodes, Steven D. Jones, Elizabeth C. Martin…
    Citation:BMC Cancer 2019 19:205
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  15. Content Type:Research Article

    Heterogeneity in bladder cancer results in variable clinical outcomes, posing challenges for clinical management of this malignancy. Recent studies suggest both tumor suppressive and oncogenic role of PPARγ in...
    Authors:Shidong Lv, Wei Wang, Hongyi Wang, Yongtong Zhu and Chengyong Lei
    Citation:BMC Cancer 2019 19:204
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  16. Content Type:Research Article

    Microtubule-associated protein Tau (MAPT) overexpression has been linked to poor prognosis and decreased response to taxane-based therapies in several cancer types, but its relevance in prostate cancer is unkn...
    Authors:Cornelia Schroeder, Jan Grell, Claudia Hube-Magg, Martina Kluth, Dagmar Lang, Ronald Simon, Doris Höflmayer, Sarah Minner, Eike Burandt, Till S. Clauditz, Franziska Büscheck, Frank Jacobsen, Hartwig Huland, Markus Graefen, Thorsten Schlomm, Guido Sauter…
    Citation:BMC Cancer 2019 19:193
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  17. Content Type:Research Article

    Previous studies have highlighted cytokine growth differentiation factor 15 (GDF-15) as a potential biomarker for digestive system tumors (DST). This study sought to assess the feasibility of using GDF-15 as a...
    Authors:Yanqiu Wang, Tao Jiang, Mingyan Jiang and Shuijing Gu
    Citation:BMC Cancer 2019 19:177
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  18. Content Type:Research Article

    The human leucine-rich, repeat-containing G protein-coupled receptor 5 (LGR5) is a stem cell marker in numerous adult tissues and is overexpressed in a large number of human carcinoma including colon cancer, brea...
    Authors:Swetlana Rot, Tom Kaune, Helge Taubert, Thomas Greither, Johanna Kotrba, Antje Güttler, Henri Wichmann, Udo Bilkenroth, Andreas Wienke, Bilal Al-Nawas, Matthias Bache, Dirk Vordermark, Claudia Wickenhauser, Daniel Bethmann, Alexander W. Eckert and Matthias Kappler
    Citation:BMC Cancer 2019 19:155
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  19. Content Type:Research Article

    Patients suffering from high risk stage II colon cancer (CC) may benefit from adjuvant onco-therapy, but additional prognostic markers are needed for better treatment stratification. We investigated the progno...
    Authors:Ann C. Eriksen, Flemming B. Sørensen, Jan Lindebjerg, Henrik Hager, René dePont Christensen, Sanne Kjær-Frifeldt and Torben F. Hansen
    Citation:BMC Cancer 2019 19:142
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  21. Content Type:Research Article

    Tumor-infiltrating lymphocytes (TILs) are described as an important immune modulator in the tumor microenvironment and are associated with breast cancer (BC) outcome. The spatial analysis of TILs and TIL subty...
    Authors:Lisa König, Fabian D. Mairinger, Oliver Hoffmann, Ann-Kathrin Bittner, Kurt W. Schmid, Rainer Kimmig, Sabine Kasimir-Bauer and Agnes Bankfalvi
    Citation:BMC Cancer 2019 19:120
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  22. Content Type:Research Article

    In recent years, PD-1/PD-L1 immune checkpoint inhibitors have improved cancer therapy in many tumor types, but no benefit of immune checkpoint therapy has been found in glioblastoma multiforme (GBM). Based on ...
    Authors:Sabrina Heynckes, Karam Daka, Pamela Franco, Annette Gaebelein, Jan Hendrik Frenking, Roberto Doria-Medina, Irina Mader, Daniel Delev, Oliver Schnell and Dieter Henrik Heiland
    Citation:BMC Cancer 2019 19:117
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  23. Content Type:Research Article

    Metastatic breast cancer (MBC) prognosis is variable, depending on several clinical and biological factors. A better prediction of a patient’s outcome could allow for a more accurate choice of treatments. The ...
    Authors:Amélie Darlix, Christophe Hirtz, Simon Thezenas, Aleksandra Maceski, Audrey Gabelle, Evelyne Lopez-Crapez, Hélène De Forges, Nelly Firmin, Séverine Guiu, William Jacot and Sylvain Lehmann
    Citation:BMC Cancer 2019 19:110
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  24. Content Type:Research Article

    MYCN amplification directly correlates with the clinical course of neuroblastoma and poor patient survival, and serves as the most critical negative prognostic marker. Although fluorescence in situ hybridizati...
    Authors:Dinesh Babu Somasundaram, Sheeja Aravindan, Zhongxin Yu, Muralidharan Jayaraman, Ngoc T. B. Tran, Shibo Li, Terence S. Herman and Natarajan Aravindan
    Citation:BMC Cancer 2019 19:106
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  25. Content Type:Research Article

    Triple negative breast cancer (TNBC) is aggressive with limited treatment options upon recurrence. Molecular discordance between primary and metastatic TNBC has been observed, but the degree of biological hete...
    Authors:Zi-Ming Zhao, Susan E. Yost, Katherine E. Hutchinson, Sierra Min Li, Yate-Ching Yuan, Javad Noorbakhsh, Zheng Liu, Charles Warden, Radia M. Johnson, Xiwei Wu, Jeffrey H. Chuang and Yuan Yuan
    Citation:BMC Cancer 2019 19:96
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  26. Content Type:Research Article

    Fascin-1, a prominent actin-bundling protein, is found to be upregulated in several human carcinomas. While it is accepted that Fascin-1 expression correlates with poor clinical outcome and decreased survival ...
    Authors:Matthias J. Arlt, Aleksandar Kuzmanov, Jess G. Snedeker, Bruno Fuchs, Unai Silvan and Adam A. Sabile
    Citation:BMC Cancer 2019 19:83
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  27. Content Type:Research Article

    Cancer is a life-threatening disease that causes every fourth death. It is often hard to determine the time point of progression. Therefore, biomarkers for cancer entities that indicate disease progression or ...
    Authors:Lisa Traeger, Ines Ellermann, Helene Wiethoff, Janina Ihbe, Inka Gallitz, Maria Eveslage, Rudolf Moritz, Edwin Herrmann, Andres Jan Schrader and Andrea U. Steinbicker
    Citation:BMC Cancer 2019 19:74
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  29. Content Type:Research Article

    The aim of this study was to evaluate the prognostic potential of urokinase-type plasminogen activator (uPA) and plasminogen activator inhibitor type 1 (PAI-1) tumor tissue levels and examine the association b...
    Authors:Marko Jevrić, Ivana Z. Matić, Ana Krivokuća, Marija Đorđić Crnogorac, Irina Besu, Ana Damjanović, Mirjana Branković-Magić, Zorka Milovanović, Dušica Gavrilović, Snezana Susnjar, Darija Kisić Tepavčević and Tatjana Stanojković
    Citation:BMC Cancer 2019 19:71
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  30. Content Type:Research Article

    Radiotherapy is an indispensable treatment modality in head and neck cancer (HNC), while radioresistance is the major cause of treatment failure. The aim of this study is to identify a prognostic molecular sig...
    Authors:Guo-Rung You, Ann-Joy Cheng, Li-Yu Lee, Yu-Chen Huang, Hsuan Liu, Yin-Ju Chen and Joseph T. Chang
    Citation:BMC Cancer 2019 19:64
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  31. Content Type:Research Article

    Poly (ADP-ribose) polymerase inhibitors (PARPi) have become the first targeted therapies available in the treatment of patients with high-grade serous ovarian cancer (HGSOC). We recently described a significan...
    Authors:Tahira Baloch, Vanessa M. López-Ozuna, Qiong Wang, Emad Matanis, Roy Kessous, Liron Kogan, Amber Yasmeen and Walter H. Gotlieb
    Citation:BMC Cancer 2019 19:44
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  32. Content Type:Research Article

    Findings remain unclear whether neutrophil-to-lymphocyte ratio (NLR) detrimentally affects advanced nasopharyngeal carcinoma (NPC) prognosis. We aim to evaluate the prognostic value of NLR in patients with NPC...
    Authors:Ji-Jin Yao, Feng-Ting Zhu, Jun Dong, Zi-Bin Liang, Le-Wei Yang, Shao-Yi Chen, Wang-Jian Zhang, Wayne R. Lawrence, Fan Zhang, Si-Yang Wang, Ying Sun and Guan-Qun Zhou
    Citation:BMC Cancer 2019 19:37
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  33. Content Type:Research Article

    Metastatic colorectal cancer (mCRC) is a major cause of death of malignant tumor and the valuable prognostic biomarker for chemotherapy is crucial in decreasing mortality. Previous studies have proved the prog...
    Authors:Jinjia Chang, Guangyi Lin, Min Ye, Duo Tong, Jing Zhao, Dan Zhu, Qihe Yu, Wen Zhang and Wenhua Li
    Citation:BMC Cancer 2019 19:15
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  34. Content Type:Research Article

    Neuroblastic tumours (NBTs) are paediatric solid tumours derived from embryonic neural crest cells which harbour their own cancer stem cells (CSC). There is evidence indicating that CSC may be responsible for ...
    Authors:Ezequiel Monferrer, Rebeca Burgos-Panadero, Maite Blanquer-Maceiras, Adela Cañete, Samuel Navarro and Rosa Noguera
    Citation:BMC Cancer 2019 19:1
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  35. Content Type:Research Article

    Adult T-cell leukemia/lymphoma (ATLL) is a lymphoproliferative disorder of HTLV-1-host interactions in infected TCD4+ cells. In this study, the HTLV-1 proviral load (PVL) and HBZ as viral elements and AKT1, BAD,
    Authors:Hanieh Tarokhian, Hossein Rahimi, Arman Mosavat, Abbas Shirdel, Houshang Rafatpanah, Mohammad Mehdi Akbarin, Alireza Bari, Samaneh Ramezani and Seyed Abdolrahim Rezaee
    Citation:BMC Cancer 2018 18:1287
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  37. Content Type:Research Article

    Regulatory T cells (Treg) suppress cytotoxic T cell anti-tumoral immune responses and thereby promote tumor progression. Prevention of intratumoral Treg accumulation by inhibition of their migration to the tum...
    Authors:Benjamin Kuehnemuth, Ignazio Piseddu, Gabriela M. Wiedemann, Michael Lauseker, Christina Kuhn, Simone Hofmann, Elisa Schmoeckel, Stefan Endres, Doris Mayr, Udo Jeschke and David Anz
    Citation:BMC Cancer 2018 18:1278
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  38. Content Type:Research Article

    Ventana ALK (D5F3) screening of anaplastic lymphoma kinase (ALK) gene rearrangement in tissue specimens has been approved by US FDA (Food and Drug Administration) to select treatment for non–small-cell lung ca...
    Authors:Hui Qin Guo, Jia Jia, Lin Lin Zhao, Huan Zhao, Cong Wang, Yue Sun, Jian Ming Ying, Lei Guo, Jian Cao and Zhi Hui Zhang
    Citation:BMC Cancer 2018 18:1277
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  39. Content Type:Research Article

    Definite prognostic clinical factors of benefit for decitabine-based induction chemotherapy in elderly patients newly diagnosed with acute myeloid leukaemia (AML) are not identified. This study was designed to...
    Authors:Jiayu Huang, Huihui Zhao, Ming Hong, Han Zhu, Yu Zhu, Yun Lian, Shan Li, Jianyong Li and Sixuan Qian
    Citation:BMC Cancer 2018 18:1269
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  40. Content Type:Technical Advance

    Clinical assays for the assessment of the human epidermal growth factor receptor-2 (HER2) status in breast cancer include immunohistochemistry (IHC) and in situ hybridization (ISH), both of which have limitati...
    Authors:David G. Hicks, Brandon Buscaglia, Hideki Goda, Loralee McMahon, Takako Natori, Bradley Turner, Armen Soukiazian, Hisatake Okada and Yasushi Nakano
    Citation:BMC Cancer 2018 18:1266
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  41. Content Type:Research Article

    Exhibiting high consistence in sequence and structure, S100 family members are interchangeable in function and they show a wide spectrum of biological processes, including proliferation, apoptosis, migration, ...
    Authors:Yang Bai, Liang-Dong Li, Jun Li and Xin Lu
    Citation:BMC Cancer 2018 18:1256
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  42. Content Type:Research Article

    Most patients with chronic myeloid leukemia (CML) treated with tyrosine kinase inhibitors (TKIs) will relapse if treatment is withdrawn, but various trials have recently demonstrated that a significant proport...
    Authors:Nuno Cerveira, Bruno Loureiro, Susana Bizarro, Cecília Correia, Lurdes Torres, Susana Lisboa, Joana Vieira, Rui Santos, Dulcineia Pereira, Cláudia Moreira, Sérgio Chacim, Nélson Domingues, Ana Espírito-Santo, Isabel Oliveira, Ilídia Moreira, Luísa Viterbo…
    Citation:BMC Cancer 2018 18:1245
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  43. Content Type:Research Article

    SSBP2, single-stranded DNA binding protein 2, is a subunit of the ssDNA-binding complex that is involved in the maintenance of genome stability. The majority of previous studies have suggested a tumor-suppress...
    Authors:Hyunsung Kim, Yeseul Kim, Yumin Chung, Rehman Abdul, Jongmin Sim, Hyein Ahn, Su-Jin Shin, Seung Sam Paik, Han Joon Kim, Kiseok Jang and Dongho Choi
    Citation:BMC Cancer 2018 18:1244
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  44. Content Type:Research Article

    The EGFR-T790M mutation is clinically detected using re-biopsy in approximately 50% of patients with acquired resistance to epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs) in advanced non-...
    Authors:Akihiro Yoshimura, Tadaaki Yamada, Naoko Okura, Takayuki Takeda, Wataru Furutani, Yutaka Kubota, Shinsuke Shiotsu, Osamu Hiranuma, Naoya Nishioka, Yusuke Chihara, Nobuyo Tamiya, Yoshiko Kaneko, Junji Uchino and Koichi Takayama
    Citation:BMC Cancer 2018 18:1241
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  45. Content Type:Research Article

    EGFR genotyping in pulmonary adenocarcinoma patients who develop pleural effusions is mostly performed using cytology or cell block slides with low sensitivity. Liquid biopsy using the supernatant of pleural e...
    Authors:Jong Sik Lee, Jae Young Hur, In Ae Kim, Hee Joung Kim, Chang Min Choi, Jae Chol Lee, Wan Seop Kim and Kye Young Lee
    Citation:BMC Cancer 2018 18:1236
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  47. Content Type:Research Article

    Prognostic factors in breast cancer are often measured on a continuous scale, but categorized for clinical decision-making. The primary aim of this study was to evaluate if accounting for continuous non-linear...
    Authors:Carina Forsare, Martin Bak, Anna-Karin Falck, Dorthe Grabau, Fredrika Killander, Per Malmström, Lisa Rydén, Olle Stål, Marie Sundqvist, Pär-Ola Bendahl and Mårten Fernö
    Citation:BMC Cancer 2018 18:1226
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  48. Content Type:Research Article

    Metastatic melanoma is one of the most aggressive forms of cancer in humans. Among its types, mucosal melanomas represent one of the most highly metastatic and aggressive forms, with a very poor prognosis. Bec...
    Authors:Zacharie Segaoula, Aline Primot, Frederic Lepretre, Benoit Hedan, Emmanuel Bouchaert, Kevin Minier, Laurent Marescaux, François Serres, Sylvie Galiègue-Zouitina, Catherine André, Bruno Quesnel, Xavier Thuru and Dominique Tierny
    Citation:BMC Cancer 2018 18:1219
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  49. Content Type:Research Article

    The aim of the present study was to investigate the association between matrix metalloproteinase-9 (MMP-9) expression with BRAF V600E mutation and clinicopathological features, in Iranian papillary thyroid can...
    Authors:Maryam Zarkesh, Azita Zadeh-Vakili, Mahdi Akbarzadeh, S. Ahmad Fanaei, Mehdi Hedayati and Fereidoun Azizi
    Citation:BMC Cancer 2018 18:1199
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  50. Content Type:Research Article

    A change of cervical cancer screening algorithms to an HPV-based screening setting is discussed in many countries, due to higher sensitivity of HPV testing compared to cytology. Reliable triage methods are, ho...
    Authors:Martina Schmitz, Kristin Eichelkraut, Dana Schmidt, Ilona Zeiser, Ziad Hilal, Zena Tettenborn, Alfred Hansel and Hans Ikenberg
    Citation:BMC Cancer 2018 18:1197
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