Lynch Syndrome Awareness
More Detailed Information on Key Tier 1 Applications - Lynch Syndrome
Facts About LS
- LS has an autosomal dominant inheritance pattern (only one copy of the mutation is needed to manifest the disease; first-degree relatives (parents, children, siblings) of an affected person have a 50% risk to inherit the mutation); other relatives (e.g., grandparents, aunts, uncles, cousins, nieces and nephews) are also at increased risk.
- Among people with LS, lifetime risk for CRC ranges from approximately 20-80%, depending upon the mutation involved, the sex of the affected individual, and the population studied;
- Mean age of onset of CRC in those with LS is approximately 45 years; and
- People with LS have an increased risk of other malignancies including those of the endometrium, ovary, urinary tract, gastric tract, small bowel, pancreas, and skin (sebaceous).