Pituitary adenylate cyclase activating peptide (PACAP) - an emerging molecule in primary headaches

Pituitary adenylate cyclase activating peptide (PACAP) - an emerging molecule in primary headaches

Edited by: Messoud Ashina

Here, we introduce the The Journal of Headache and Pain thematic series on pituitary adenylate cyclase activating peptide (PACAP) as an emerging molecule in primary headaches. Over the past decade PACAP has emerged as a key signaling in migraine and cluster headache and this thematic series summarizes the most important aspects of PACAP physiological functions from its discovery in the central nervous system to experimental studies with relevance to primary headaches.

This collection of articles has not been sponsored and articles have undergone the journal's standard peer-review process overseen by the Editor-in-Chief and Guest Editor. The Editor-in-Chief and Guest Editor declare no competing interests.

1. Content Type:Research Article

   Effectiveness of transcutaneous electrical nerve stimulation for the treatment of migraine: a meta-analysis of randomized controlled trials

   Migraine is now ranked as the second most disabling disorder worldwide reported by the Global Burden of Disease Study 2016. As a noninvasive neurostimulation technique, transcutaneous electrical nerve stimulat...

   Authors:Huimin Tao, Teng Wang, Xin Dong, Qi Guo, Huan Xu and Qi Wan

   Citation:The Journal of Headache and Pain 2018 19:42

   Published on: 29 May 2018

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2. Content Type:Review Article

   Transport of the pituitary adenylate cyclase-activating polypeptide across the blood-brain barrier: implications for migraine

   Pituitary adenylate cyclase-activating polypeptide (PACAP) is widely distributed in the nervous system and is involved in migraine pathophysiology. Understanding the function of the blood-brain barrier (BBB) i...

   Authors:Faisal Mohammad Amin and Henrik Winther Schytz

   Citation:The Journal of Headache and Pain 2018 19:35

   Published on: 21 May 2018

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3. Content Type:Editorial

   Pituitary adenylate-cyclase-activating polypeptide (PACAP): another novel target for treatment of primary headaches?

   Authors:Messoud Ashina and Paolo Martelletti

   Citation:The Journal of Headache and Pain 2018 19:33

   Published on: 8 May 2018

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4. Content Type:Review Article

   Discovery of PACAP and its receptors in the brain

   Pituitary adenylate-cyclase-activating polypeptide (PACAP) is a 27- or 38-amino acid neuropeptide, which belongs to the vasoactive intestinal polypeptide (VIP)/glucagon/secretin family. PACAP shows particularl...

   Authors:Takahiro Hirabayashi, Tomoya Nakamachi and Seiji Shioda

   Citation:The Journal of Headache and Pain 2018 19:28

   Published on: 4 April 2018

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5. Content Type:Review Article

   PACAP and migraine headache: immunomodulation of neural circuits in autonomic ganglia and brain parenchyma

   The discovery that intravenous (IV) infusions of the neuropeptide PACAP-38 (pituitary adenylyl cyclase activating peptide-38) induced delayed migraine-like headaches in a large majority of migraine patients ha...

   Authors:James A. Waschek, Serapio M. Baca and Simon Akerman

   Citation:The Journal of Headache and Pain 2018 19:23

   Published on: 13 March 2018

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6. Content Type:Review Article

   PACAP and its role in primary headaches

   Pituitary adenylate cyclase-activating peptide (PACAP) is a neuropeptide implicated in a wide range of functions, such as nociception and in primary headaches. Regarding its localization, PACAP has been observ...

   Authors:Lars Edvinsson, János Tajti, Levente Szalárdy and László Vécsei

   Citation:The Journal of Headache and Pain 2018 19:21

   Published on: 9 March 2018

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7. Content Type:Review Article

   PACAP in hypothalamic regulation of sleep and circadian rhythm: importance for headache

   The interaction between sleep and primary headaches has gained considerable interest due to their strong, bidirectional, clinical relationship. Several primary headaches demonstrate either a circadian/circannu...

   Authors:Philip R. Holland, Mads Barloese and Jan Fahrenkrug

   Citation:The Journal of Headache and Pain 2018 19:20

   Published on: 5 March 2018

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8. Content Type:Review Article

   Protective effects of PACAP in ischemia

   Pituitary adenylate cyclase activating polypeptide (PACAP) is an ubiquitous peptide involved, among others, in neurodevelopment, neuromodulation, neuroprotection, neurogenic inflammation and nociception. Prese...

   Authors:Dora Reglodi, Alexandra Vaczy, Eloísa Rubio-Beltran and Antoinette MaassenVanDenBrink

   Citation:The Journal of Headache and Pain 2018 19:19

   Published on: 2 March 2018

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9. Content Type:Review Article

   PACAP and its receptors in cranial arteries and mast cells

   In migraineurs pituitary adenylate cyclase activating peptide1–38 (PACAP1–38) is a potent migraine provoking substance and the accompanying long lasting flushing suggests degranulation of mast cells. Infusion ...

   Authors:Inger Jansen-Olesen and Sara Hougaard Pedersen

   Citation:The Journal of Headache and Pain 2018 19:16

   Published on: 20 February 2018

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10. Content Type:Review Article

    PACAP38 in human models of primary headaches

    To review the role of PACAP38 in human models of primary headaches, discuss possible mechanisms of PACAP38-induced migraine, and outline future directions.

    Authors:Håkan Ashina, Song Guo, Anne L. H. Vollesen and Messoud Ashina

    Citation:The Journal of Headache and Pain 2017 18:110

    Published on: 23 November 2017

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