Treatment Clinical Trials for Gallbladder Cancer - National Cancer Institute

Treatment Clinical Trials for Gallbladder Cancer

Clinical trials are research studies that involve people. The clinical trials on this list are for gallbladder cancer treatment. All trials on the list are supported by NCI.

NCI’s basic information about clinical trials explains the types and phases of trials and how they are carried out. Clinical trials look at new ways to prevent, detect, or treat disease. You may want to think about taking part in a clinical trial. Talk to your doctor for help in deciding if one is right for you.

Trials 1-21 of 21

Study of Pembrolizumab (MK-3475) in Participants With Advanced Solid Tumors (MK-3475-158 / KEYNOTE-158)
In this study, participants with multiple types of advanced (unresectable and / or metastatic) solid tumors that have progressed on standard of care therapy will be treated with pembrolizumab.
Location: 17 locations
Study of PEGPH20 With Cisplatin (CIS) and Gemcitabine (GEM); PEGPH20 With Atezolizumab, CIS, and GEM; and CIS and GEM Alone in Participants With Previously Untreated, Unresectable, Locally Advanced, or Metastatic Intrahepatic and Extrahepatic Cholangiocarcinoma and Gallbladder Adenocarcinoma
The study is being conducted to assess the safety and tolerability of (1) PEGPH20 in combination with CIS and GEM (PEGCISGEM), and (2) PEGPH20 in combination with CIS, GEM, and atezolizumab (PEGCISGEMATEZO) compared with (3) cisplatin and gemcitabine (CISGEM).
Location: 18 locations
Nivolumab with Gemcitabine Hydrochloride and Cisplatin or Ipilimumab as First Line Therapy in Treating Patients with Advanced Biliary Tract Cancer That Cannot Be Removed by Surgery
This randomized phase II trial studies how well nivolumab with gemcitabine hydrochloride and cisplatin or ipilimumab work as first line therapy in treating patients with biliary tract cancer that has spread to other places in the body, usually cannot be cured or controlled with treatment, and cannot be removed by surgery. Immunotherapy with monoclonal antibodies, such as nivolumab and ipilimumab, may help the body’s immune system attack the cancer, and may interfere with the ability of tumor cells to grow and spread. Drugs used in chemotherapy, such as gemcitabine hydrochloride and cisplatin, work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. Giving nivolumab with gemcitabine hydrochloride and cisplatin or ipilimumab may work better in treating patients with biliary tract cancer.
Location: 7 locations
Varlitinib in Combination With Capecitabine for Advanced or Metastatic Biliary Tract Cancer
This protocol for Varlitinib is developed for the treatment of Biliary Tract Cancer. Varlitinib (also known as ASLAN001) is a small-molecule, adenosine triphosphate competitive inhibitor of the tyrosine kinases - epidermal growth factor receptor (EGFR), human epidermal growth factor receptor (HER)2, and HER4. Varlitinib may be beneficial to subjects with cancer by simultaneous inhibition of these receptors. The purpose of this study is to determine the safety and efficacy of Varlitinib in combination with capecitabine for the treatment of Biliary Tract Cancer. Treatment groups are Varlitinib+capecitabine and Placebo + capecitabine
Location: 7 locations
Guadecitabine and Durvalumab in Treating Patients with Advanced Liver, Pancreatic, Bile Duct, or Gallbladder Cancer
This phase Ib trial studies the side effects and best dose of guadecitabine and how well it works when given together with durvalumab in treating patients with liver, pancreatic, bile duct, or gallbladder cancer that has spread to other places in the body. Guadecitabine may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth. Monoclonal antibodies, such as durvalumab, may block tumor growth in different ways by targeting certain cells. Giving guadecitabine and durvalumab may work better in treating patients with liver, pancreatic, bile duct, or gallbladder cancer.
Location: 2 locations
Study of Nivolumab in Patients with Advanced Refractory Biliary Tract Cancers
This phase II trial studies how well nivolumab works in treating patients with liver or gall bladder cancer that has spread from where it started to nearby tissue, lymph nodes, or other places in the body, has come back, has not responded to treatment, or cannot be removed by surgery. Monoclonal antibodies, such as nivolumab, may find tumor cells and help kill them.
Location: 3 locations
GL-ONC1 with or without Eculizumab in Treating Patients with Solid Organ Cancers before Surgery
This phase Ib trial studies the side effects and best dose of light-emitting oncolytic vaccinia virus GL-ONC1 (GL-ONC1) when given with or without eculizumab in treating patients with solid organ cancers before surgery. A virus called GL-ONC1, which has been changed in a certain way, may be able to kill tumor cells without damaging normal cells. Monoclonal antibodies, such as eculizumab, may interfere with the ability of tumor cells to grow and spread. Giving GL-ONC1 with or without eculizumab may work better in treating patients with solid organ cancers.
Location: 2 locations
Pembrolizumab and Sargramostim in Treating Patients with Advanced Bile Duct Cancer
This phase II trial studies how well pembrolizumab and sargramostim work in treating patients with bile duct cancer that has spread to other places in the body and usually cannot be cured or controlled with treatment. Monoclonal antibodies, such as pembrolizumab, may interfere with the ability of tumor cells to grow and spread. Colony-stimulating factors, such as sargramostim, may increase the production of blood cells and may help the immune system recover from the side effects of chemotherapy. Giving pembrolizumab and sargramostim may work better in treating patients with bile duct cancer.
Location: 2 locations
Personalized Cancer Therapy in Treating Participants with Metastatic or Unresectable Cancers
This pilot trial studies how well personalized cancer therapy works in treating participants with cancer that has spread to other places in the body or cannot be removed by surgery. Personalized cancer therapy is the practice of making decisions about what kind of treatment participants should receive based on the genetic makeup of the tumor. Genes in your body encode certain characteristics such as height, eye and hair color. Researchers believe that abnormal genes in tumors may affect how individuals respond to cancer treatments. Collecting information about tests and treatments received will help researchers describe if patients respond better when their physicians choose to treat them according to the genetic makeup of their tumor.
Location: 2 locations
Combination Therapy With NC-6004 and Gemcitabine in Advanced Solid Tumors or Non-Small Cell Lung, Biliary and Bladder Cancer
In the dose escalation phase (Part 1), this study will determine the dose-limiting toxicities (DLTs), the maximum tolerated dose (MTD) and recommended Phase 2 (RPII) dose of NC 6004 in combination with gemcitabine. In the expansion phase of the study (Part 2), study will evaluate the activity, safety, and tolerability at the RPII dose identified in Part 1 in patients with squamous NSCLC, biliary tract, and bladder cancer.
Location: 2 locations
Tumor Infiltrating Lymphocytes, Aldesleukin, and Pembrolizumab after Chemotherapy in Treating Patients with Metastatic Cancers
This phase II trial studies how well tumor infiltrating lymphocytes, aldesleukin, and pembrolizumab work after chemotherapy in treating patients with cancers that has spread to other parts of the body (metastatic). Monoclonal antibodies, such as pembrolizumab, may interfere with the ability of tumor cells to grow and spread. Aldesleukin may stimulate lymphocytes to kill tumor cells. Treating lymphocytes with aldesleukin in the laboratory may help the lymphocytes kill more tumor cells when they are put back in the body after chemotherapy.
Location: 2 locations
Oncolytic HSV-1 rRp450 in Treating Patients with Primary Liver Cancer or Liver Metastases
This phase I trial studies the side effects and best dose of oncolytic HSV-1 rRp450 in treating patients with primary liver cancer or cancer that has spread from the original tumor to the liver (liver metastases). A virus called herpes simplex virus (HSV)-1, which has been changed in a certain way, may be able to kill tumor cells without damaging normal cells.
Location: 2 locations
Gemcitabine Hydrochloride, Cisplatin, and Nivolumab in Treating Participants with Muscle-Invasive Bladder Cancer
This phase II trial studies the side effects of gemcitabine hydrochloride, cisplatin, and nivolumab and to see how well they work in treating participants with muscle-invasive bladder cancer. Drugs used in chemotherapy, such as gemcitabine hydrochloride and cisplatin, work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. Monoclonal antibodies, such as nivolumab, may interfere with the ability of tumor cells to grow and spread. Giving gemcitabine hydrochloride, cisplatin, and nivolumab may work better in treating participants with muscle-invasive bladder cancer.
Location: Icahn School of Medicine at Mount Sinai, New York, New York
Pembrolizumab, Capecitabine, and Oxaliplatin in Treating Patients with Metastatic Biliary Tract Cancer That Cannot Be Removed by Surgery
This phase II trial studies the side effects and how well pembrolizumab, capecitabine, and oxaliplatin work in treating patients with biliary tract cancer that has spread to other places in the body and cannot be removed by surgery. Monoclonal antibodies, such as pembrolizumab, may block tumor growth in different ways by targeting certain cells. Drugs used in chemotherapy, such as capecitabine and oxaliplatin, work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. Giving pembrolizumab, capecitabine, and oxaliplatin may work better in treating patients with biliary tract cancer.
Location: National Institutes of Health Clinical Center, Bethesda, Maryland
Durvalumab and Tremelimumab with and without Ablative Therapy in Treating Patients with Advanced Liver or Biliary Tract Cancer
This pilot phase I / II trial studies how well durvalumab and tremelimumab with and without ablative therapy works in treating patients with liver or bile duct cancer that cannot be removed by surgery and has not responded to previous treatment. Monoclonal antibodies, such as durvalumab and tremelimumab, may block specific proteins found on white blood cells which may strengthen the immune system and control tumor growth. Ablative therapies, such as radiofrequency ablation or cryoablation, use either heat or extreme cold to kill tumor cells. Transarterial chemoembolization uses substances to block the blood flow to the tumor. Durvalumab and tremelimumab with and without ablative therapies may help to control tumor growth.
Location: National Institutes of Health Clinical Center, Bethesda, Maryland
Copanlisib, Gemcitabine Hydrochloride, and Cisplatin in Treating Patients with Cholangiocarcinoma That Is Locally Advanced, Metastatic, or Cannot Be Removed by Surgery
This phase II trial studies how well copanlisib, gemcitabine hydrochloride, and cisplatin work in treating patients with cholangiocarcinoma that has spread to other places in the body or cannot be removed by surgery. Copanlisib may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth. Drugs used in chemotherapy, such as gemcitabine hydrochloride and cisplatin, work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. Giving copanlisib, gemcitabine hydrochloride, and cisplatin may work better in treating patients with cholangiocarcinoma.
Location: Moffitt Cancer Center, Tampa, Florida
Ramucirumab in Treating Patients with Advanced or Metastatic, Previously Treated Biliary Cancers That Cannot Be Removed by Surgery
This phase II trial studies how well ramucirumab works in treating patients with previously treated biliary cancers that have spread to other places in the body and usually cannot be cured or controlled with treatment (advanced) or have spread to other places in the body (metastatic) and cannot be removed by surgery. Monoclonal antibodies, such as ramucirumab, may block tumor growth in different ways by targeting certain cells.
Location: M D Anderson Cancer Center, Houston, Texas
Recombinant EphB4-HSA Fusion Protein with Standard Chemotherapy Regimens in Treating Patients with Advanced or Metastatic Solid Tumors
This pilot phase Ib trial studies the side effects and best dose of recombinant EphB4-HSA fusion protein when given together with standard chemotherapy regimens in treating patients with solid tumors that have spread to other places in the body and usually cannot be cured or controlled with treatment (advanced) or have spread to other places in the body (metastatic). Drugs used in chemotherapy, such as recombinant EphB4-HSA fusion protein, paclitaxel albumin-stabilized nanoparticle formulation, gemcitabine hydrochloride, docetaxel, and cisplatin, work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. It is not yet known whether standard chemotherapy regimens are more effective with recombinant ephB4-HSA fusion protein in treating advanced or metastatic solid tumors.
Location: USC / Norris Comprehensive Cancer Center, Los Angeles, California
Chemotherapy before and after Surgery in Treating Participants with Resectable Gallbladder Cancer
This phase III trial studies how well chemotherapy before and after surgery works in treating participants with gallbladder cancer that can be removed by surgery. Drugs used in chemotherapy, such as cisplatin, gemcitabine hydrochloride, and capecitabine, work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. Giving chemotherapy before and after surgery may kill more tumor cells.
Location: 3 locations
TAS-102 in Treating Advanced Biliary Tract Cancers
This phase II trial studies how well trifluridine / tipiracil hydrochloride combination agent TAS-102 (TAS-102) works in treating participants with biliary tract cancers that have spread to other places in the body. Drugs used in the chemotherapy, such as trifluridine / tipiracil hydrochloride combination agent TAS-102, work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading.
Location: 2 locations
Atezolizumab with or without Cobimetinib in Treating Patients with Metastatic Bile Duct Cancer That Cannot Be Removed by Surgery or Gallbladder Cancer
This randomized phase II trial studies how well atezolizumab with or without cobimetinib works in treating patients with bile duct cancer that has spread to other places in the body and cannot be removed by surgery or gallbladder cancer. Immunotherapy with monoclonal antibodies, such as atezolizumab, may help the body’s immune system attack the cancer, and may interfere with the ability of tumor cells to grow and spread. Cobimetinib may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth. Giving atezolizumab with cobimetinib may work better at treating patients with bile duct and gallbladder cancer.
Location: 41 locations