Bigger CRISPR- Cas12a toolbox, wider genomic coverage and higher targeting efficiencies - On Biology

Bigger CRISPR- Cas12a toolbox, wider genomic coverage and higher targeting efficiencies - On Biology

Wei Li & Fei Teng

Wei Li is a principle investigator of Institute of Zoology, Chinese Academy of Sciences. His group is now interested in studying the regulations of reproduction and regeneration, and developing new methods for genome engineering and gene therapy.

Fei Teng is a Ph.D. candidate in Institute of Zoology, Chinese Academy of Sciences. His current research pursues the application of CRISPR-Cas systems in disease modeling and development of new genome editing toolbox.

Bigger CRISPR- Cas12a toolbox, wider genomic coverage and higher targeting efficiencies

Recently published research in Genome Biology identifies several new CRISPR-Cas12a loci, a type of CRISPR-Cas system for editing mammalian genomes. Here, two of the authors of the paper, Wei Li and Fei Teng, tell us about their research and how it enhances and expands the genome editing toolbox.

Wei Li & Fei Teng 8 Feb 2019

Within only a few years, a technology referred to as “CRISPR” has not only changed the way scientists make specific changes in DNA, but also the way people can think about treating diseases. Meanwhile, CRISPR-Cas systems in the microbial kingdom have hastened the emergence of new genome engineering toolboxes.