Hot topics in headache and pain from the EHF-SAS

Hot topics in headache and pain from the EHF-SAS

Edited by: Paolo Martelletti 

This collection of articles results from the tight collaboration between the European Headache Federation (EHF) and its Official Journal, The Journal of Headache and Pain.  

​​​​​​​The educational aim of EHF, its own School of Advanced Studies (EHF-SAS), provides for nurturing talented young researchers in the headache area. Each Meeting of the EHF-SAS ends its path with the preparation of a review on special topics to be submitted for regular peer-review. EHF provides economical support for the related APCs. In such way we think that the positive loop might be maintained and attract more and more young researchers. The activity of the EHF-SAS is academically based in Sapienza University of Rome, but its mission foresees also EHF-SAS Meetings hosted by the EHF Federated Societies in their own countries.

This collection of articles has been sponsored by the EHF. Articles have undergone the journal's standard peer-review process overseen by the Editor-in-Chief. 

1. Content Type:Review Article

   CGRP and migraine from a cardiovascular point of view: what do we expect from blocking CGRP?

   Calcitonin gene-related peptide (CGRP) is a neuropeptide with a pivotal role in the pathophysiology of migraine. Blockade of CGRP is a new therapeutic target for patients with migraine. CGRP and its receptors ...

   Authors:Valentina Favoni, Luca Giani, Linda Al-Hassany, Gian Maria Asioli, Calogera Butera, Irene de Boer, Martina Guglielmetti, Chrysoula Koniari, Theodoros Mavridis, Marge Vaikjärv, Iris Verhagen, Angela Verzina, Bart Zick, Paolo Martelletti and Simona Sacco

   Citation:The Journal of Headache and Pain 2019 20:27

   Published on: 12 March 2019

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2. Content Type:Review Article

   Male and female sex hormones in primary headaches

   The three primary headaches, tension-type headache, migraine and cluster headache, occur in both genders, but all seem to have a sex-specific prevalence. These gender differences suggest that both male and fem...

   Authors:Zoë Delaruelle, Tatiana A. Ivanova, Sabrina Khan, Andrea Negro, Raffaele Ornello, Bianca Raffaelli, Alberto Terrin, Dimos D. Mitsikostas and Uwe Reuter

   Citation:The Journal of Headache and Pain 2018 19:117

   Published on: 29 November 2018

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3. Content Type:Research Article

   A PRISMA-compliant systematic review of the endpoints employed to evaluate symptomatic treatments for primary headaches

   Primary headache are prevalent and debilitating disorders. Acute pain cessation is one of the key points in their treatment. Many drugs have been studied but the design of the trials is not usually homogeneous...

   Authors:D. García-Azorin, N. Yamani, L. M. Messina, I. Peeters, M. Ferrili, D. Ovchinnikov, M. L. Speranza, V. Marini, A. Negro, S. Benemei and M. Barloese

   Citation:The Journal of Headache and Pain 2018 19:90

   Published on: 21 September 2018

   The Correction to this article has been published in The Journal of Headache and Pain 2019 20:14

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4. Content Type:Review

   Migraine and cluster headache – the common link

   Although clinically distinguishable, migraine and cluster headache share prominent features such as unilateral pain, common pharmacological triggers such glyceryl trinitrate, histamine, calcitonin gene-related...

   Authors:Anne Luise Vollesen, Silvia Benemei, Francesca Cortese, Alejandro Labastida-Ramírez, Francesca Marchese, Lanfranco Pellesi, Michele Romoli, Messoud Ashina and Christian Lampl

   Citation:The Journal of Headache and Pain 2018 19:89

   Published on: 21 September 2018

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5. Content Type:Review Article

   The association between migraine and physical exercise

   There is an unmet need of pharmacological and non-pharmacological treatment options for migraine patients. Exercise can be used in the treatment of several pain conditions, including. However, what exact role ...

   Authors:Faisal Mohammad Amin, Stavroula Aristeidou, Carlo Baraldi, Ewa K. Czapinska-Ciepiela, Daponte D. Ariadni, Davide Di Lenola, Cherilyn Fenech, Konstantinos Kampouris, Giorgos Karagiorgis, Mark Braschinsky and Mattias Linde

   Citation:The Journal of Headache and Pain 2018 19:83

   Published on: 10 September 2018

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6. Content Type:Review Article

   PACAP38 and PAC1 receptor blockade: a new target for headache?

   Pituitary adenylate cyclase activating polypeptide-38 (PACAP38) is a widely distributed neuropeptide involved in neuroprotection, neurodevelopment, nociception and inflammation. Moreover, PACAP38 is a potent i...

   Authors:Eloisa Rubio-Beltrán, Edvige Correnti, Marie Deen, Katharina Kamm, Tim Kelderman, Laura Papetti, Simone Vigneri, Antoinette MaassenVanDenBrink and Lars Edvinsson

   Citation:The Journal of Headache and Pain 2018 19:64

   Published on: 7 August 2018

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7. Content Type:Review Article

   Medication-overuse headache: a widely recognized entity amidst ongoing debate

   Medication overuse in primary headache disorders is a worldwide phenomenon and has a role in the chronification of headache disorders. The burden of disease on individuals and societies is significant due to h...

   Authors:Nicolas Vandenbussche, Domenico Laterza, Marco Lisicki, Joseph Lloyd, Chiara Lupi, Hannes Tischler, Kati Toom, Fenne Vandervorst, Simone Quintana, Koen Paemeleire and Zaza Katsarava

   Citation:The Journal of Headache and Pain 2018 19:50

   Published on: 13 July 2018

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8. Content Type:Review Article

   Headache and pregnancy: a systematic review

   This systematic review summarizes the existing data on headache and pregnancy with a scope on clinical headache phenotypes, treatment of headaches in pregnancy and effects of headache medications on the child ...

   Authors:A. Negro, Z. Delaruelle, T. A. Ivanova, S. Khan, R. Ornello, B. Raffaelli, A. Terrin, U. Reuter and D. D. Mitsikostas

   Citation:The Journal of Headache and Pain 2017 18:106

   Published on: 19 October 2017

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9. Content Type:Review Article

   Triptans and CGRP blockade – impact on the cranial vasculature

   The trigeminovascular system plays a key role in the pathophysiology of migraine. The activation of the trigeminovascular system causes release of various neurotransmitters and neuropeptides, including seroton...

   Authors:Silvia Benemei, Francesca Cortese, Alejandro Labastida-Ramírez, Francesca Marchese, Lanfranco Pellesi, Michele Romoli, Anne Luise Vollesen, Christian Lampl and Messoud Ashina

   Citation:The Journal of Headache and Pain 2017 18:103

   Published on: 10 October 2017

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10. Content Type:Review Article

    Blocking CGRP in migraine patients – a review of pros and cons

    Migraine is the most prevalent neurological disorder worldwide and it has immense socioeconomic impact. Currently, preventative treatment options for migraine include drugs developed for diseases other than mi...

    Authors:Marie Deen, Edvige Correnti, Katharina Kamm, Tim Kelderman, Laura Papetti, Eloisa Rubio-Beltrán, Simone Vigneri, Lars Edvinsson and Antoinette Maassen Van Den Brink

    Citation:The Journal of Headache and Pain 2017 18:96

    Published on: 25 September 2017

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