Epidemiology, prevention and public health
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Comparing cancer incidence, stage at diagnosis and outcomes of First Nations and all other Manitobans: a retrospective analysis
Globally, epidemiological evidence suggests cancer incidence and outcomes among Indigenous peoples are a growing concern. Although historically cancer among First Nations (FN) peoples in Canada was relatively ...BMC Cancer 2019 19:1055Prescription of pain medication among older cancer patients with and without an intellectual disability: a national register study
The longevity for people with intellectual disability (ID) has significantly increased in developed countries during the past decades. Consequently, the incidence of cancer is expected to increase in this grou...BMC Cancer 2019 19:1040Variation in the initial assessment and investigation for ovarian cancer in symptomatic women: a systematic review of international guidelines
Women with ovarian cancer can present with a variety of symptoms and signs, and an increasing range of tests are available for their investigation. A number of international guidelines provide advice for the i...BMC Cancer 2019 19:1028A matched-pair analysis on survival and response rates between German and non-German cancer patients treated at a Comprehensive Cancer Center
Research shows disparities in cancer outcomes by ethnicity or socio-economic status. Therefore, it is the aim of our study to perform a matched-pair analysis which compares the outcome of German and non-German...BMC Cancer 2019 19:1024Furosemide use and survival in patients with esophageal or gastric cancer: a population-based cohort study
Pre-clinical studies have shown that furosemide slows cancer cell growth by acting on the Na-K-2Cl transporter, particularly for gastric cancer cells. However, epidemiological studies have not investigated fur...BMC Cancer 2019 19:1017Flemish breast cancer screening programme: 15 years of key performance indicators (2002–2016)
We examined 15 years of key performance indicators (KPIs) of the population-based mammography screening programme (PMSP) in Flanders, Belgium.BMC Cancer 2019 19:1012Female sex is associated with a lower risk of bone metastases and favourable prognosis in non-sex-specific cancers
The objectives were to investigate the disparity in the prevalence of bone metastases (BM) between the sexes and to assess the effect of female sex on the development and prognosis of BM.BMC Cancer 2019 19:1001Publication statuses of clinical trials supporting FDA-approved immune checkpoint inhibitors: a meta-epidemiological investigation
The low data publication rate for Food and Drug Administration (FDA)-approved drugs, and discrepancies between FDA-submitted versus published data, remain a concern. We investigated the publication statuses of...BMC Cancer 2019 19:998Predictors of cervical cancer screening practice among HIV positive women attending adult anti-retroviral treatment clinics in Bishoftu town, Ethiopia: the application of a health belief model
Cervical cancer is a global public health problem and the second most common cancer causing morbidity and mortality in Ethiopia. Few available evidences revealed that despite distribution and severity of cervi...BMC Cancer 2019 19:989Cancer care in Brazil: structure and geographical distribution
The organisation and systematisation of health actions and services are essential to ensure patient safety and the effectiveness and efficiency of cancer care. The objective of this study was to analyse the st...BMC Cancer 2019 19:987Global patterns and trends in ovarian cancer incidence: age, period and birth cohort analysis
Ovarian cancer (OC) is the seventh most common malignancy worldwide and the most lethal gynaecological malignancy. We aimed to explore global geographical patterns and temporal trends from 1973 to 2015 for 41 ...BMC Cancer 2019 19:984Geographic distribution and risk of upper urothelial carcinomas in Croatia, 2001–2011
Strong associations exist between Balkan endemic nephropathy (BEN) and upper urothelial carcinomas (UUCs). However, the common etiology between the two remains unclear and there are no studies to date that vis...BMC Cancer 2019 19:950Tubal ligation and endometrial Cancer risk: a global systematic review and meta-analysis
Studies on relationship between tubal ligation and endometrial cancer have led to contradictory findings. In several studies, however, a reduced endometrial cancer risk was suggested following tubal ligation. ...BMC Cancer 2019 19:942Describing mortality trends for major cancer sites in 133 intermediate regions of Brazil and an ecological study of its causes
In Brazil, 211 thousand (16.14%) of all death certificates in 2016 identified cancer as the underlying cause of death, and it is expected that around 320 thousand will receive a cancer diagnosis in 2019. We ai...BMC Cancer 2019 19:940Preoperative albumin-to-fibrinogen ratio predicts severe postoperative complications in elderly gastric cancer subjects after radical laparoscopic gastrectomy
A high prevalence of postoperative complications is closely associated with a worse short- and long-term outcome. This current study aimed to investigate potential risk factors including albumin-to-fibrinogen ...BMC Cancer 2019 19:931Reproductive characteristics are associated with gene-specific promoter methylation status in breast cancer
Reproductive characteristics are well-established risk factors for breast cancer, but the underlying mechanisms are not fully resolved. We hypothesized that altered DNA methylation, measured in tumor tissue, c...BMC Cancer 2019 19:926Gingival metastasis from primary hepatocellular carcinoma: a case report and literature review of 30 cases
Gingival metastasis from primary hepatocellular cancer (HCC) is rare, highly malignant, and generally has no distinct symptoms. Not performing a biopsy can lead to misdiagnosis. This article reports an 87-year...BMC Cancer 2019 19:925Trastuzumab use in older patients with HER2-positive metastatic breast cancer: outcomes and treatment patterns in a whole-of-population Australian cohort (2003–2015)
Older patients with HER2-positive metastatic breast (HER2 + MBC) cancer are underrepresented in clinical trials. We aim to describe the treatment patterns and overall survival (OS) for older women receiving tr...BMC Cancer 2019 19:909Mapping Cancer incidence across Western Victoria: the association with age, accessibility, and socioeconomic status among men and women
Cancer is a leading burden of disease in Australia and worldwide, with incidence rates varying with age, sex and geographic location. As part of the Ageing, Chronic Disease and Injury study, we aimed to map th...BMC Cancer 2019 19:892Are social inequalities in acute myeloid leukemia survival explained by differences in treatment utilization? Results from a French longitudinal observational study among older patients
Evidences support social inequalities in cancer survival. Studies on hematological malignancies, and more specifically Acute Myeloid Leukemia (AML), are sparser. Our study assessed: 1/ the influence of patient...BMC Cancer 2019 19:883The association between fecal enterotoxigenic B. fragilis with colorectal cancer
Enterotoxigenic Bacteroides fragilis (ETBF) is an enterotoxin-producing bacterium that possibily has a role in the occurrence and progression of colorectal cancer (CRC) by modulating the mucosal immune response a...BMC Cancer 2019 19:879First-degree family history of breast cancer is associated with prostate cancer risk: a systematic review and meta-analysis
The relationship between first-degree family history of female breast cancer and prostate cancer risk in the general population remains unclear. We performed a meta-analysis to determine the association betwee...BMC Cancer 2019 19:871A cross-national perspective of migration and cancer: incidence of five major cancer types among resettlers from the former Soviet Union in Germany and ethnic Germans in Russia
Few studies compared cancer incidence among migrants both to their host countries and to their population of origin. We aimed to compare cancer incidence of ethnic Germans who migrated from the former Soviet U...BMC Cancer 2019 19:869Impact of prior malignancies on outcome of colorectal cancer; revisiting clinical trial eligibility criteria
Most clinical trials on colorectal cancer (CRC) exclude cases who have history of a prior malignancy. However, no prior research studied this history’s actual impact on the survival of CRC. In the paper, we st...BMC Cancer 2019 19:863Chronic inflammation markers are associated with risk of pancreatic cancer in the Swedish AMORIS cohort study
Nested case-control studies examining the association between serum markers of chronic inflammation, focused on three specific biomarkers (CRP, IL-8 and TNF-α), and risk of pancreatic cancer have reported no a...BMC Cancer 2019 19:858Pre-diagnostic colonoscopies reduce cancer mortality - results from linked population-based data in South Australia
To investigate the association between pre-diagnostic colonoscopy and colorectal cancer mortality in South Australia.BMC Cancer 2019 19:856Assessing a modified-AJCC TNM staging system in the New South Wales Cancer Registry, Australia
In 2017, the New South Wales Cancer Registry (NSWCR) participated in a project, supported by Cancer Australia, aiming to provide national stage data for melanoma, prostate, colorectal, breast, and lung cancers...BMC Cancer 2019 19:850Knowledge, attitudes and practices of young people in Zimbabwe on cervical cancer and HPV, current screening methods and vaccination
The rise in cervical cancer trends in the past two decades has coincided with the human immunodeficiency virus (HIV) epidemic especially in the sub-Saharan African region. Young people (15 to 24 years old) are...BMC Cancer 2019 19:845Patient preferences of chemotherapy treatment options and tolerance of chemotherapy side effects in advanced stage lung cancer
In the U.S., lung cancer accounts for 14% of cancer diagnoses and 28% of cancer deaths annually. Since no cure exists for advanced lung cancer, the main treatment goal is to prolong survival. Chemotherapy regi...BMC Cancer 2019 19:835A prospective investigation of oral contraceptive use and breast cancer mortality: findings from the Swedish women’s lifestyle and health cohort
The association between oral contraceptive (OC) use and long-term mortality remains uncertain and previous studies have reported conflicting findings. We aim to assess the long-term impact of OC use on all-cau...BMC Cancer 2019 19:807Pre-diagnosis alcohol consumption and mortality risk among black women and white women with invasive breast cancer
Alcohol consumption is associated with increased risk of breast cancer; however, its association with subsequent risk of breast cancer death is unclear.BMC Cancer 2019 19:800Use and effectiveness of pegfilgrastim prophylaxis in US clinical practice:a retrospective observational study
Febrile neutropenia (FN) is a serious complication of myelosuppressive chemotherapy. Clinical practice guidelines recommend routine prophylactic coverage with granulocyte colony-stimulating factor (G-CSF)—such...BMC Cancer 2019 19:792A 12-year trend analysis of the incidence of gastrointestinal cancers in East Azerbaijan: last updated results of an ongoing population-based cancer registry
The most recent results of Global Cancer Statistics indicated that gastrointestinal cancers, including gastric, colorectal, esophageal, and liver cancers, are among the most commonly diagnosed cancers worldwid...BMC Cancer 2019 19:782Comparative effectiveness of primary tumor resection in patients with stage III pancreatic adenocarcinoma
Previous studies comparing primary tumor resection (PTR) to palliative treatment for advanced-stage pancreatic ductal adenocarcinoma (PDA) were limited by strong selection bias. We used multiple methods to con...BMC Cancer 2019 19:761Prediction of advanced colonic neoplasm in symptomatic patients: a scoring system to prioritize colonoscopy (COLONOFIT study)
Fast-track colonoscopy to detect patients with colorectal cancer based on high-risk symptoms is associated with low sensitivity and specificity. The aim was to derive a predictive score of advanced colonic neo...BMC Cancer 2019 19:734Statin use and the risk of ovarian and endometrial cancers: a meta-analysis
The relationship between statin use and the risk of ovarian or endometrial cancer remains controversial. Here, we investigated the relationship between statin use and the risk of ovarian and endometrial cancers.BMC Cancer 2019 19:730Overweight and obesity as predictors of early mortality in Mexican children with acute lymphoblastic leukemia: a multicenter cohort study
Mexico City has one of the highest incidences and mortality rates of acute lymphoblastic leukemia (ALL) in the world and a high frequency of early relapses (17%) and early mortality (15%). Otherwise, childhood...BMC Cancer 2019 19:708A clinical model to predict the risk of synchronous bone metastasis in newly diagnosed colorectal cancer: a population-based study
The early detection of synchronous bone metastasis (BM) in newly diagnosed colorectal cancer (CRC) affects its initial management and prognosis. A clinical model to individually predict the risk of developing ...BMC Cancer 2019 19:704Sexual dimorphism in the incidence of human cancers
Sex differences in the incidences of cancers become a critical issue in both cancer research and the development of precision medicine. However, details in these differences have not been well reported. We pro...BMC Cancer 2019 19:684External validation of molecular subtype classifications of colorectal cancer based on microsatellite instability, CIMP, BRAF and KRAS
Competing molecular classification systems have been proposed to complement the TNM staging system for a better prediction of survival in colorectal cancer (CRC). However, validation studies are so far lacking...BMC Cancer 2019 19:681A nomogram for determining the disease-specific survival in Ewing sarcoma: a population study
We aimed to develop and validate a nomogram for predicting the disease-specific survival of Ewing sarcoma (ES) patients.BMC Cancer 2019 19:667Preliminary evidence for physical activity following pelvic exenteration: a pilot longitudinal cohort study
The physical activity (PA) level of patients undergoing major cancer surgery remains unclear. This pilot study aimed to: (i) Compare preoperative PA level between patients undergoing major cancer surgery and t...BMC Cancer 2019 19:661Adherence to quality breast cancer survivorship care in four Canadian provinces: a CanIMPACT retrospective cohort study
In order to maximize later health, there are established components and guidelines for quality follow-up care of breast cancer survivors. However, adherence to quality follow-up in Canada may not be optimal, a...BMC Cancer 2019 19:659Impact of genetic mutations and nutritional status on the survival of patients with colorectal cancer
The prognosis of colorectal cancer (CRC) patients can be influenced by genetic mutations and nutritional status. The relationship between these variables is unclear. The objective of the study was to verify th...BMC Cancer 2019 19:644Incidence of thyroid cancer in Puerto Rico and the US by racial/ethnic group, 2011–2015
Puerto Rico has the highest incidence rate of thyroid cancer (TC) in the Americas and the third highest rate worldwide. The purpose of this study was to compare the burden of TC between the population of PR an...BMC Cancer 2019 19:637Predictors of mammographic density among women with a strong family history of breast cancer
Mammographic density is one of the strongest risk factors for breast cancer. In the general population, mammographic density can be modified by various exposures; whether this is true for women a strong family...BMC Cancer 2019 19:631Chronic inflammatory diseases, anti-inflammatory medications and risk of prostate cancer: a population-based case-control study
Whether chronic inflammation increases prostate cancer risk remains unclear. This study investigated whether chronic inflammatory diseases (CID) or anti-inflammatory medication use (AIM) were associated with p...BMC Cancer 2019 19:612Cancer stigma and cancer screening attendance: a population based survey in England
Cancer-related stigma attracts considerable research interest, but few studies have examined stigmatisation in the healthy population. Qualitative studies suggest that stigma can discourage people from attendi...BMC Cancer 2019 19:566Evidence on the prevalence, incidence, mortality and trends of human papilloma virus-associated cancers in sub-Saharan Africa: systematic scoping review
Human papilloma virus (HPV) associated cervical cancer remains a global concern particular, in Sub-Saharan Africa (SSA) where the impact is felt most. Evidence show that many other cancers such as vaginal, ana...BMC Cancer 2019 19:563Real-world treatment patterns and adverse events in metastatic renal cell carcinoma from a large US claims database
Vascular endothelial growth factor (VEGF), tyrosine kinase (TK) and mechanistic target of rapamycin kinase (mTOR) inhibitors are common first-line (1 L) treatments for metastatic renal cell carcinoma (mRCC). D...BMC Cancer 2019 19:548
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