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| Immunology | |
| The latest immunology news from News Medical | |
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| What are you missing with MMR by IHC testing alone?
IHC can miss up to 10% of dMMR tumor samples. Current guidelines recommend co-testing tumor samples using both MSI by PCR and MMR by IHC, decreasing the number of mischaracterized tumor samples to less than 1%
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| Scientists attempt to cure HIV using CRISPR, with varying results Scientists have used the gene-editing technology CRISPR in an attempt to cure a person infected with HIV, with some success. The attempt was successful, but only to a certain extent ̶ the edited cells have survived in the man’s body for more than a year and no side effects were detected. However, there were not enough cells to significantly reduce the amount of HIV in his blood, so the effort fell short of being a cure for the illness. | |
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| Juvenile immune arthritis – new treatments wanted Juvenile immune arthritis (JIA) is a severely undertreated condition, and new medications are badly needed to relieve the signs and symptoms of the illness, according to a new study presented at the 2019 ACR/ARP Annual Meeting. | |
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| Scientists use CAR-T cells to reverse cardiac fibrosis Scientists at the University of Pennsylvania’s Abramson Cancer Center have used CAR-T cells to treat cardiac fibrosis, a key part of heart disease and cardiac arrest. The novel study, which was recently published in Nature, explains how the T cell therapy has been successfully implemented to target and destroy the scar tissue that ultimately leads to heart failure. | |
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| Vaccination against HIV can be counterproductive if it triggers the wrong type of immune response A discovery could help immunologists design vaccines that are more effective in protecting against HIV infection. Several non-human primate studies looking at HIV's relative – SIV – provided evidence that creating too many soft targets can weaken vaccination that would have otherwise protected against infection. | |
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