γ-Secretase modulators exhibit selectivity for modulation of APP cleavage but inverse γ-secretase modulators do not | Alzheimer's Research & Therapy | Full Text

γ-Secretase modulators exhibit selectivity for modulation of APP cleavage but inverse γ-secretase modulators do not | Alzheimer's Research & Therapy | Full Text

γ-Secretase modulators exhibit selectivity for modulation of APP cleavage but inverse γ-secretase modulators do not

γ-Secretase is a multiprotein protease that cleaves amyloid protein precursor (APP) and other type I transmembrane proteins. It has two catalytic subunits, presenilins 1 and 2 (PS1 and 2). In our previous repo...

Authors:Christian B. Lessard, Edgardo Rodriguez, Thomas B. Ladd, Lisa M. Minter, Barbara A. Osborne, Lucio Miele, Todd E. Golde and Yong Ran

Citation:Alzheimer's Research & Therapy 2020 12:61

Content type:Research

Published on: 19 May 2020

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