The Journal of Headache and Pain | Articles

The Journal of Headache and Pain | Articles

1. An unexpected and suspended time

   Authors:Paolo Martelletti

   Citation:The Journal of Headache and Pain 2020 21:36

   Content type:Editorial

   Published on: 22 April 2020

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2. Neurotransmitter and tryptophan metabolite concentration changes in the complete Freund’s adjuvant model of orofacial pain

   The neurochemical background of the evolution of headache disorders, still remains partially undiscovered. Accordingly, our aim was to further explore the neurochemical profile of Complete Freund’s adjuvant (C...

   Authors:Edina K. Cseh, Gábor Veres, Tamás Körtési, Helga Polyák, Nikolett Nánási, János Tajti, Árpád Párdutz, Péter Klivényi, László Vécsei and Dénes Zádori

   Citation:The Journal of Headache and Pain 2020 21:35

   Content type:Research article

   Published on: 21 April 2020

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3. Short-latency afferent inhibition and somato-sensory evoked potentials during the migraine cycle: surrogate markers of a cycling cholinergic thalamo-cortical drive?

   Short-latency afferent inhibition (SAI) consists of motor cortex inhibition induced by sensory afferents and depends on the excitatory effect of cholinergic thalamocortical projections on inhibitory GABAergic ...

   Authors:Gianluca Coppola, Davide Di Lenola, Chiara Abagnale, Fabio Ferrandes, Gabriele Sebastianelli, Francesco Casillo, Cherubino Di Lorenzo, Mariano Serrao, Maurizio Evangelista, Jean Schoenen and Francesco Pierelli

   Citation:The Journal of Headache and Pain 2020 21:34

   Content type:Research article

   Published on: 16 April 2020

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4. Clinical correlates of insomnia in patients with persistent post-traumatic headache compared with migraine

   Close associations between insomnia with other clinical factors have been identified in migraine, but there have been few studies investigating associations between insomnia and clinical factors in patients wi...

   Authors:Soo-Kyoung Kim, Catherine D. Chong, Gina Dumkrieger, Katherine Ross, Visar Berisha and Todd J. Schwedt

   Citation:The Journal of Headache and Pain 2020 21:33

   Content type:Research article

   Published on: 15 April 2020

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5. Real-life data on the efficacy and safety of erenumab in the Abruzzo region, central Italy

   We aimed to assess the efficacy and safety of erenumab, a fully human monoclonal antibody inhibiting the calcitonin gene-related peptide receptor (CGRPr), for the prevention of migraine in a real-life setting.

   Authors:Raffaele Ornello, Alfonsina Casalena, Ilaria Frattale, Amleto Gabriele, Giannapia Affaitati, Maria Adele Giamberardino, Maurizio Assetta, Maurizio Maddestra, Fabio Marzoli, Stefano Viola, Davide Cerone, Carmine Marini, Francesca Pistoia and Simona Sacco

   Citation:The Journal of Headache and Pain 2020 21:32

   Content type:Research article

   Published on: 7 April 2020

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6. Cognitive aging in migraine sufferers is associated with more subjective complaints but similar age-related decline: a 5-year longitudinal study

   The effect of headache on cognitive performance is controversial, due to conflicting results obtained from studies in clinical or population settings. We aimed to understand if migraine and other headaches mod...

   Authors:Isabel Pavão Martins, Carolina Maruta, Pedro Nacimento Alves, Clara Loureiro, Joana Morgado, Joana Tavares and Raquel Gil-Gouveia

   Citation:The Journal of Headache and Pain 2020 21:31

   Content type:Research article

   Published on: 7 April 2020

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7. Phase dependent hypothalamic activation following trigeminal input in cluster headache

   Task-free imaging approaches using PET have shown the posterior hypothalamus to be specifically activated during but not outside cluster headache attacks. Evidence from task related functional imaging approach...

   Authors:Laura H. Schulte, Ame Abdu Haji and Arne May

   Citation:The Journal of Headache and Pain 2020 21:30

   Content type:Research article

   Published on: 30 March 2020

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8. The cerebellum is associated with 2-year prognosis in patients with high-frequency migraine

   The increase of headache frequency is associated with higher headache related disability and lower quality of life in patients with migraine. However, the pathophysiology of migraine progression, persistence, ...

   Authors:Hung-Yu Liu, Pei-Lin Lee, Kun-Hsien Chou, Kuan-Lin Lai, Yen-Feng Wang, Shih-Pin Chen, Wei-Ta Chen and Shuu-Jiun Wang

   Citation:The Journal of Headache and Pain 2020 21:29

   Content type:Research article

   Published on: 18 March 2020

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9. European Headache Federation recommendations for neurologists managing giant cell arteritis

   Giant cell arteritis (GCA) remains a medical emergency because of the risk of sudden irreversible sight loss and rarely stroke along with other complications. Because headache is one of the cardinal symptoms o...

   Authors:S. P. Mollan, K. Paemeleire, J. Versijpt, R. Luqmani and A. J. Sinclair

   Citation:The Journal of Headache and Pain 2020 21:28

   Content type:Consensus article

   Published on: 17 March 2020

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10. Migraine, headache, and mortality in women: a cohort study

    Migraine carries a high global burden, disproportionately affects women, and has been implicated as a risk factor for cardiovascular disease. Migraine with aura has been consistently associated with increased ...

    Authors:Jessica L. Rohmann, Pamela M. Rist, Julie E. Buring and Tobias Kurth

    Citation:The Journal of Headache and Pain 2020 21:27

    Content type:Research article

    Published on: 17 March 2020

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11. Understanding side-effects of anti-CGRP and anti-CGRP receptor antibodies

    Authors:Kristian Agmund Haanes, Lars Edvinsson and Anette Sams

    Citation:The Journal of Headache and Pain 2020 21:26

    Content type:Letter to the Editor

    Published on: 16 March 2020

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12. Rapid referral for headache management from emergency department to headache centre: four years data

    Headache is one of the most common reason for medical consultation to emergency department (ED). The inappropriate use of ED for non-emergency conditions is a problem in terms of overcrowding of emergency faci...

    Authors:Andrea Negro, Valerio Spuntarelli, Paolo Sciattella and Paolo Martelletti

    Citation:The Journal of Headache and Pain 2020 21:25

    Content type:Research article

    Published on: 14 March 2020

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13. Time trends of major headache diagnoses and predictive factors. Data from three Nord-Trøndelag health surveys

    The primary aim of this study was to investigate time trends of major headache diagnoses using cross-sectional data from two population-based health surveys. In addition, we aimed to perform a longitudinal ass...

    Authors:Knut Hagen, Lars Jacob Stovner and John-Anker Zwart

    Citation:The Journal of Headache and Pain 2020 21:24

    Content type:Research article

    Published on: 11 March 2020

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14. Comorbid and co-occurring conditions in migraine and associated risk of increasing headache pain intensity and headache frequency: results of the migraine in America symptoms and treatment (MAST) study

    Migraine has many presumed comorbidities which have rarely been compared between samples with and without migraine. Examining the association between headache pain intensity and monthly headache day (MHD) freq...

    Authors:Dawn C. Buse, Michael L. Reed, Kristina M. Fanning, Ryan Bostic, David W. Dodick, Todd J. Schwedt, Sagar Munjal, Preeti Singh and Richard B. Lipton

    Citation:The Journal of Headache and Pain 2020 21:23

    Content type:Research article

    Published on: 2 March 2020

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15. The effects of vitamin D supplementation on interictal serum levels of calcitonin gene-related peptide (CGRP) in episodic migraine patients: post hoc analysis of a randomized double-blind placebo-controlled trial

    Emerging evidence showed promising effects of vitamin D on headaches characteristics. Thus, it seems there is still a need for more researches to clarify the mechanisms by which this vitamin exerts anti-migrai...

    Authors:Zeinab Ghorbani, Pegah Rafiee, Akbar Fotouhi, Samane Haghighi, Reyhaneh Rasekh Magham, Zeynab Sadat Ahmadi, Mahmoud Djalali, Mahnaz Zareei, Soodeh Razeghi Jahromi, Sahar Shahemi, Maryam Mahmoudi and Mansoureh Togha

    Citation:The Journal of Headache and Pain 2020 21:22

    Content type:Research article

    Published on: 24 February 2020

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16. Trajectory of migraine-related disability following long-term treatment with lasmiditan: results of the GLADIATOR study

    Migraine is recognized as the second leading cause of disability globally. Lasmiditan is a novel, selective serotonin 5-HT1F receptor agonist developed for acute treatment of migraine. Here we analyzed effects of...

    Authors:Richard B. Lipton, Louise Lombard, Dustin D. Ruff, John H. Krege, Li Shen Loo, Andrew Buchanan, Thomas E. Melby and Dawn C. Buse

    Citation:The Journal of Headache and Pain 2020 21:20

    Content type:Research article

    Published on: 24 February 2020

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17. Investigation of sumatriptan and ketorolac trometamol in the human experimental model of headache

    Pituitary adenylate cyclase-activating polypeptide-38 (PACAP38) induces headache in healthy volunteers but the precise mechanisms by which PACAP38 leads to headache are unclear. We investigated the headache pr...

    Authors:Hashmat Ghanizada, Mohammad Al-Mahdi Al-Karagholi, Nanna Arngrim, Mette Mørch-Rasmussen, Matias Metcalf-Clausen, Henrik Bo Wiberg Larsson, Faisal Mohammad Amin and Messoud Ashina

    Citation:The Journal of Headache and Pain 2020 21:19

    Content type:Research article

    Published on: 24 February 2020

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18. Altered lateral geniculate nucleus functional connectivity in migraine without aura: a resting-state functional MRI study

    To investigate the structural and functional connectivity changes of lateral geniculate nucleus (LGN) and their relationships with clinical characteristics in patients without aura.

    Authors:Di Zhang, Xiaobin Huang, Wen Su, Yuchen Chen, Peng Wang, Cunnan Mao, Zhengfei Miao, Chunmei Liu, Chenjie Xu, Xindao Yin and Xinying Wu

    Citation:The Journal of Headache and Pain 2020 21:17

    Content type:Research article

    Published on: 17 February 2020

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19. Fluctuations in local and widespread mechanical sensitivity throughout the migraine cycle: a prospective longitudinal study

    People with migraine have localised (i.e., cephalic) mechanical sensitivity. There is uncertainty regarding widespread (i.e., extra-cephalic) mechanical sensitivity and variations in mechanical sensitivity thr...

    Authors:Gwendolyne G. M. Scholten-Peeters, Michel W. Coppieters, Tom S. C. Durge and René F. Castien

    Citation:The Journal of Headache and Pain 2020 21:16

    Content type:Research article

    Published on: 14 February 2020

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20. Gut-brain Axis and migraine headache: a comprehensive review

    The terminology “gut-brain axis “points out a bidirectional relationship between the GI system and the central nervous system (CNS). To date, several researches have shown that migraine is associated with some...

    Authors:Mahsa Arzani, Soodeh Razeghi Jahromi, Zeinab Ghorbani, Fahimeh Vahabizad, Paolo Martelletti, Amir Ghaemi, Simona Sacco and Mansoureh Togha

    Citation:The Journal of Headache and Pain 2020 21:15

    Content type:Review article

    Published on: 13 February 2020

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21. Different doses of galcanezumab versus placebo in patients with migraine and cluster headache: a meta-analysis of randomized controlled trials

    Galcanezumab is a novel monoclonal antibody that target to calcitonin gene-related peptide (CGRP). It has been tested for the preventive treatment of migraine and episodic cluster headache by multiple randomiz...

    Authors:Yanbo Yang, Zilan Wang, Bixi Gao, He Xuan, Yun Zhu, Zhouqing Chen and Zhong Wang

    Citation:The Journal of Headache and Pain 2020 21:14

    Content type:Research article

    Published on: 11 February 2020

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22. Genetic variants in migraine: a field synopsis and systematic re-analysis of meta-analyses

    Numerous genetic variants from meta-analyses of observational studies and GWAS were reported to be associated with migraine susceptibility. However, due to the random errors in meta-analyses, the noteworthines...

    Authors:Yating Zhao, Ruixia Zhu, Tongling Xiao and Xu Liu

    Citation:The Journal of Headache and Pain 2020 21:13

    Content type:Research article

    Published on: 11 February 2020

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23. Exploring naturally occurring clinical subgroups of post-traumatic headache

    To explore naturally occurring clinical subgroups of post-traumatic headache.

    Authors:T. L. H. Chan and Y. W. Woldeamanuel

    Citation:The Journal of Headache and Pain 2020 21:12

    Content type:Research article

    Published on: 7 February 2020

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24. The prevalence of primary headache disorders in Saudi Arabia: a cross-sectional population-based study

    The large geographical gaps in our knowledge of the prevalence and burden of headache disorders include most of Eastern Mediterranean Region (EMR). Following a nationwide population-based study in Pakistan, we...

    Authors:Mohammed Al Jumah, Ali M. Al Khathaami, Suleman Kojan, Mohamed Hussain, Hallie Thomas and Timothy J. Steiner

    Citation:The Journal of Headache and Pain 2020 21:11

    Content type:Research article

    Published on: 7 February 2020

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25. The distribution of oxytocin and the oxytocin receptor in rat brain: relation to regions active in migraine

    Recent work, both clinical and experimental, suggests that the hypothalamic hormone oxytocin (OT) and its receptor (OTR) may be involved in migraine pathophysiology.

    Authors:Karin Warfvinge, Diana Krause and Lars Edvinsson

    Citation:The Journal of Headache and Pain 2020 21:10

    Content type:Research article

    Published on: 7 February 2020

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26. Excess abdominal fat is associated with cutaneous allodynia in individuals with migraine: a prospective cohort study

    To investigate the specific relationship between cutaneous allodynia (CA) and the percentages of body fat (BF) and abdominal fat in migraineurs. Additionally, we compared serum levels of inflammatory biomarker...

    Authors:Ane Mínguez-Olaondo, Iván Martínez-Valbuena, Sonia Romero, Gema Frühbeck, María Rosario Luquin, Eduardo Martínez-Vila and Pablo Irimia

    Citation:The Journal of Headache and Pain 2020 21:9

    Content type:Research article

    Published on: 4 February 2020

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27. Burden of migraine in Finland: multimorbidity and phenotypic disease networks in occupational healthcare

    Migraine is a complex neurological disorder with high co-existing morbidity burden. The aim of our study was to examine the overall morbidity and phenotypic diseasome for migraine among people of working age u...

    Authors:Minna A. Korolainen, Samuli Tuominen, Samu Kurki, Mariann I. Lassenius, Iiro Toppila, Timo Purmonen, Jaana Santaholma and Markku Nissilä

    Citation:The Journal of Headache and Pain 2020 21:8

    Content type:Research article

    Published on: 31 January 2020

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28. Two decades, a new editorial stylistic feature

    Authors:Paolo Martelletti

    Citation:The Journal of Headache and Pain 2020 21:7

    Content type:Editorial

    Published on: 24 January 2020

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29. Dural arteriovenous fistulas and headache features: an observational study

    Dural arteriovenous fistulas are intracranial vascular malformations, fed by dural arteries and draining venous sinuses or meningeal veins. Clinical course varies widely and ranges from benign with spontaneous...

    Authors:Ilenia Corbelli, Francesca De Maria, Paolo Eusebi, Michele Romoli, Gabriela Cardaioli, Mohammed Hamam, Piero Floridi, Letizia Maria Cupini, Paola Sarchielli and Paolo Calabresi

    Citation:The Journal of Headache and Pain 2020 21:6

    Content type:Research article

    Published on: 16 January 2020

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30. Prevalence and risk factors associated with headache amongst medical staff in South China

    A previous study by our team reported the prevalence of primary headache disorders and factors associated with headache among nurses in three hospitals in North China. The aim of this cross-sectional survey wa...

    Authors:Wei Xie, Ruibing Li, Mianwang He, Fang Cui, Tingting Sun, Jianmei Xiong, Dengfa Zhao, Weinan Na, Ruozhuo Liu and Shengyuan Yu

    Citation:The Journal of Headache and Pain 2020 21:5

    Content type:Research article

    Published on: 14 January 2020

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31. Microglia P2X4R-BDNF signalling contributes to central sensitization in a recurrent nitroglycerin-induced chronic migraine model

    According to our previous study, microglia P2X4 receptors (P2X4Rs) play a pivotal role in the central sensitization of chronic migraine (CM). However, the molecular mechanism that underlies the crosstalk betwe...

    Authors:Ting Long, Wei He, Qi Pan, Shanshan Zhang, Dunke Zhang, Guangcheng Qin, Lixue Chen and Jiying Zhou

    Citation:The Journal of Headache and Pain 2020 21:4

    Content type:Research article

    Published on: 14 January 2020

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32. The epidemiology of headaches among patients with epilepsy: a systematic review and meta-analysis

    Headache is the symptom of pain in the face, head or neck that causes disability in most people with medical and neurological disorders. It frequently co-occurs with most chronic diseases such as epilepsy and ...

    Authors:Bereket Duko, Mohammed Ayalew and Alemayehu Toma

    Citation:The Journal of Headache and Pain 2020 21:3

    Content type:Research article

    Published on: 10 January 2020

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33. ICHD-3 is significantly more specific than ICHD-3 beta for diagnosis of migraine with aura and with typical aura

    In the emergency room, distinguishing between a migraine with aura and a transient ischemic attack (TIA) is often not straightforward and mistakes can be harmful to both the patient and to society. To account ...

    Authors:Carl H. Göbel, Sarah C. Karstedt, Thomas F. Münte, Hartmut Göbel, Sebastian Wolfrum, Elena R. Lebedeva, Jes Olesen and Georg Royl

    Citation:The Journal of Headache and Pain 2020 21:2

    Content type:Research article

    Published on: 7 January 2020

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