herenciageneticayenfermedad: Science Update: Testosterone protects males from miscarriage caused by genomic instability and inflammation | NICHD - Eunice Kennedy Shriver National Institute of Child Health and Human Development

lunes, 4 de marzo de 2019

Science Update: Testosterone protects males from miscarriage caused by genomic instability and inflammation | NICHD - Eunice Kennedy Shriver National Institute of Child Health and Human Development

Female mouse embryos susceptible to certain stressors, according to NICHD-funded study

Wednesday, February 20, 2019

Chromosomes are colored blue, with the chromosome in the center of the image colored in shades of yellow, pink, purple, and blue.

3D image of chromosomes.

The anti-inflammatory properties of testosterone appear to protect male mouse embryos from certain types of DNA damage and inflammation that are fatal to female mouse embryos, according to a recent NIH-supported study. Treating pregnant mice with testosterone or ibuprofen improved the survival of female embryos with DNA damage and resulted in normal gender ratios among the mouse pups.

While the results are early and need to be replicated in people, the study offers clues on the factors involved in pregnancy loss. The work was funded by NIH’s Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) and appears in the journal Nature.