Genomics & Health Impact Scan Database|Weekly Scan|PHGKB
Publication Date: Jun 8, 2017
About the Genomics & Health Impact Weekly Scan
This weekly update features emerging roles of human genomics, testing and interventions in a wide variety of noncommunicable diseases across the life span, including, birth defects, newborn screening, reproductive health, childhood diseases, cancer, chronic diseases, pharmacogenomics, family health history, guidelines and recommendations. The weekly sweep also includes news, reviews, commentaries, tools and databases.
Human Genomics across the Lifespan
Birth Defects and Child Health
Cancer
- Distinct implications of different BRCA mutations: efficacy of cytotoxic chemotherapy, PARP inhibition and clinical outcome in ovarian cancer.
Hollis Robert L et al. OncoTargets and therapy 2017 102539-2551
- Epidermal growth factor receptor and anaplastic lymphoma kinase testing and mutation prevalence in patients with advanced non-small cell lung cancer in Switzerland: A comprehensive evaluation of real world practices.
Ess S M et al. European journal of cancer care 2017 May
- Improving Health and Quality of Life After Cancer
- PARP inhibitors in ovarian cancer: evidence, experience and clinical potential.
Evans Tarra et al. Therapeutic advances in medical oncology 2017 Apr 9(4) 253-267
- Prognostic Importance of C-KIT Mutations in Core Binding Factor Acute Myeloid Leukemia: A Systematic Review.
Ayatollahi Hossein et al. Hematology/oncology and stem cell therapy 2017 Mar 10(1) 1-7
- Poly(adenosine diphosphate-ribose) polymerase as therapeutic target: lessons learned from its inhibitors.
Cseh Anna Mária et al. Oncotarget 2017 Apr
- Precision or imprecision medicine?
L Hutchinson et al, Nat Rev Clin Oncol 2016
- Could a Blood Test Detect Early-Stage Cancers?
M Tontonoz, ASCO, June 2017
- New Drug Shows Durable Efficacy Across Diverse Pediatric and Adult Cancers-Larotrectinib Targets Rare Genetic Abnormality, TRK Fusions
ASCO, June 3, 2017
- Office of Cancer Survivorship
- Phase III Trial of PARP Inhibitor Shows First Evidence of Improved Outcomes in Breast Cancer
Memorial Sloan Kettering, ASCO, June 4, 2017
- 'Liquid Biopsy Passes Early Test in Quest to Find Cancer in Blood
Fortune, June 3, 2017
- How and When to Implement Precision Oncology How and When to Implement Precision Oncology How and when to implement precision oncology
LD Nadauld et al, ASCO 2017 annual meeting
- Game of chance: Are most cancers linked to nothing more than bad luck?
M Knight, June 1, 2017, Genetic Literacy Project
- Childhood Cancer Genomics (PDQ®) Health Professional Version
- Clinical utility of gene-expression signatures in early stage breast cancer.
Kwa Maryann et al. Nature reviews. Clinical oncology 2017 May
- Identification of Genomic Somatic Variants in Cancer: From Discovery to Actionability.
Fawcett G L et al. Advances in clinical chemistry 78123-162
- Sharing Clinical and Genomic Data on Cancer - The Need for Global Solutions.
et al. The New England journal of medicine 2017 376(21) 2006-2009
- Recommendations for Childhood Cancer Screening and Surveillance in DNA Repair Disorders.
Walsh Michael F et al. Clinical cancer research : an official journal of the American Association for Cancer Research 2017 Jun 23(11) e23-e31
- A Rapid and Sensitive Next-Generation Sequencing Method to Detect RB1 Mutations Improves Care for Retinoblastoma Patients and Their Families.
Li Wenhui L et al. The Journal of molecular diagnostics : JMD 2016 Jul 18(4) 480-93
- CONNECT registry shows only 9 percent compliance with genetic testing guidelines for AML
Science Mag, June 5, 2017
- Routine genomic testing is feasible, but only a subset of patients benefit
Science Mag, June 5, 2017
- Routine Genomic Testing in Cancer Patients May Be Feasible
Cancer Network, ASCO, June 3, 2017
Genomics in Practice
- A Proposed Genomic Literacy, Education, and Engagement (GLEE) Initiative
NHGRI, June 6, 2017
- Precision Public Health: Introduction Sources for all disciplines charged with ensuring the health of whole populations
University of Florida, 2017
- Introducing "Genomics and Precision Health".
Feero W Gregory et al. JAMA 2017 317(18) 1842-1843
- No Shortcuts on the Long Road to Evidence-Based Genomic Medicine.
Khoury Muin J et al. JAMA 2017 Jun
- Data Sharing Statements for Clinical Trials: A Requirement of the International Committee of Medical Journal Editors.
Taichman Darren B et al. JAMA 2017 Jun
- Beta Testing Begins for NIHs All of Us Research Program
- Personalized medicine in Europe: not yet personal enough?
Di Paolo Antonello et al. BMC health services research 2017 Apr 17(1) 289
- Do It Youself Genetic Tests Create Challenge For Doctors,
CBS SF Bay Area, June 4, 2017
- Are there any shortcuts on the translation highway to genomic medicine?
MJ Khoury, CDC Blog Post, June 1, 2017
- Precision Public Health: Panacea or Contradiction in Terms?
Thomas A. Pearson, slide presentation, University of Florida
- Reconciling evidence-based medicine and precision medicine in the era of big data: challenges and opportunities.
Beckmann Jacques S et al. Genome medicine 2016 8(1) 134
- Strength in Numbers: genetic sequencing of large populations is shaping the future of medicine
RL Collins, Harvard School of Arts and Sciences, June 5, 2017
Disclaimer: Articles listed in Health Impact Weekly Scan are selected by the CDC Office of Public Health Genomics to provide current awareness of the scientific literature and news. Inclusion in the update does not necessarily represent the views of the Centers for Disease Control and Prevention nor does it imply endorsement of the article's methods or findings. CDC and DHHS assume no responsibility for the factual accuracy of the items presented. The selection, omission, or content of items does not imply any endorsement or other position taken by CDC or DHHS. Opinion, findings and conclusions expressed by the original authors of items included in the Clips, or persons quoted therein, are strictly their own and are in no way meant to represent the opinion or views of CDC or DHHS. References to publications, news sources, and non-CDC Websites are provided solely for informational purposes and do not imply endorsement by CDC or DHHS.
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