From Tier Table Database
CDC Office of Public Health Genomics (OPHG) conducts horizon scanning (a systematic research method to find and follow novel technologies appearing in the literature) to identify and track the progress of genomic tests as they move from research into clinical and public health practice. As an aid in organizing horizon scanning results, OPHG ranks genomic tests, and family health history applications, by levels of evidence. See detail.
| Disease/Disorder | Test or Application | Intended Use | Tier Classified | Detail |
|---|---|---|---|---|
| Personal or family history of breast cancer or ovarian cancer | Genetic counseling | Risk prediction for hereditary breast and ovarian cancer syndrome | Tier 1  | |
| BRCA-related cancer; hereditary breast and ovarian cancer | Family history of breast and/or ovarian cancer in third-degree relative, who has additional specified familial risk factors* | Risk prediction for referral to further risk assessment, genetic counseling, and possibly genetic testing | Tier 1 | |
| BRCA-related cancer; hereditary breast and ovarian cancer | Family history in first- or second-degree relative with one or more specified risk factors* | Risk prediction for referral to further risk assessment, genetic counseling, and possibly genetic testing | Tier 1 | |
| Common diseases | Screening | Risk prediction | Tier 2 |
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