herenciageneticayenfermedad: Pulmonology

jueves, 28 de diciembre de 2017

Pulmonology - Dec 27, 2017 Edition

	December 27, 2017
	Pulmonology
	The latest pulmonology news from News Medical

	Reduced activity of transcription factor plays key role in triggering pulmonary fibrosis To date, the molecular basis of pulmonary fibrosis has been poorly understood. Scientists from the Max Planck Institute for Heart and Lung Research in Bad Nauheim have now shown that reduced activity of the transcription factor FoxO3 plays a key role in the development of the disease.

	Untreated and overweight children may have worse asthma symptoms Asthma affects almost 1 in 10 children in the U.S. and is a leading cause of emergency room visits and hospitalizations in preschoolers. According to new research from Duke Health and collaborators, symptoms may be worse for children ages 2 to 5 who are overweight.

			Scientists discover five new regions of the genome that increase asthma risk An international study led by scientists from Inserm and Paris Diderot Universit, the University of Chicago, the National Heart and Lung Institute and the University of Colorado Anschutz Medical Campus together with researchers of the Trans-National Asthma Genetics Consortium has discovered five new regions of the genome that increase the risk of asthma.

			Coarse particulate matter exposure linked to increased asthma risk in children Children exposed to coarse particulate matter may be more likely to develop asthma and to be treated in an ER or be hospitalized for the condition, according to new research published online in the American Thoracic Society's American Journal of Respiratory and Critical Care Medicine.

			FeNO test may be helpful tool that aids in asthma diagnosis Although about 24 million Americans are diagnosed with asthma every year, there is no single test that can diagnose the disease. Common symptoms, such as shortness of breath, wheezing, and cough, are relatively nonspecific, and physicians may use multiple tests and observations to reach an accurate diagnosis.

	Protein structure could pave way for effective drugs to treat cystic fibrosis Biochemists at the University of Zurich have used cryo-electron microscopy to determine the detailed architecture of the chloride channel TMEM16A. This protein is a promising target for the development of effective drugs to treat cystic fibrosis.

	Targeted lung cancer treatments may benefit smokers and non-smokers alike Smokers are less likely than non-smokers to have lung cancers caused by targetable genetic changes. But a study published this week in the journal Clinical Cancer Research shows that when they do, smokers benefit just as much as non-smokers from targeted treatments.

	Study explores use of radiosurgery in lung cancer patients with multiple brain metastases Although targeted therapies have produced dramatic advances in our ability to control some types of advanced lung cancer, growth of the disease in the brain remains a major problem.

	Loyola Medicine otolaryngologist corrects sleep apnea symptoms with ENT procedure For Jason Johnson, nights were anything but restful. The 16-year-old high school student would often wake up with difficulty breathing.

	Relieving Symptoms of Cystic Fibrosis with Exercise We know that exercise is beneficial in helping someone to maintain their lung function, stay strong and active and maintain a good quality of life. We also know that exercise can complement ‘airway clearance techniques’ – breathing exercises prescribed by physiotherapists to help clear the lungs of mucus.

	New guide provides evidence-based overview of key sleep challenges faced by women Though sleep is essential to health and wellbeing, the unique barriers faced by women in maintaining good sleep health are often misunderstood or overlooked, according to a new resource "Women & Sleep: A Guide for Better Health" developed by the Society for Women's Health Research Interdisciplinary Network on Sleep.

	Valley fever cases see sharp increase in November, say UVA experts Valley fever cases in November saw a 50-percent spike over the previous month, leading experts at the University of Arizona Valley Fever Center for Excellence to predict a significant increase in cases in 2018.

	Human ‘common cold’ virus kills healthy chimpanzees in Uganda In the wild, chimpanzees face any number of dire threats, ranging from poachers to predators to deforestation.

	Study: Allergens found to be widespread, but highly variable in U.S. homes Allergens are widespread, but highly variable in U.S. homes, according to the nation's largest indoor allergen study to date. Researchers from the National Institutes of Health report that over 90 percent of homes had three or more detectable allergens, and 73 percent of homes had at least one allergen at elevated levels.

	Study finds narrowed upper airways in preterm infants that may explain higher OSA risk Infants born preterm have significantly lower nasopharyngeal and oropharyngeal volumes, compared with newborn peers carried to full term, and those lower airway volumes are independent of the infants' gender, ethnicity or weight, according to a study published online Dec. 16, 2017 in Clinical Imaging.

	Nanobiotix receives FDA approval for first immuno-oncology trial NANOBIOTIX, a late clinical-stage nanomedicine company pioneering new approaches to the treatment of cancer, today announced the U.S.

	Steroid study provides new insights into medicines' side effects Fresh insights into key hormones found in commonly prescribed medicines have been discovered, providing further understanding of the medicines' side effects.

	Higher ‘mutational burden’ of tumors predicts success rate with cancer immunotherapies The "mutational burden," or the number of mutations present in a tumor's DNA, is a good predictor of whether that cancer type will respond to a class of cancer immunotherapy drugs known as checkpoint inhibitors, a new study led by Johns Hopkins Kimmel Cancer Center researchers shows.

	Children's Colorado and RxRevu partner to help prescribers better meet needs of pediatric patients Children's Hospital Colorado (Children's Colorado) and RxRevu, the leader in prescription-decision support, are collaborating to help prescribers better meet the needs of children by seamlessly incorporating antimicrobial-stewardship best practices into prescribers' decision-making processes.