Molecules of Neural Disorders

Molecular Brain

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• ​​​​​​​Molecular Brain is affiliated with the Association for the Study of Neurons and Disease(AND).

Molecules of Neural Disorders

Reviews in this themed series were commissioned by Professors Tim Bliss, Satoshi Kida and Graham Collingridge.
All submissions were handled by Tim Bliss and were independently and externally peer-reviewed.   

1. Content Type:Research

   Fibronectin type III domain-containing protein 5 interacts with APP and decreases amyloid β production in Alzheimer’s disease

   The deposition of Amyloid-beta peptides (Aβ) is detected at an earlier stage in Alzheimer’s disease (AD) pathology. Thus, the approach toward Aβ metabolism is considered to play a critical role in the onset an...

   Authors:Yasuha Noda, Akira Kuzuya, Kyousuke Tanigawa, Mitsugu Araki, Ryoko Kawai, Biao Ma, Yoko Sasakura, Masato Maesako, Yoshitaka Tashiro, Masakazu Miyamoto, Kengo Uemura, Yasushi Okuno and Ayae Kinoshita

   Citation:Molecular Brain 2018 11:61

   Published on: 24 October 2018

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2. Content Type:Review

   Targeting NMDA receptors in stroke: new hope in neuroprotection

   NMDA (N-methyl-d-aspartate) receptors (NMDARs) play a central role in excitotoxic neuronal death caused by ischemic stroke, but NMDAR channel blockers have failed to be translated into clinical stroke treatmen...

   Authors:Qiu Jing Wu and Michael Tymianski

   Citation:Molecular Brain 2018 11:15

   Published on: 13 March 2018

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3. Content Type:Research

   Antidepressant-like effects of translocator protein (18 kDa) ligand ZBD-2 in mouse models of postpartum depression

   The 18 kDa translocator protein (TSPO) is primarily localized in the outer mitochondrial membrane of steroid-synthesizing cells in the central and peripheral nervous systems. One of the protein’s main function...

   Authors:Xu-bo Li, An Liu, Le Yang, Kun Zhang, Yu-mei Wu, Ming-gao Zhao and Shui-bing Liu

   Citation:Molecular Brain 2018 11:12

   Published on: 5 March 2018

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4. Content Type:Research

   Hippocampal calpain is required for the consolidation and reconsolidation but not extinction of contextual fear memory

   Memory consolidation, reconsolidation, and extinction have been shown to share similar molecular signatures, including new gene expression. Calpain is a Ca2+-dependent protease that exerts its effects through the...

   Authors:Taikai Nagayoshi, Kiichiro Isoda, Nori Mamiya and Satoshi Kida

   Citation:Molecular Brain 2017 10:61

   Published on: 19 December 2017

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5. Content Type:Review

   Role of GABAA receptors in alcohol use disorders suggested by chronic intermittent ethanol (CIE) rodent model

   GABAergic inhibitory transmission is involved in the acute and chronic effects of ethanol on the brain and behavior. One-dose ethanol exposure induces transient plastic changes in GABAA receptor subunit levels, c...

   Authors:Richard W. Olsen and Jing Liang

   Citation:Molecular Brain 2017 10:45

   Published on: 20 September 2017

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6. Content Type:Review

   The role of 5-HT receptors in depression

   Depression is a polygenic and highly complex psychiatric disorder that remains a major burden on society. Antidepressants, such as selective serotonin reuptake inhibitors (SSRIs), are some of the most commonly...

   Authors:Christine N. Yohn, Mark M. Gergues and Benjamin Adam Samuels

   Citation:Molecular Brain 2017 10:28

   Published on: 24 June 2017

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7. Content Type:Review

   Synaptoimmunology - roles in health and disease

   Mounting evidence suggests that the nervous and immune systems are intricately linked. Many proteins first identified in the immune system have since been detected at synapses, playing different roles in norma...

   Authors:Robert Nisticò, Eric Salter, Celine Nicolas, Marco Feligioni, Dalila Mango, Zuner A. Bortolotto, Pierre Gressens, Graham L. Collingridge and Stephane Peineau

   Citation:Molecular Brain 2017 10:26

   Published on: 20 June 2017

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8. Content Type:Review

   Propagation of Tau aggregates

   Since 2009, evidence has accumulated to suggest that Tau aggregates form first in a small number of brain cells, from where they propagate to other regions, resulting in neurodegeneration and disease. Propagat...

   Authors:Michel Goedert and Maria Grazia Spillantini

   Citation:Molecular Brain 2017 10:18

   Published on: 30 May 2017

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9. Content Type:Review

   Cortical kainate receptors and behavioral anxiety

   The study of glutamatergic synapses mainly focuses on the memory-related hippocampus. Recent studies in the cortical areas such as the anterior cingulate cortex (ACC) show that excitatory synapses can undergo ...

   Authors:Min Zhuo

   Citation:Molecular Brain 2017 10:16

   Published on: 18 May 2017

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10. Content Type:Review

    Targeting metabotropic glutamate receptors for novel treatments of schizophrenia

    Support for the N-methyl-d-aspartate receptor (NMDAR) hypofunction hypothesis of schizophrenia has led to increasing focus on restoring proper glutamatergic signaling as an approach for treatment of this devastat...

    Authors:James Maksymetz, Sean P. Moran and P. Jeffrey Conn

    Citation:Molecular Brain 2017 10:15

    Published on: 26 April 2017

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11. Content Type:Review

    Molecules in pain and sex: a developing story

    Microglia are dynamic immune cells with diverse roles in maintaining homeostasis of the central nervous system. Dysregulation of microglia has been critically implicated in the genesis of neuropathic pain. Per...

    Authors:Josiane C. S. Mapplebeck, Simon Beggs and Michael W. Salter

    Citation:Molecular Brain 2017 10:9

    Published on: 7 March 2017

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12. Content Type:Review

    Calcium/calmodulin-dependent kinase II and Alzheimer’s disease

    CaMKII is a remarkably complex protein kinase, known to have a fundamental role in synaptic plasticity and memory formation. Further, CaMKII has also been suggested to be a tau kinase. CaMKII dysregulation may...

    Authors:Anshua Ghosh and Karl Peter Giese

    Citation:Molecular Brain 2015 8:78

    Published on: 24 November 2015

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13. Content Type:Review

    Understanding the molecular basis of autism in a dish using hiPSCs-derived neurons from ASD patients

    Autism spectrum disorder (ASD) is a complex neurodevelopmental disorder characterized by deficits in social cognition, language development, and repetitive/restricted behaviors. Due to the complexity and heter...

    Authors:Chae-Seok Lim, Jung-eun Yang, You-Kyung Lee, Kyungmin Lee, Jin-A Lee and Bong-Kiun Kaang

    Citation:Molecular Brain 2015 8:57

    Published on: 30 September 2015

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