Trauma-induced coagulopathy and critical bleeding

Trauma-induced coagulopathy and critical bleeding

Edited by Professor Shigeki Kushimoto

This thematic series was published in Journal of Intensive Care

Hemorrhage is the most important contributing factor of acute-phase mortality in trauma patients. During the last 10 years, there has been a dramatic evolution in our understanding of trauma-induced coagulopathy. For example, trauma itself and traumatic shock-induced endogenous coagulopathy are both referred to as acute traumatic coagulopathy (ATC) and multifactorial trauma-associated coagulation impairment. Alongside these understandings, a widespread paradigm shift in the resuscitation of critically injured patients has been observed. Understanding the pathophysiology of trauma-induced coagulopathy and novel therapeutic strategies are therefore vitally important issues for the management of patients with severe trauma.

1. Content Type:Review

   Pathophysiology of trauma-induced coagulopathy: disseminated intravascular coagulation with the fibrinolytic phenotype

   In severe trauma patients, coagulopathy is frequently observed in the acute phase of trauma. Trauma-induced coagulopathy is coagulopathy caused by the trauma itself. The pathophysiology of trauma-induced coagu...

   Authors:Mineji Hayakawa

   Citation:Journal of Intensive Care 2017 5:14

   Published on: 31 January 2017

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2. Content Type:Review

   Permissive hypotension/hypotensive resuscitation and restricted/controlled resuscitation in patients with severe trauma

   Achieving a balance between organ perfusion and hemostasis is critical for optimal fluid resuscitation in patients with severe trauma. The concept of “permissive hypotension” refers to managing trauma patients...

   Authors:Daisuke Kudo, Yoshitaro Yoshida and Shigeki Kushimoto

   Citation:Journal of Intensive Care 2017 5:11

   Published on: 20 January 2017

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3. Content Type:Review

   Monitoring the coagulation status of trauma patients with viscoelastic devices

   Coagulopathy is a physiological response to massive bleeding that frequently occurs after severe trauma and is an independent predictive factor for mortality. Therefore, it is very important to grasp the coagu...

   Authors:Yuichiro Sakamoto, Hiroyuki Koami and Toru Miike

   Citation:Journal of Intensive Care 2017 5:7

   Published on: 20 January 2017

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4. Content Type:Review

   Acute traumatic coagulopathy and trauma-induced coagulopathy: an overview

   Hemorrhage is the most important contributing factor of acute-phase mortality in trauma patients. Previously, traumatologists and investigators identified iatrogenic and resuscitation-associated causes of coag...

   Authors:Shigeki Kushimoto, Daisuke Kudo and Yu Kawazoe

   Citation:Journal of Intensive Care 2017 5:6

   Published on: 20 January 2017

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5. Content Type:Review

   Tranexamic acid and trauma-induced coagulopathy

   Tranexamic acid (TXA) is a synthetic derivative of the amino acid lysine that inhibits fibrinolysis by blocking the interaction of plasminogen with the lysine residues of fibrin. Historically, TXA is commonly ...

   Authors:Takeshi Nishida, Takahiro Kinoshita and Kazuma Yamakawa

   Citation:Journal of Intensive Care 2017 5:5

   Published on: 20 January 2017

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6. Content Type:Review

   Damage control resuscitation: a practical approach for severely hemorrhagic patients and its effects on trauma surgery

   Coagulopathy observed in trauma patients was thought to be a resuscitation-associated phenomenon. The replacement of lost and consumed coagulation factors was the mainstay in the resuscitation of hemorrhagic s...

   Authors:Yasumitsu Mizobata

   Citation:Journal of Intensive Care 2017 5:4

   Published on: 20 January 2017

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7. Content Type:Review

   Dynamics of fibrinogen in acute phases of trauma

   Fibrinogen is a unique precursor of fibrin and cannot be compensated for by other coagulation factors. If plasma fibrinogen concentrations are insufficient, hemostatic clots cannot be formed with the appropria...

   Authors:Mineji Hayakawa

   Citation:Journal of Intensive Care 2017 5:3

   Published on: 20 January 2017

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8. Content Type:Review

   Trauma-induced coagulopathy and critical bleeding: the role of plasma and platelet transfusion

   Hemorrhage is responsible for 30 to 40% of all trauma-related mortality. Among adult trauma patients, 94% of hemorrhage-related deaths occur within 24 h and approximately 60% of these deaths within 3 h of hosp...

   Authors:Hiroyasu Ishikura and Taisuke Kitamura

   Citation:Journal of Intensive Care 2017 5:2

   Published on: 20 January 2017

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