martes, 5 de marzo de 2019

Virology Journal | Hepatitis viruses

Virology Journal | Hepatitis viruses



Hepatitis viruses

Section Editor: Alan McLachlan, University of Illinois at Chicago, USA 
Deputy Section Editor: Susan Uprichard, Loyola University Medical Center​​​​​​​, USA 
The Hepatitis viruses section of Virology Journal includes studies relating to all aspects of hepatitis A, B C, D and E virus research including research discoveries addressing both basic and medical aspects of the biology of these human pathogens. Basic research topics of interest include all aspects of the viral life cycle (e.g. viral entry, intracellular capsid transport and disassembly, viral gene expression/regulation, protein processing/regulation, viral genome replication, particle assembly and egress) and viral-host interactions. Medical research topics of interest include but are not limited to viral pathogenesis, epidemiology, immunology, therapies and emergence of drug-resistant variants.
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  1. Content Type:Short Report

    HCV exhibits a high genetic diversity and is classified into 7 genotypes which are further divided into 86 confirmed subtypes. However, there are multiple isolates with unassigned subtypes. We aimed to amplify...
    Authors:Bo Wang, Luise Krüger, Patrycja Machnowska, Amare Eshetu, Barbara Gunsenheimer-Bartmeyer, Viviane Bremer, Andrea Hauser, Norbert Bannert and C.-Thomas Bock
    Citation:Virology Journal 2019 16:28
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  2. Content Type:Research

    To examine the epidemiological trends and changes of hepatitis E virus (HEV) infection and the potential risk factors for severe infection in the Zhejiang eastern coastal area of China.
    Authors:Jun Tan, Yijuan Chen, Lin Wang, Ta-Chien Chan, Said Amer, Xiaobin Xu, Jian Cai, Wei Li, Xiaoqing Zheng, Mi Zhou, Shuwen Qin, Na Zhao, Ziping Miao and Shelan Liu
    Citation:Virology Journal 2019 16:16
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  3. Content Type:Research

    Data on the treatment of patients with hepatitis C virus (HCV)/human immunodeficiency virus (HIV) coinfection remains limited. A comprehensive analysis was performed to evaluate the efficacy and safety of ombi...
    Authors:Jingjing Wu, Peng Huang, Haozhi Fan, Ting Tian, Xueshan Xia, Zuqiang Fu, Yan Wang, Xiangyu Ye, Ming Yue and Yun Zhang
    Citation:Virology Journal 2019 16:11
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  4. Content Type:Research

    Men who have sex with men (MSM) are considered to be at significant risk for sexually transmitted infections (STI) and bloodborne viruses including viral hepatitis types B, C, and D (HBV, HCV, and HDV) and hum...
    Authors:Henri Gautier Ouedraogo, Seni Kouanda, Ashley Grosso, Rebecca Compaoré, Modibo Camara, Charlemagne Dabire, Rasmata Ouedraogo, Yves Traore, Stefan Baral and Nicolas Barro
    Citation:Virology Journal 2018 15:194
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  5. Content Type:Research

    Hepatitis B virus is a hepatotropic DNA virus that reproduces via an RNA intermediate. It can lead to an increased risk of serious liver diseases such as hepatocellular carcinoma and is a serious threat to pub...
    Authors:Lei Jia, Fengyu Hu, Hanping Li, Lin Li, Xiaoping Tang, Yongjian Liu, Haohui Deng, Jingwan Han, Jingyun Li and Weiping Cai
    Citation:Virology Journal 2018 15:188
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  6. Content Type:Review

    The recently approved interferon-free DAA (direct antiviral agents) regimens have shown not only to be effective in terms of sustained virological response (SVR) rates (> 90%) but also well tolerated in most h...
    Authors:Antonio Di Biagio, Lucia Taramasso and Giovanni Cenderello
    Citation:Virology Journal 2018 15:180
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  7. Content Type:Short Report

    In 2017 the Nigerian Ministry of Health notified the World Health Organization (WHO) of an outbreak of hepatitis E located in the north-east region of the country with 146 cases with 2 deaths. The analysis of ...
    Authors:Bo Wang, Olusola Anuoluwapo Akanbi, Dominik Harms, Olufisayo Adesina, Folakemi Abiodun Osundare, Dhamari Naidoo, Isabel Deveaux, Opeayo Ogundiran, Uzoma Ugochukwu, Nwando Mba, Chikwe Ihekweazu and C.-Thomas Bock
    Citation:Virology Journal 2018 15:163
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  8. Content Type:Research

    Transjugular intrahepatic portosystemic shunt (TIPS) procedure has played a vital role in management of portal hypertension. Thus, we aimed to investigate the natural history, long-term clinical outcome, predi...
    Authors:Dengke Teng, Hao Zuo, Lin Liu, Jinghui Dong and Lei Ding
    Citation:Virology Journal 2018 15:151
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  9. Content Type:Research

    Chronic hepatitis C virus (HCV) genotype (GT) 3 infection with advanced liver disease has emerged as a challenging to treat by direct-acting antivirals (DAAs), but the efficacy of DAAs in Chinese HCV-GT3 patie...
    Authors:Ya-Chao Tao, Rong Deng, Meng-Lan Wang, Duo-Duo Lv, Man Yuan, Yong-Hong Wang, En-Qiang Chen and Hong Tang
    Citation:Virology Journal 2018 15:150
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  11. Content Type:Research

    We evaluated the frequency of naturally occurring resistance associated substitutions (RASs) and their characteristic of polymorphic or non-polymorphic amino acid change to direct acting antivirals (DAAs) in N...
    Authors:Sabrina Bagaglio, Caterina Uberti-Foppa, Alessandro Olgiati, Emanuela Messina, Hamid Hasson, Camilla Ferri and Giulia Morsica
    Citation:Virology Journal 2018 15:144
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  13. Content Type:Research

    Burkina Faso is a high endemicity country for HBV infection. However, there are few data on vaccine coverage against HBV. The aim of this study was to contribute to the improvement of HBV vaccine coverage in O...
    Authors:Birama Diarra, Albert Theophane Yonli, Abdoul Karim Ouattara, Theodora Mahoukèdè Zohoncon, Lassina Traore, Christelle Nadembega, Dorcas Obiri-Yeboah, Justine Yara, Virginio Pietra, Paul Ouedraogo, Alain Bougouma, Rokia Sanogo and Jacques Simpore
    Citation:Virology Journal 2018 15:121
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  14. Content Type:Research

    A new promising therapeutic approach has emerged for patients chronically infected by the hepatitis B virus (HBV) with the development of a non-replicative adenovirus vector vaccine candidate (Ad-HBV). The vac...
    Authors:Xuefeng Zhang, Jing Wang, Jing Lu, Rongrong Li and Shuli Zhao
    Citation:Virology Journal 2018 15:111
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    The Correction to this article has been published in Virology Journal 2018 15:137
  15. Content Type:Research

    A treatment of HCV infection depends on the genotype and sub-genotype. Therefore, accurate HCV genotyping is critical for selecting the appropriate treatment regimen.
    Authors:Shrikant Dasharath Warkad, Satish Balasaheb Nimse, Keum-Soo Song, Wasun Chantratita, Viroj Pongthanapisith, Laxman Uddhav Nawale and Taisun Kim
    Citation:Virology Journal 2018 15:107
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  16. Content Type:Research

    Chinese woodchucks (M. himalayana) were recently found to be susceptible to woodchuck hepatitis virus (WHV) infection. In this study, we aimed to determine the susceptibility to WHV infection of M. himalayana fro...
    Authors:Bin Zhu, Zhenni Zhu, Junzhong Wang, Shunmei Huang, Fanghui Li, Lu Wang, Yanan Liu, Qi Yan, Shunchang Zhou, Mengji Lu, Dongliang Yang and Baoju Wang
    Citation:Virology Journal 2018 15:101
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  17. Content Type:Research

    Hepatitis B virus (HBV) chronically infects approximately 350 million people worldwide, causing a major risk of liver disease and hepatocellular carcinoma (HCC). Many mouse models have been tried to establish ...
    Authors:Xian Wang, Jianmin Zhu, Yong Zhang, Yue Li, Tai Ma, Qun Li, Jiegou Xu and Long Xu
    Citation:Virology Journal 2018 15:89
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  18. Content Type:Research

    Hepatocytes infected by hepatitis B virus (HBV) produce different HBV RNA species, including pregenomic RNA (pgRNA), which is reverse transcribed during replication. Particles containing HBV RNA are present in...
    Authors:Kasthuri Prakash, Gustaf E. Rydell, Simon B. Larsson, Maria Andersson, Gunnar Norkrans, Heléne Norder and Magnus Lindh
    Citation:Virology Journal 2018 15:86
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  19. Content Type:Research

    To investigate the predictive capability of microRNAs (miRNAs) prior treatment for HBsAg clearance in chronic hepatitis B (CHB) treated with pegylated interferon α-2a (PEG-IFNα-2a).
    Authors:Yanlin Yang, Ming Liu, Ying Deng, Yan Guo, Xuqing Zhang, Dedong Xiang, Li Jiang, Zhonglan You, Yi Wu, Maoshi Li and Qing Mao
    Citation:Virology Journal 2018 15:73
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  20. Content Type:Research

    It has been reported that the emergence of HBV rtA181T/sW172* mutant could result in a dominant secretion defect of HBsAg and increase the risk of HCC development. This study was designed to reveal the role an...
    Authors:Meng-Lan Wang, Dong-Bo Wu, Ya-Chao Tao, Lan-Lan Chen, Cui-Ping Liu, En-Qiang Chen and Hong Tang
    Citation:Virology Journal 2018 15:61
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  21. Content Type:Research

    Host single-nucleotide polymorphisms (SNPs) near the interleukin 28B (IL28B) locus are associated with sustained virological response to antiviral therapy and with spontaneous Hepatitis C Virus (HCV) clearance. P...
    Authors:Natalia Echeverría, Daniela Chiodi, Pablo López, Adriana Sanchez Ciceron, Jenniffer Angulo, Marcelo López-Lastra, Paola Silvera, Adrian Canavesi, Carla Bianchi, Valentina Colistro, Juan Cristina, Nelia Hernandez and Pilar Moreno
    Citation:Virology Journal 2018 15:40
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  22. Content Type:Review

    Hepatitis C virus (HCV) infection is a worldwide public health burden and it is estimated that 185 million people are or have previously been infected worldwide. There is no effective vaccine for prevention of...
    Authors:Ana Carolina Gomes Jardim, Jacqueline Farinha Shimizu, Paula Rahal and Mark Harris
    Citation:Virology Journal 2018 15:34
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  23. Content Type:Research

    Simeprevir is approved with pegylated interferon and ribavirin (PR) for chronic hepatitis C virus (HCV) genotype (GT) 1 and GT4 infection in the USA and the European Union.
    Authors:Fabien Zoulim, Christophe Moreno, Samuel S. Lee, Peter Buggisch, Andrzej Horban, Eric Lawitz, Chris Corbett, Oliver Lenz, Bart Fevery, Thierry Verbinnen, Umesh Shukla and Wolfgang Jessner
    Citation:Virology Journal 2018 15:26
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  24. Content Type:Research

    Previous published studies have reported conflicting results of association between hepatitis B virus (HBV) infection and preeclampsia. There was no published data on HBV and preeclampsia in Africa including S...
    Authors:Mohamed A. Ahmed, Manal E. Sharif, Duria A. Rayis, Abubakr M. Nasr and Ishag Adam
    Citation:Virology Journal 2018 15:20
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  25. Content Type:Research

    The treatment of hepatitis C virus (HCV) in HCV/human immunodeficiency virus (HIV) co-infected patients remains complex. This present meta-analysis evaluated the efficacy and safety of Sofosbuvir (SOF) for tre...
    Authors:Guotao Li, Ke Zang, Guoqiang Zhang, Danyan Zhu and Xiaozhao Deng
    Citation:Virology Journal 2018 15:19
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  26. Content Type:Research

    An association between hepatitis C virus (HCV) and type 2 diabetes (T2D) is supported by numerous epidemiologic studies. We hypothesized that HCV could infect human pancreatic islet cells in vitro.
    Authors:Jason T. Blackard, Ling Kong, Angela Lombardi, Dirk Homann, Sara Salehi Hammerstad and Yaron Tomer
    Citation:Virology Journal 2017 14:237
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  27. Content Type:Research

    It has been widely accepted that hepatitis B virus X protein (HBx) plays an important role in hepatocellular carcinoma (HCC). This study aimed to explore the function of long non-coding RNAs (lncRNAs) in the e...
    Authors:Yinji Jin, Di Wu, Weiwei Yang, Mingjiao Weng, Yafei Li, Xuefei Wang, Xiao Zhang, Xiaoming Jin and Tianzhen Wang
    Citation:Virology Journal 2017 14:238
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  28. Content Type:Research

    Direct acting antivirals (DAAs) provide efficient hepatitis C virus (HCV) therapy and clearance for a majority of patients, but are not available or effective for all patients. They risk developing HCV-induced...
    Authors:Sara M. Ø. Solbak, Eldar Abdurakhmanov, Anni Vedeler and U. Helena Danielson
    Citation:Virology Journal 2017 14:236
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  29. Content Type:Research

    Recently, human leukocyte antigen (HLA) class-II gene polymorphisms have been reported to be related to Hepatitis C virus (HCV) infection and chronicity. The objective of this study was to explore the relationshi...
    Authors:Peng Huang, Haozhi Fan, Ting Tian, Peiwen Liao, Jun Li, Rongbin Yu, Xueshan Xia, Yue Feng, Jie Wang, Yuan Liu, Yun Zhang and Ming Yue
    Citation:Virology Journal 2017 14:235
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  30. Content Type:Research

    Infection with the hepatitis E virus (HEV) can cause acute hepatitis in endemic areas in immune-competent hosts, as well as chronic infection in immune-compromised subjects in non-endemic areas. Most studies a...
    Authors:Ananta Shrestha, Anurag Adhikari, Manjula Bhattarai, Ramanuj Rauniyar, Jose D. Debes, André Boonstra, Thupten K. Lama, Mamun Al Mahtab, Amna Subhan Butt, Sheikh Mohammad Fazle Akbar, Nirmal Aryal, Sapana Karn, Krishna Das Manandhar and Birendra Prasad Gupta
    Citation:Virology Journal 2017 14:228
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  31. Content Type:Research

    Hepatitis C virus (HCV) genotypes and subtypes are considered an important tool for epidemiological and clinical studies and valuable markers for disease progression and response to antiviral therapy. The aim ...
    Authors:Amen Bawazir, Fahad AlGusheri, Hoda Jradi, Mohammed AlBalwi and Abdel-Galil Abdel-Gader
    Citation:Virology Journal 2017 14:208
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  32. Content Type:Research

    Hydrodynamic injection (HI) of hepatitis B virus (HBV) mouse model is an useful tool for HBV related research in vivo. However, only 40% of C57/BL6 mice injected with 10 μg HBV genome contained plasmid (pAAV-H...
    Authors:Lei Li, Sheng Li, Yun Zhou, Lu Yang, Di Zhou, Yan Yang, Mengji Lu, Dongliang Yang and Jingjiao Song
    Citation:Virology Journal 2017 14:205
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  33. Content Type:Research

    The pathogenesis of acute-on-chronic liver failure (ACLF) in chronic hepatitis B (CHB) is not well understood. The aim of this study was to investigate whether there is an association between HBV polymerase (P...
    Authors:Shan Gao, Shivali S. Joshi, Carla Osiowy, Y. Chen, Carla S. Coffin and Z-P. Duan
    Citation:Virology Journal 2017 14:203
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  34. Content Type:Research

    Occult hepatitis B infection (OBI) is defined as the presence of hepatitis B virus (HBV) DNA in the serum and/or liver in HBsAg-negative individuals. OBI is associated with the risk of viral transmission, espe...
    Authors:Yan Mardian, Yoshihiko Yano, Widya Wasityastuti, Neneng Ratnasari, Yujiao Liang, Wahyu Aristyaning Putri, Teguh Triyono and Yoshitake Hayashi
    Citation:Virology Journal 2017 14:201
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  35. Content Type:Research

    Seroprevalence of hepatitis C in Khyber Pakhtunkhwa province of Pakistan was determined by screening blood samples of expectant mothers seeking antenatal care in gynecological units of district hospitals. The ...
    Authors:Zobia Afsheen, Bashir Ahmad and Shumaila Bashir
    Citation:Virology Journal 2017 14:195
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  36. Content Type:Research

    Hepatitis B virus (HBV) infection is a serious public health problem leading to cirrhosis and hepatocellular carcinoma. As the clinical utility of current therapies is limited, the development of new therapeut...
    Authors:Huifang Li, Junru Li, Yuan Tang, Lin Lin, Zhanglian Xie, Jia Zhou, Liyun Zhang, Xiaoyong Zhang, Xiaoshan Zhao, Zhengliang Chen and Daming Zuo
    Citation:Virology Journal 2017 14:178
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  37. Content Type:Review

    There are an estimated 400 million chronic carriers of HBV worldwide; between 15 and 20 million have serological evidence of exposure to HDV. Traditionally, regions with high rates of endemicity are central an...
    Authors:Luan Felipo Botelho-Souza, Mariana Pinheiro Alves Vasconcelos, Alcione de Oliveira dos Santos, Juan Miguel Villalobos Salcedo and Deusilene Souza Vieira
    Citation:Virology Journal 2017 14:177
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  39. Content Type:Research

    Direct-acting antivirals (DAAs) for chronic hepatitis C (CHC) treatment are tolerable and highly effective in a shorter period of time than before. However, resistance-associated variants (RAVs) can affect the...
    Authors:Jung Hwan Yu, Jung Il Lee, Kwan Sik Lee and Ja Kyung Kim
    Citation:Virology Journal 2017 14:164
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  40. Content Type:Research

    The existing literature about HCV association with, and replication in mosquitoes is extremely poor. To fill this gap, we performed cellular investigations aimed at exploring (i) the capacity of HCV E1E2 glyco...
    Authors:Catherine Fallecker, Alban Caporossi, Yassine Rechoum, Frederic Garzoni, Sylvie Larrat, Olivier François, Pascal Fender, Patrice Morand, Imre Berger, Marie-Anne Petit and Emmanuel Drouet
    Citation:Virology Journal 2017 14:161
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  41. Content Type:Research

    Hepatitis C virus (HCV) is a leading cause of chronic liver disease and frequently progresses towards liver cirrhosis and Hepatocellular Carcinoma (HCC). This study aimed to determine the prevalence of HCV gen...
    Authors:Nausheen Nazir, Muhammad Rasul Jan, Amjad Ali, Muhammad Asif, Muhammad Idrees, Mohammad Nisar, Muhammad Zahoor and Naser M. Abd El-Salam
    Citation:Virology Journal 2017 14:160
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  42. Content Type:Research

    Chronic hepatitis B virus (HBV) infection remains an important public health issue. A20, a ubiquitin-editing protein encoded by tumor necrosis factor alpha-inducible protein 3 (TNFAIP3) gene, is complicated in HB...
    Authors:Na Li, Ying Shi, Pingping Zhang, Jiao Sang, Fang Li, Huan Deng, Yi Lv, Qunying Han and Zhengwen Liu
    Citation:Virology Journal 2017 14:148
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  43. Content Type:Research

    Because of shared modes of transmission, patients with hepatitis C virus (HCV) infection are often co-infected with other types of hepatitis viruses and/or HIV. We studied HCV viral load and its genotype patte...
    Authors:Marzieh Jamalidoust, Mandana Namayandeh, Mohsen Moghadami and Mazyar Ziyaeyan
    Citation:Virology Journal 2017 14:127
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  44. Content Type:Case Report

    The major resistance-associated substitution for sofosbuvir (S282T) in HCV NS5B causes severe viral fitness costs and rapidly reverts back to prototype in the absence of selection pressure. Accordingly, resist...
    Authors:Andreas Walker, Sandra Filke, Nadine Lübke, Martin Obermeier, Rolf Kaiser, Dieter Häussinger, Jörg Timm and Hans H. Bock
    Citation:Virology Journal 2017 14:106
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  45. Content Type:Research

    In study TMC647055HPC2001, a 3-direct-acting-antiviral (DAA) regimen combining NS3/4A protease inhibitor simeprevir (SMV), non-nucleoside NS5B inhibitor TMC647055/ritonavir (RTV) and NS5A inhibitor JNJ-5691484...
    Authors:Leen Vijgen, Kim Thys, An Vandebosch, Pieter Van Remoortere, René Verloes and Sandra De Meyer
    Citation:Virology Journal 2017 14:101
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  47. Content Type:Research

    Quantification Hepatitis B virus (HBV) DNA plays a critical role in the management of chronic HBV infections. However, HBV is a DNA virus with high levels of genetic variation, and drug-resistant mutations hav...
    Authors:Chao Liu, Le Chang, Tingting Jia, Fei Guo, Lu Zhang, Huimin Ji, Junpeng Zhao and Lunan Wang
    Citation:Virology Journal 2017 14:94
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  48. Content Type:Review

    Around 170–200 million individuals have hepatitis C virus (HCV), which represents ~ 3% of the world population, including ~ 3–5 million people in the USA. According to the WHO regional office in the Middle Eas...
    Authors:Mostafa H. Elberry, Noureldien H. E. Darwish and Shaker A. Mousa
    Citation:Virology Journal 2017 14:88
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  49. Content Type:Research

    Chronic hepatitis C virus (HCV) infection is an important cause of hepatocellular carcinoma (HCC). Epithelial to mesenchymal transition (EMT) is a key process associated with tumor metastasis and poor prognosi...
    Authors:Bicheng Hu, Shenggao Xie, Yuqian Hu, Wen Chen, Xiaofan Chen, Yi Zheng and Xinxing Wu
    Citation:Virology Journal 2017 14:83
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  50. Content Type:Research

    Hepatitis B virus (HBV) is the leading cause of liver cirrhosis and hepatocellular carcinoma in Asia and Africa. Existing antivirals cannot cure HBV or eliminate risk of hepatocellular carcinoma. Glucose-regul...
    Authors:Nai Q. Zheng, Zi H. Zheng, Hai X. Xu, Ming X. Huang and Xiao M. Peng
    Citation:Virology Journal 2017 14:77
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