Annals of Clinical Microbiology and Antimicrobials
Systematic review of carbapenem-resistant Enterobacteriaceae causing neonatal sepsis in China
Carbapenems are β-lactam antibiotics which are used to treat severe infections caused by multidrug resistant Enterobacteriacea. The recent emergence and rapid spread of Enterobacteriaceae resistant to carbapenems...Annals of Clinical Microbiology and Antimicrobials 2019 18:36Effect of camera monitoring and feedback along with training on hospital infection rate in a neonatal intensive care unit
In terms of pediatric healthcare-associated infections (HAI), neonatal intensive care units (NICU) constitute the greatest risk. Contacting a health care personnel, either directly or indirectly, elevates NICU...Annals of Clinical Microbiology and Antimicrobials 2019 18:35A 7-year surveillance of the drug resistance in Klebsiella pneumoniae from a primary health care center
The increased prevalence of Klebsiella pneumoniae infections and resistance rates are a current cause for concern. However, data for resistance rates in K. pneumoniae strains from primary hospitals and the resist...Annals of Clinical Microbiology and Antimicrobials 2019 18:34Doxycycline-encapsulated solid lipid nanoparticles for the enhanced antibacterial potential to treat the chronic brucellosis and preventing its relapse: in vivo study
Brucellosis is one of the most important infection of diseases. Due to its large period of treatment and survival ability of bacteria inside the macrophages, relapse of this disease is the main challenge, espe...Annals of Clinical Microbiology and Antimicrobials 2019 18:33
Exploring the phenotype and genotype of multi-drug resistant Klebsiella pneumoniae harbouring blaCTX-M group extended-spectrum β-lactamases recovered from paediatric clinical cases in Shenzhen, China
Emergence and spread of β-lactamase resistant Klebsiella pneumoniae have posed a serious threat, especially in paediatric patients globally. The present study focuses on explore drug resistance profile and molecu...Annals of Clinical Microbiology and Antimicrobials 2019 18:32The effect of concomitant fibromyalgia in HIV infected patients receiving antiretroviral therapy: a prospective cross-sectional study
HIV infected patients receiving antiretroviral therapy (ART) have extensive musculoskeletal system involvement. Arthralgia and myalgia are the most common forms. Fibromyalgia Syndrome (FMS) is a chronic pain s...Annals of Clinical Microbiology and Antimicrobials 2019 18:31DALBACEN cohort: dalbavancin as consolidation therapy in patients with endocarditis and/or bloodstream infection produced by gram-positive cocci
To analyse the effectiveness of dalbavancin (DBV) in clinical practice as consolidation therapy in patients with bloodstream infection (BSI) and/or infective endocarditis (IE) produced by gram-positive cocci (...Annals of Clinical Microbiology and Antimicrobials 2019 18:30Evaluation of serological test of Zika in an endemic area of flavivirus in the Colombian Caribbean
The Zika virus (ZIKV) is an emerging flavivirus transmitted primarily through arthropods, endemic in Africa, Asia, and the Americas, and is considered a global threat by the World Health Organization.Annals of Clinical Microbiology and Antimicrobials 2019 18:29Determining the clinical significance of co-colonization of vancomycin-resistant enterococci and methicillin-resistant Staphylococcus aureus in the intestinal tracts of patients in intensive care units: a case–control study
The emergence of vancomycin-resistant Staphylococcus aureus (VRSA) has become a global concern for public health. The proximity of vancomycin-resistant enterococcus (VRE) and methicillin-resistant S. aureus (MRSA...Annals of Clinical Microbiology and Antimicrobials 2019 18:28Detection and molecular characterization of urinary tract HIV-1 populations
Identification of all possible HIV reservoirs is an important aspect in HIV eradication efforts. The urinary tract has however not been well studied as a potential HIV reservoir. In this pilot study we molecul...Annals of Clinical Microbiology and Antimicrobials 2019 18:27Health care providers’ perceptions regarding antimicrobial stewardship programs (AMS) implementation—facilitators and challenges: a cross-sectional study in the Eastern province of Saudi Arabia
Infections result from invasions of an organism into body tissues leading to diseases and complications that might eventually lead to death. Inappropriate use of antimicrobials has led to development of antimi...Annals of Clinical Microbiology and Antimicrobials 2019 18:26Nasal colonization of methicillin resistant Staphylococcus aureus in Ethiopia: a systematic review and meta-analysis
Methicillin-resistant Staphylococcus aureus (MRSA) is one of a medically important Gram-positive bacteria, which can be harboured majorly in the nasal cavity. Risk of consequent infection in a person colonized wi...Annals of Clinical Microbiology and Antimicrobials 2019 18:25A systematic review of the impact of antifungal stewardship interventions in the United States
Antimicrobial resistance is a widely recognized public health threat, and stewardship interventions to combat this problem are well described. Less is known about antifungal stewardship (AFS) initiatives and t...Annals of Clinical Microbiology and Antimicrobials 2019 18:24Hepatosplenic abscesses in an immunocompetent child with cat-scratch disease from Peru
Cat-scratch disease (CSD) is a zoonotic infection caused by Bartonella henselae and B. clarridgeiae. The typical manifestations of CSD include regional lymphadenitis and fever. However, CSD can have a wide variet...Annals of Clinical Microbiology and Antimicrobials 2019 18:23Prevalence of Shigella species and its drug resistance pattern in Ethiopia: a systematic review and meta-analysis
Shigella species are a major cause of dysentery and may attribute for death worldwide. Currently antibiotic resistance became the critical challenges for management of infectious disease. The aim was to conduct a...Annals of Clinical Microbiology and Antimicrobials 2019 18:22CRISPR-cas system: biological function in microbes and its use to treat antimicrobial resistant pathogens
The development of antibiotic resistance in bacteria is a major public health threat. Infection rates of resistant pathogens continue to rise against nearly all antimicrobials, which has led to development of ...Annals of Clinical Microbiology and Antimicrobials 2019 18:21Antimicrobial consumption in three pediatric and neonatal intensive care units in Saudi Arabia: 33-month surveillance study
Despite their critical role in antimicrobial stewardship programs, data on antimicrobial consumption among the pediatric and neonatal population is limited internationally and lacking in Saudi Arabia. The curr...Annals of Clinical Microbiology and Antimicrobials 2019 18:20A prospective multicenter study on the evaluation of antimicrobial resistance and molecular epidemiology of multidrug-resistant Acinetobacter baumannii infections in intensive care units with clinical and environmental features
Multidrug-resistant (MDR) Acinetobacter baumannii infections are considered as emerging nosocomial infections particularly in patients hospitalized in intensive care units (ICUs). Therefore, reliable detection of...Annals of Clinical Microbiology and Antimicrobials 2019 18:19Association of prenatal antibiotics with measures of infant adiposity and the gut microbiome
Prenatal antibiotic exposure has been associated with an altered infant gut microbiome composition and higher risk of childhood obesity, but no studies have examined if prenatal antibiotics simultaneously alte...Annals of Clinical Microbiology and Antimicrobials 2019 18:18Microsporidial keratitis retrospectively diagnosed by ultrastructural study of formalin-fixed paraffin-embedded corneal tissue: a case report
The utility of formalin-fixed paraffin-embedded (FFPE) corneal tissue specimens for retrospective diagnosis of microsporidial keratitis was evaluated by transmission electron microscopy (TEM) analysis and the ...Annals of Clinical Microbiology and Antimicrobials 2019 18:17Whole-genome sequencing and characterization of an antibiotic resistant Neisseria meningitidis B isolate from a military unit in Vietnam
Invasive meningococcal disease (IMD) persists in military units in Vietnam despite the availability of antibiotics and vaccines. A hindrance to reducing the incidence of IMD in Vietnam is a lack of molecular d...Annals of Clinical Microbiology and Antimicrobials 2019 18:16Late prosthetic valve endocarditis with Mycobacterium tuberculosis after the Bentall procedure
Prosthetic valve endocarditis (PVE) is a rare but severe complication of valve replacement surgery, with an incidence rate of 0.3–1.2% per patient-year. At present, staphylococci are the predominant causative ...Annals of Clinical Microbiology and Antimicrobials 2019 18:15Streptococcus agalactiae maternal colonization, antibiotic resistance and serotype profiles in Africa: a meta-analysis
Maternal rectovaginal colonization with Streptococcus agalactiae (Group B Streptococcus or GBS) is the most common route for the GBS disease in the perinatal period. The knowledge of maternal colonization, antibi...Annals of Clinical Microbiology and Antimicrobials 2019 18:14Comparative evaluation of isavuconazonium sulfate, voriconazole, and posaconazole for the management of invasive fungal infections in an academic medical center
Invasive fungal infections are a major cause of morbidity and mortality. Newer antifungals may provide similar efficacy with improved safety compared to older more established treatments. This study aimed to c...Annals of Clinical Microbiology and Antimicrobials 2019 18:13Surface colonization and subsequent development of infections with multi drug resistant organisms in a neonatal intensive care unit
This study analyzes colonization of the neonates in a NICU and incidence of these colonized infants developing infections due to the colonizers.Annals of Clinical Microbiology and Antimicrobials 2019 18:12Frugivorous bats in the Colombian Caribbean region are reservoirs of the rabies virus
Bats are an important ecological group within ecosystems. The rabies virus is a Lyssavirus, and haematophagous bats are the principal reservoir; however, the virus has also been detected in non-haematophagous bat...Annals of Clinical Microbiology and Antimicrobials 2019 18:11Plasma cell-free DNA: a potential biomarker for early prediction of severe dengue
Considerable progress has been made in dengue management, however the lack of appropriate predictors of severity has led to huge number of unwanted admissions mostly decided on the grounds of warning signs. Ap...Annals of Clinical Microbiology and Antimicrobials 2019 18:10- Annals of Clinical Microbiology and Antimicrobials 2019 18:9
Characterization of the clonal profile of methicillin resistant Staphylococcus aureus isolated from patients with early post-operative orthopedic implant based infections
To analyze the molecular epidemiology and to compare between the major methicillin resistant Staphylococcus aureus biotypes for association with patient characteristics who had an implant for closed fracture and ...Annals of Clinical Microbiology and Antimicrobials 2019 18:8Accurate identification and epidemiological characterization of Burkholderia cepacia complex: an update
Bacteria belonging to the Burkholderia cepacia complex (Bcc) are among the most important pathogens isolated from cystic fibrosis (CF) patients and in hospital acquired infections (HAI). Accurate identification o...Annals of Clinical Microbiology and Antimicrobials 2019 18:7Antimicrobial stewardship program (ASP): an effective implementing technique for the therapy efficiency of meropenem and vancomycin antibiotics in Iranian pediatric patients
Antimicrobial stewardship program (ASP) is a distinguished method to improve the prescription and efficacy of antibiotics.Annals of Clinical Microbiology and Antimicrobials 2019 18:6The effect of malaria rapid diagnostic tests results on antimicrobial prescription practices of health care workers in Burkina Faso
Malaria rapid diagnostic tests (RDT) are widely used in endemic areas in order to comply with the recommendation that malaria treatment should only be given after the clinical diagnosis has been confirmed by R...Annals of Clinical Microbiology and Antimicrobials 2019 18:5Hypervirulent Klebsiella pneumoniae (hypermucoviscous and aerobactin positive) infection over 6 years in the elderly in China: antimicrobial resistance patterns, molecular epidemiology and risk factor
The definition of hypervirulent Klebsiella pneumoniae (hvKp), traditionally regarded as hypermucoviscosity, is controversial. However, data based on both phenotype (hypermucoviscous) and genetic (aerobactin) crit...Annals of Clinical Microbiology and Antimicrobials 2019 18:4Streptococcus agalactiae from Ethiopian pregnant women; prevalence, associated factors and antimicrobial resistance: alarming for prophylaxis
Maternal Streptococcus agalactiae (Group B Streptococcus, GBS) colonization rates and its antibiotic resistance patterns provide important information useful in guiding prevention strategies. There is a paucity o...Annals of Clinical Microbiology and Antimicrobials 2019 18:3Application of next-generation sequencing to detect variants of drug-resistant Mycobacterium tuberculosis: genotype–phenotype correlation
Drug resistance in Mycobacterium tuberculosis (MTB) is a major health issue worldwide. Recently, next-generation sequencing (NGS) technology has begun to be used to detect resistance genes of MTB. We aimed to ass...Annals of Clinical Microbiology and Antimicrobials 2019 18:2Prevalence of Acinetobacter baumannii in Saudi Arabia: risk factors, antimicrobial resistance patterns and mechanisms of carbapenem resistance
Acinetobacter baumannii is an important opportunistic pathogen due to its capabilities for developing mechanisms of resistance to a wide range of antimicrobial agents including carbapenems. This review described ...Annals of Clinical Microbiology and Antimicrobials 2019 18:1Cerebrospinal fluid penetration of very high-dose meropenem: a case report
Standard dosing of meropenem (2 g t.i.d.) produces CSF concentrations of only 1–2 mg/L which is inferior to the clinical breakpoint for most Gram-negative bacteria. There is therefore concern that dosing must ...Annals of Clinical Microbiology and Antimicrobials 2018 17:47In vivo efficacy of tobramycin-loaded synthetic calcium phosphate beads in a rabbit model of staphylococcal osteomyelitis
Osteomyelitis is an acute or chronic inflammatory process of the bone following infection with pyogenic organisms like Staphylococcus aureus. Tobramycin (TOB) is a promising aminoglycoside antibiotic used to trea...Annals of Clinical Microbiology and Antimicrobials 2018 17:46Metagenomic next-generation sequencing as a diagnostic tool for toxoplasmic encephalitis
More than 100 different pathogens can cause encephalitis. Testing of all the neurological pathogens by conventional methods can be difficult. Metagenomic next-generation sequencing (NGS) could identify the inf...Annals of Clinical Microbiology and Antimicrobials 2018 17:45Detection of bacterial DNA from central venous catheter removed from patients by next generation sequencing: a preliminary clinical study
Catheter-related infection (CRI) is one of the serious challenges in clinical practice. This preliminary clinical study aimed to examine whether next-generation sequencing (NGS) targeting 16S rDNA, which was P...Annals of Clinical Microbiology and Antimicrobials 2018 17:44Identification of pathogens in culture-negative infective endocarditis cases by metagenomic analysis
Pathogens identification is critical for the proper diagnosis and precise treatment of infective endocarditis (IE). Although blood and valve cultures are the gold standard for IE pathogens detection, many case...Annals of Clinical Microbiology and Antimicrobials 2018 17:43Adherent/invasive Escherichia coli (AIEC) isolates from asymptomatic people: new E. coli ST131 O25:H4/H30-Rx virotypes
The widespread Escherichia coli clone ST131 implicated in multidrug-resistant infections has been recently reported, the majority belonging to O25:H4 serotype and classified into five main virotypes in accordance...Annals of Clinical Microbiology and Antimicrobials 2018 17:42Microbial virulence, molecular epidemiology and pathogenic factors of fluoroquinolone-resistant Haemophilus influenzae infections in Guangzhou, China
Fluoroquinolone-resistant Haemophilus influenzae (FRHI) has been reported worldwide but remain unclear in China.Annals of Clinical Microbiology and Antimicrobials 2018 17:41Culture- and PCR-based detection of BV associated microbiological profile of the removed IUDs and correlation with the time period of IUD in place and the presence of the symptoms of genital tract infection
The long-term use of intrauterine devices (IUDs) may lead to biofilm formation on the surface. The aim of this study was to perform the culture- and PCR-based detection of bacteria/fungi from the biofilm of th...Annals of Clinical Microbiology and Antimicrobials 2018 17:40Appropriateness of empiric antimicrobial therapy with imipenem/colistin in severe septic patients: observational cohort study
Empiric antimicrobial therapy (EAMT) using imipenem/colistin is commonly prescribed as a first line therapy in critically ill patients with severe sepsis. We aimed to assess the appropriateness of prescribing ...Annals of Clinical Microbiology and Antimicrobials 2018 17:39Clindamycin suppresses virulence expression in inducible clindamycin-resistant Staphylococcus aureus strains
Clindamycin is a protein synthesis inhibitory agent that has the ability to suppress the expression of virulence factors in Staphylococcus aureus. Recent guidelines recommend the use of clindamycin for the treatm...Annals of Clinical Microbiology and Antimicrobials 2018 17:38Impact of the use of local fidaxomicin treatment algorithms for managing Clostridium difficile infection in hospitalized patients in southeastern United States
Clostridium difficile-associated diarrhea (CDAD) is a major public health threat that results in increased length of stay, hospital readmissions, deaths, and economic burden. CDAD treatment is often guided by sev...Annals of Clinical Microbiology and Antimicrobials 2018 17:37An update on gastrointestinal endoscopy-associated infections and their contributing factors
During clinical use, gastrointestinal endoscopes are grossly contaminated with patient’s native flora. These endoscopes undergo reprocessing to prevent infectious transmission upon future use. Endoscopy-associ...Annals of Clinical Microbiology and Antimicrobials 2018 17:36Mycetoma: a clinical dilemma in resource limited settings
Mycetoma is a chronic mutilating disease of the skin and the underlying tissues caused by fungi or bacteria. Although recently included in the list of neglected tropical diseases by the World Health Organizati...Annals of Clinical Microbiology and Antimicrobials 2018 17:35An evaluation of multidrug-resistant Escherichia coli isolates in urinary tract infections from Aguascalientes, Mexico: cross-sectional study
Uropathogenic Escherichia coli (UPEC) are one of the main bacteria causing urinary tract infections (UTIs). The rates of UPEC with high resistance towards antibiotics and multidrug-resistant bacteria have increas...Annals of Clinical Microbiology and Antimicrobials 2018 17:34
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