Coronavirus [NEW TOPIC PAGE]

Hot Topics of the Day|PHGKB

 Coronavirus

An Inactivated Virus Candidate Vaccine to Prevent COVID-19
MJ Mulligan, JAMA, August 13, 2020

Genetic immunization approaches are particularly suited to a rapid pandemic response. While no genetic immunization vaccine has ever been licensed by the FDA for human use, these platforms hold great promise. Genetic immunization candidates can be seen as mimics of natural infection or of traditional live-attenuated vaccines, like the measles-mumps-rubella vaccine.

The Role of Host Genetic Factors in Coronavirus Susceptibility: Review of Animal and Systematic Review of Human Literature
M LoPresti et al, AJHG, August 12, 2020

We reviewed the literature on host genetic factors related to coronaviruses. We identified 1,832 articles of potential relevance. 75 involved human host genetic factors, of which 35 involved analysis of specific genes or loci; aside from one meta-analysis, all were candidate-driven studies, typically investigating small numbers of research subjects and loci.

Predicting Critical State after COVID-19 Diagnosis Using Real-World Data from 20152 US Patients
MDR et al, MedRXIV, AUgust 11, 2020

The selection of reference genome and the search for the origin of SARS-CoV-2
Y Liu et al BIORXIV, August 11, 2020

Factors Associated with Disease Severity and Mortality among Patients with Coronavirus Disease 2019: A Systematic Review and Meta-Analysis
V Chidambaram et al, MEDRXIV, August 13, 2020

109 articles were included. The risks of mortality or severe diseases were higher in patients with increasing age, male gender, dyspnea, diabetes, hypertension, congestive heart failure, hilar lymphadenopathy, bilateral lung involvement and reticular pattern.