Coronavirus [NEW TOPIC PAGE]

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 Coronavirus

Association of Race With Mortality Among Patients Hospitalized With Coronavirus Disease 2019 (COVID-19) at 92 US Hospitals
BR Yehya et al, JAMA Network Open, August 18, 2020

In this cohort study of 11?210 individuals with COVID-19 presenting for care at 92 hospitals across 12 states, there was no difference in all-cause, in-hospital mortality between White and Black patients after adjusting for age, sex, insurance status, comorbidity, neighborhood deprivation, and site of care.

A prediction model of outcome of SARS-CoV-2 pneumonia based on laboratory findings
G Wu et al, Scientific Report, August 20, 2020

International electronic health record-derived COVID-19 clinical course profiles: the 4CE consortium
GA Brat et al, NPJ Digital Medicine, August 20, 2020

An international consortium (4CE) of 96 hospitals across five countries focuses on temporal changes in key laboratory test values. Harmonized data were analyzed locally and converted to a shared aggregate form for rapid analysis and visualization of regional differences and global commonalities. Data covered 27,584 COVID-19 cases with 187,802 laboratory tests.

Progress report on the coronavirus pandemic
Nature editorial, August 19, 2020

We look back at key scientific findings that have revealed important characteristics of the virus and COVID-19, including emerging approaches to treatment and prevention. We begin with how the virus was identified; the molecular details of its mechanism of infection; how it transmits between people; and the many ways in which it affects the human body.

Identification of potential key genes for SARS-CoV-2 infected human bronchial organoids based on bioinformatics analysis
H Gu et al, BIORXIV, August 19, 2020

No evidence for increased transmissibility from recurrent mutations in SARS-CoV-2
LV Dorp et al, BIORXIV, AUgust 19, 2020

Genome-wide bioinformatic analyses predict key host and viral factors in SARS-CoV-2 pathogenesis
MG Ferrarini et al, BIORXIV, August 19, 2020

Boosting SARS-CoV-2 qRT-PCR detection combining pool sample strategy and mathematical modeling
IA Correa et al, MEDRXIV, August 19, 2020

Multi-organ Proteomic Landscape of COVID-19 Autopsies
X Nie et al, MEDRXIV, August 19, 2020

Sequencing identifies multiple early introductions of SARS-CoV-2 to the New York City Region
MT Maurano et al, MEDRXIV, AUgust 19, 2020

Analysis of 864 SARS-CoV-2 sequences from cases in the New York City metropolitan area shows that the majority of cases had no recent travel history or known exposure, and genetically linked cases were spread throughout the region. Comparison to global viral sequences showed that early transmission was most linked to cases from Europe.

COVID-19 Among American Indian and Alaska Native Persons — 23 States, January 31–July 3, 2020
SM Hatcher et al, CDC MMWR, August 19, 2020