COVID-19 GPH|COVID-19 Genomics and Precision Public Health Weekly Update|PHGKB

COVID-19 GPH|COVID-19 Genomics and Precision Public Health Weekly Update|PHGKB

Pathogen and Human Genomics Studies

• Swabs Collected by Patients or Health Care Workers for SARS-CoV-2 Testing.
  Tu Yuan-Po et al. The New England journal of medicine 2020 07 (5) 494-496
  Our study shows the clinical usefulness of tongue, nasal, or mid-turbinate samples collected by patients as compared with nasopharyngeal samples collected by health care workers for the diagnosis of Covid-19.
• Immune complement and coagulation dysfunction in adverse outcomes of SARS-CoV-2 infection
  V Ramlall et al, Nature Medicine, August 3, 2020
  In a genetic association study of severe disease, we identified putative complement and coagulation-associated loci including missense, eQTL and sQTL variants of complement and coagulation regulators. In addition to providing evidence that complement function modulates outcome, the data point to putative transcriptional genetic markers of susceptibility.
• Genomic heterogeneity and clinical characterization of SARS-CoV-2 in Oregon
  AK Dowdell et al, MEDRXIV, August 4, 2o020
  We report viral sequences from 188 patients across the hospitals and associated clinics in Oregon dating back to the early days of the outbreak. We show a rapid emergence and dominance of Spike D614G-positive variants. We also highlight significant diversity in sequences indicative that these genomes could be utilized for outbreak tracing.