Osteoporosis: Know Your Family History ▲ Public Health Genomics Knowledge Base (v1.0)

Public Health Genomics Knowledge Base (v1.0)

Osteoporosis: Know Your Family History 

This week we highlight osteoporosis as a public health issue and the importance of family history in getting early screening.  For information on genomic insights into osteoporosis occurrence, guidelines and practice, please consult our public health genomics knowledge base.  

Last Updated: May 19, 2016

• Osteoporosis and Bone Mass Disorders: From Gene Pathways to Treatments.
  Rivadeneira Fernando et al. Trends in endocrinology and metabolism: TEM 2016 May 27(5) 262-81
• The genetics of bone mass and susceptibility to bone diseases.
  Karasik David et al. Nature reviews. Rheumatology 2016 Apr
• Does Osteoporosis Run in Your Family? 
• Bone health and vitamin D status in young epilepsy patients on valproate monotherapy.
  Albaghdadi Ola, et al. Clinical neurology and neurosurgery 2016 4 52-56
• Clinical and biochemical phenotypes of adults with monoallelic and biallelic CYP24A1 mutations: evidence of gene dose effect.
  O'Keeffe D T, et al. Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA 2016 4
• Assessment of vitamin D status and serum CrossLaps levels in adults with primary lactose malabsorption.
  Enko D, et al. European journal of clinical nutrition 2016 4
• Vitamin D receptor gene polymorphism in Egyptian pediatric acute lymphoblastic leukemia correlation with BMD.
  Tantawy Maha, et al. Meta gene 2016 9 42-6
• Worldwide variation in hip fracture incidence weakly aligns with genetic divergence between populations.
  Wallace I J, et al. Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA 2016 4
• Low bone mineral density and vitamin d deficiency correlated with genetics and other bone markers in female Turkish immigrants in Germany.
  Tastan Yasemin, et al. Clinical rheumatology 2016 3
• Implementation of personalized medicine for fracture risk assessment in osteoporosis.
  Mori Seijiro, et al. Geriatrics & gerontology international 2016 3 57-65
• [Genome-wide association study for Osteoporosis].
  Mori Seijiro, et al. Clinical calcium 2016 4 (4) 537-43
• Increased risk of strontium ranelate-related SJS/TEN is associated with HLA.
  Lee H Y, et al. Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA 2016 3
• Osteocalcin gene polymorphism and bone density in Hungarian athletes.
  Bosnyák Edit, et al. Anthropologischer Anzeiger; Bericht uber die biologisch-anthropologische Literatur 2016 3
• Polymorphisms of collagen 1A1 (COL1A1) gene and their relation to bone mineral density in postmenopausal women.
  Majchrzycki Marian, et al. Ginekologia polska 2015 12 (12) 907-14
• Cdx-2 polymorphism in Vitamin D Receptor gene was associated with serum 25-hydroxyvitamin D levels, bone mineral density and fracture in middle-aged and elderly Chinese women.
  Ling Yan, et al. Molecular and cellular endocrinology 2016 3
• Rare EN1 Variants and Pediatric Bone Mass.
  Mitchell Jonathan A, et al. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2016 3
• Vitamin D receptor BsmI polymorphism and osteoporosis risk in post-menopausal women.
  Zhao Bizeng, et al. Archives of medical science : AMS 2016 2 (1) 25-30
• The frequency of and risk factors for osteoporosis in Korean patients with rheumatoid arthritis.
  Lee Joo-Hyun, et al. BMC musculoskeletal disorders 2016 0 (1) 98
• Genetic and acquired factors influencing the effectiveness and toxicity of drug therapy in osteoporosis.
  López-Delgado Laura, et al. Expert opinion on drug metabolism & toxicology 2016 2
• The relationship of frequency of meat consumption and osteoporosis in Chinese postmenopausal women.
  Qing Guo-Zhong, et al. International journal of clinical and experimental medicine 2015 0 (11) 21130-7
• Influence of single nucleotide polymorphisms of vitamin D receptor-gene on the level of osteoassociated hormones linkage with postmenopausal osteoporosis.
  Ziablitsev D S, et al. Fiziolohichnyi? zhurnal (Kiev, Ukraine : 1994) 2015 0 (5) 21-7
• Promoter polymorphism T-786C, 894G?T at exon 7 of endothelial nitric oxide synthase gene are associated with risk of osteoporosis in Sichuan region male residents.
  Gu Zuchao, et al. International journal of clinical and experimental pathology 2015 0 (11) 15270-4
• Genetic Burden Analyses of Phenotypes Relevant to Aging in the Berlin Aging Study II (BASE-II).
  Lill Christina M, et al. Gerontology 2016 1
• Associations between vitamin D receptor gene polymorphisms and ankylosing spondylitis in Chinese Han population: a case-control study.
  Cai G, et al. Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA 2016 1
• The vitamin D status in ankylosing spondylitis in relation to intestinal inflammation, disease activity, and bone health: a cross-sectional study.
  Klingberg E, et al. Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA 2016 1
• Prevalence of osteoporosis and vitamin D receptor gene polymorphisms (FokI) in an Iranian general population based study (Kurdistan) (IMOS).
  Mohammadi Zahra, et al. Medical journal of the Islamic Republic of Iran 2015 0 238
• The Klinefelter syndrome is associated with high recurrence of copy number variations on the X chromosome with a potential role in the clinical phenotype.
  Rocca M S, et al. Andrology 2016 1
• Meta-analysis of association between IL-6 -634C/G polymorphism and osteoporosis.
  Yan L, et al. Genetics and molecular research : GMR 2015 0 (4) 19225-32
• The analysis of DKK1 polymorphisms in relation to skeletal phenotypes and bone response to alendronate treatment in Chinese postmenopausal women.
  Wang Jian-Yi, et al. Pharmacogenomics 2016 1
• Quantitative genetics of circulating Dickkopf-related protein 1 (DKK1) in community-based sample of UK twins.
  Prakash J, et al. Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA 2016 1

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• Human (4)
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Relevant Resources

• Cancer Genomics and Epidemiology Navigator (CGEN)
• Genetics and Genomics Competencies Center (G2C2)
• NIH Genetic Testing Registry
• NIH MedGen Database
• Online Mendelian Inheritance in Man (OMIM)
• PharmGKB