From CDC Information Database
This database includes general CDC public health information on specific diseases and health related topics. When available, the database displays genomic information from various CDC web pages. Users are also encouraged to conduct searches of CDC website for additional information.
- Lung Cancer Awareness
- A family health history of lung cancer is a risk factor for lung cancer
- What you can do to lower your lung cancer risk
From NIH National Cancer Institute Web Sites
From CDC-Authored Genomics Publication Database
This database contains CDC-authored publications in public health genomics including infectious diseases, newborn screening, reproductive health, genetic testing, cancer, chronic diseases, birth defects and developmental disabilities, environmental and occupational health as well as laboratory, bioinformatics and statistical methods.
- Consensus Report of the 2015 Weinman International Conference on Mesothelioma.
Carbone Michele et al. Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer 2016 Aug 11(8) 1246-62 - The microRNA-200 family targets multiple non-small cell lung cancer prognostic markers in H1299 cells and BEAS-2B cells.
Pacurari Maricica et al. Int. J. Oncol. 2013 Aug 43(2) 548-60 - Comparative effectiveness research in cancer genomics and precision medicine: current landscape and future prospects.
Simonds Naoko I et al. J. Natl. Cancer Inst. 2013 Jul 3. 105(13) 929-36 - Utilization of epidermal growth factor receptor (EGFR) testing in the United States: a case study of T3 translational research.
Lynch Julie A et al. Genet. Med. 2013 Aug 15(8) 630-8 - A smoking-associated 7-gene signature for lung cancer diagnosis and prognosis.
Wan Ying-Wooi et al. Int. J. Oncol. 2012 Oct 41(4) 1387-96
From Implementation Database
This database focuses on state and national activities that integrate genomics into public health programs and clinical practice
- Cancer Screening
[Disease: Multiple Diseases; Type: Education; State: Maine] - Genetic Testing and Cancer
[Disease: Multiple Diseases; Type: Education; State: Texas] - ASTHO Genomics and Public Health Case Study: New Frontiers for the Colorado Cancer Registry [PDF 624.93 KB]
[Disease: Lynch syndrome|Breast Cancer|Ovarian Cancer; Type: Data|Program; State: Colorado] - Healthy Woman Program
[Disease: Breast Cancer; Type: Program; State: Pennsylvania]
From Guideline Database
This database contains updated guidelines, policies and recommendations on genomic research and practice, as provided by professional organizations, federal advisory groups, expert panels and policy groups.
- National Working Group Meeting on ALK diagnostics in lung cancer.
Published 2014 (Pfizer-sponsored National Working Group Meeting on ALK Diagnostics in Lung Cancer) - Systemic Therapy for Stage IV Non-Small-Cell Lung Cancer: American Society of Clinical Oncology Clinical Practice Guideline Update.
Published 2015 (American Society of Clinical Oncology (ASCO)) - Final Recommendation Statement: Lung Cancer: Screening, December 2013
Published 2013 (US Preventive Services Task Force) - EGFR-TK mutation testing in adults with locally advanced or metastatic non-small-cell lung cancer
Published 2013 (National Institute for Health and Care Excellence) - Guideline Recommendations for EGFR Mutation Testing in Lung Cancer: Proposal of the Korean Cardiopulmonary Pathology Study Group.
Published 2013 (Korean Cardiopulmonary Pathology Study Group)
From Tier Table Database
CDC Office of Public Health Genomics (OPHG) conducts horizon scanning (a systematic research method to find and follow novel technologies appearing in the literature) to identify and track the progress of genomic tests as they move from research into clinical and public health practice. As an aid in organizing horizon scanning results, OPHG ranks genomic tests, and family health history applications, by levels of evidence. See detail.
| Disease/Disorder | Test to be Assessed | Intended Use | Tier Classified | Detail |
|---|---|---|---|---|
| Non–small cell lung cancer | KRAS mutations [except c38G>A] | Predictive; prognostic; for anti-EGFR therapy | Tier 2  | |
| Non-small cell lung cancer | ALK gene rearrangement | Pharmacogenomic for crizotinib | Tier 1 | |
| Locally advanced or metastatic non-small-cell lung cancer | EGFR (exon 19 deletions and exon 21 (L858R) substitution mutations) | Pharmacogenomic for erlotinib | Tier 1 | |
| Metastatic non-small-cell lung cancer | EGFR (exon 19 deletions and exon 21 (L858R) substitution mutations) | Pharmacogenomic for afatinib | Tier 1 |
From HuGE Literature Finder Database
This database contains published literature on genetic associations and other human genome epidemiology
- Association of Uba6-Specific-E2 (USE1) With Lung Tumorigenesis.
Journal of the National Cancer Institute 2017 Mar 109 (3): .
Kim Seong-Jin, Hyeong Lee Tae, Hee Nam Sang, Kim Ji-Hong, Oh Sangho, Sook Cho Yeon, Sup Lee Myeong, Choi Sehoon, Lee Peter C - Synonymous EGFR variant p.Q787Q is neither prognostic nor predictive in patients with lung adenocarcinoma.
Genes, chromosomes & cancer 2017 Mar 56 (3): 214-220.
Leichsenring Jonas, Volckmar Anna-Lena, Magios Nikolaus, Morais de Oliveira Cristiano Manuel, Penzel Roland, Brandt Regine, Kirchner Martina, Bozorgmehr Farastuk, Thomas Michael, Schirmacher Peter, Warth Arne, Endris Volker, Stenzinger Albrec - A novel, rapid point-of-care test for lung cancer patients to detect epidermal growth factor receptor gene mutations by using real-time droplet-PCR and fresh liquid cytology specimens.
Oncology reports 2017 Feb 37 (2): 1020-1026.
Asaka Shiho, Yoshizawa Akihiko, Matsuda Kazuyuki, Yamaguchi Akemi, Yamamoto Hiroshi, Shiina Takayuki, Nakata Rie, Ogawa Kaoru, Zhang Meng, Honda Takayu - Checkpoint Inhibitors in Metastatic EGFR-Mutated Non-Small Cell Lung Cancer-A Meta-Analysis.
Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer 2017 Feb 12 (2): 403-407.
Lee Chee Khoon, Man Johnathan, Lord Sally, Links Matthew, Gebski Val, Mok Tony, Yang James Chih-Hs - The prognostic role of EGFR-TKIs for patients with advanced non-small cell lung cancer.
Scientific reports 2017 Jan 7 40374.
Zhao Dan, Chen Xuejing, Qin Na, Su Dan, Zhou Lijuan, Zhang Quan, Li Xi, Zhang Xinyong, Jin Mulan, Wang Jingh
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