Coronavirus [NEW TOPIC PAGE]

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 Coronavirus

Risk Factors for COVID-19-associated hospitalization: COVID-19-Associated Hospitalization Surveillance Network and Behavioral Risk Factor Surveillance System
JY KO et al, MEDRXIV, July 29, 2020

In models adjusting for the presence of an individual underlying medical condition, higher hospitalization rates were observed for adults =65 years, 45-64 years (versus 18-44 years), males (versus females), and non-Hispanic black and other race/ethnicities (versus non-Hispanic whites).

High-throughput SARS-CoV-2 and host genome sequencing from single nasopharyngeal swabs
JE Gorzynski et al, MEDRXIV, July 29, 2020

There is an urgent need for efficient approaches to this data generation at scale. We have developed a scalable, high throughput approach to generate high fidelity low pass whole genome and HLA sequencing, viral genomes, and representation of human transcriptome from single nasopharyngeal swabs of COVID19 patients.

COVID-19 and School Closures
JM Donohue et al, JAMA, July 29, 2020

A precision public health approach means having easy access to real-time data to evaluate the effectiveness of specific approaches and adjust accordingly. A precision public health approach also benefits from strong collaborations. School nurses, administrators, parents, and educators need to perceive data and experts interpreting these data as trustworthy.

Association of COVID-19 inflammation with activation of the C5a–C5aR1 axis
J Carvelli et al, Nature, July 29, 2020

NIH Launches Platform to Serve as Depository for COVID-19 Medical Data
R Rubin, JAMA, July 28, 2020

Evolutionary origins of the SARS-CoV-2 sarbecovirus lineage responsible for the COVID-19 pandemic
MF Boni, Nat Microbiology, July 28, 2020

Divergence dates between SARS-CoV-2 and the bat sarbecovirus reservoir were estimated as 1948 (95% highest posterior density (HPD): 1879–1999), 1969 (95% HPD: 1930–2000) and 1982 (95% HPD: 1948–2009), indicating that the lineage giving rise to SARS-CoV-2 has been circulating unnoticed in bats for decades.