European polygenic risk score for prediction of breast cancer shows similar performance in Asian women

Weang-Kee Ho 1 2, Min-Min Tan 3 4, Nasim Mavaddat 5, Mei-Chee Tai 4, Shivaani Mariapun 3 4, Jingmei Li 6 7, Peh-Joo Ho 6, Joe Dennis 5, Jonathan P Tyrer 8, Manjeet K Bolla 5, Kyriaki Michailidou 5 9 10, Qin Wang 5, Daehee Kang 11 12 13, Ji-Yeob Choi 12 13, Suniza Jamaris 14, Xiao-Ou Shu 15, Sook-Yee Yoon 4, Sue K Park 11 12 13, Sung-Won Kim 16, Chen-Yang Shen 17 18, Jyh-Cherng Yu 19, Ern Yu Tan 20, Patrick Mun Yew Chan 20, Kenneth Muir 21, Artitaya Lophatananon 21, Anna H Wu 22, Daniel O Stram 22, Keitaro Matsuo 23 24, Hidemi Ito 23 24, Ching Wan Chan 25 26, Joanne Ngeow 27 28, Wei Sean Yong 29, Swee Ho Lim 30, Geok Hoon Lim 30, Ava Kwong 31 32 33, Tsun L Chan 31 34, Su Ming Tan 35, Jaime Seah 35, Esther M John 36, Allison W Kurian 36 37, Woon-Puay Koh 38 39, Chiea Chuen Khor 6, Motoki Iwasaki 40, Taiki Yamaji 40, Kiak Mien Veronique Tan 29 41, Kiat Tee Benita Tan 29 41, John J Spinelli 42 43, Kristan J Aronson 44, Siti Norhidayu Hasan 4, Kartini Rahmat 45, Anushya Vijayananthan 45, Xueling Sim 39, Paul D P Pharoah 5 46, Wei Zheng 15, Alison M Dunning 46, Jacques Simard 47, Rob Martinus van Dam 39 48, Cheng-Har Yip 49, Nur Aishah Mohd Taib 14, Mikael Hartman 7, Douglas F Easton 5 46, Soo-Hwang Teo 50 51, Antonis C Antoniou 5

Affiliations

PMID: 32737321
DOI: 10.1038/s41467-020-17680-w

Abstract

Polygenic risk scores (PRS) have been shown to predict breast cancer risk in European women, but their utility in Asian women is unclear. Here we evaluate the best performing PRSs for European-ancestry women using data from 17,262 breast cancer cases and 17,695 controls of Asian ancestry from 13 case-control studies, and 10,255 Chinese women from a prospective cohort (413 incident breast cancers). Compared to women in the middle quintile of the risk distribution, women in the highest 1% of PRS distribution have a ~2.7-fold risk and women in the lowest 1% of PRS distribution has ~0.4-fold risk of developing breast cancer. There is no evidence of heterogeneity in PRS performance in Chinese, Malay and Indian women. A PRS developed for European-ancestry women is also predictive of breast cancer risk in Asian women and can help in developing risk-stratified screening programmes in Asia.

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