The official journal of the Japanese Society of Inflammation and Regeneration.
Emerging roles of Toll-like receptor 9 in cardiometabolic disorders
Growing evidence suggests that damage-associated molecule patterns (DAMPs) and their receptors, pattern recognition receptors (PRRs), are associated with the progression of cardiometabolic disorders, including...Inflammation and Regeneration 2020 40:18Migration arrest of chemoresistant leukemia cells mediated by MRTF-SRF pathway
Dormant chemotherapy-resistant leukemia cells can survive for an extended period before relapse. Nevertheless, the mechanisms underlying the development of chemoresistance in vivo remain unclear.Inflammation and Regeneration 2020 40:15Immune reaction and regulation in transplantation based on pluripotent stem cell technology
The development of pluripotent stem cell (PSC)-based technologies provides us a new therapeutic approach that generates grafts for transplantation. In order to minimize the risk of immune reaction, the banking...Inflammation and Regeneration 2020 40:12Therapeutic potential of mesenchymal stem cells and their exosomes in severe novel coronavirus disease 2019 (COVID-19) cases
The novel coronavirus severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the causative agent of coronavirus disease 2019 (COVID-19) and the ensuing worldwide pandemic. The spread of the virus has ...Inflammation and Regeneration 2020 40:14- Inflammation and Regeneration 2020 40:13
Review: transcriptome and trans-omics analysis of systemic lupus erythematosus
Systemic lupus erythematosus (SLE), which was recognized as a defined clinical entity more than 100 years ago, is an archetype for systemic autoimmune diseases. The 10-year survival of SLE patients has shown d...Inflammation and Regeneration 2020 40:11Current understanding of adult neurogenesis in the mammalian brain: how does adult neurogenesis decrease with age?
Adult neurogenesis occurs throughout life in restricted brain regions in mammals. However, the number of neural stem cells (NSCs) that generate new neurons steadily decreases with age, resulting in a decrease ...Inflammation and Regeneration 2020 40:10Roles of cytotoxic lymphocytes and MIC/LILR families in pathophysiology of Takayasu arteritis
Takayasu arteritis (TAK) affects the aorta and its primary branches, mainly in young women. In its advanced stages, it can cause severe complications, such as cerebral infarction, impaired vision, and valvular...Inflammation and Regeneration 2020 40:9Metabolic remodeling during somatic cell reprogramming to induced pluripotent stem cells: involvement of hypoxia-inducible factor 1
Induced pluripotent stem cells (iPSCs) were first established from differentiated somatic cells by gene introduction of key transcription factors, OCT4, SOX2, KLF4, and c-MYC, over a decade ago. Although iPSCs...Inflammation and Regeneration 2020 40:8Osteochondrogenesis derived from synovial fibroblasts in inflammatory arthritis model
Rheumatoid arthritis (RA) is characterized by chronic joint inflammation, which forms pannus with bone destruction. Bony ankylosis is also observed following inflammation; however, the mechanism behind this ab...Inflammation and Regeneration 2020 40:7- Inflammation and Regeneration 2020 40:6
Calpain proteolytic systems counteract endothelial cell adaptation to inflammatory environments
Vascular endothelial cells (ECs) make up the innermost surface of arteries, veins, and capillaries, separating the remaining layers of the vessel wall from circulating blood. Under non-inflammatory conditions,...Inflammation and Regeneration 2020 40:5Integrins in multiple myeloma
Integrins have crucial roles in BM homing, survival, proliferation, or drug resistance of multiple myeloma (MM) cells. Especially, integrin α4β1 (VLA-4) and α4β7 has been reported to have important functions i...Inflammation and Regeneration 2020 40:4- Inflammation and Regeneration 2020 40:3
RANKL biology: bone metabolism, the immune system, and beyond
Receptor activator of NF-κB (RANK) ligand (RANKL) induces the differentiation of monocyte/macrophage–lineage cells into the bone–resorbing cells called osteoclasts. Because abnormalities in RANKL, its signalin...Inflammation and Regeneration 2020 40:2Toward the realization of cardiac regenerative medicine using pluripotent stem cells
Heart transplantation (HT) is the only radical treatment available for patients with end-stage heart failure that is refractory to optimal medical treatment and device therapies. However, HT as a therapeutic o...Inflammation and Regeneration 2020 40:1Clinical application of injectable growth factor for bone regeneration: a systematic review
Bone regeneration has been the ultimate goal in the field of bone and joint medicine and has been evaluated through various basic research studies to date. Translational research of regenerative medicine has f...Inflammation and Regeneration 2019 39:20Review: corneal endothelial cell derivation methods from ES/iPS cells
Globally, approximately 12.7 million people are awaiting a transplantation, while only 185,000 cases of corneal transplantation are performed in a year. Corneal endothelial dysfunction (bullous keratopathy) du...Inflammation and Regeneration 2019 39:19Mesenchymal stem cell therapies for liver cirrhosis: MSCs as “conducting cells” for improvement of liver fibrosis and regeneration
Mesenchymal stem cells (MSCs) can be cultured relatively easily and can be obtained not only from the bone marrow, but also from medical waste such as adipose tissue and umbilical cord tissue. Because of its l...Inflammation and Regeneration 2019 39:18Overview: an iPS cell stock at CiRA
Induced pluripotent stem cells (iPSCs) can be produced from various somatic cells and have the ability to differentiate into various cells and tissues of the body. Regenerative medicine using iPSCs is expected...Inflammation and Regeneration 2019 39:17Shear bioreactors stimulating chondrocyte regeneration, a systematic review
It is commonly accepted that the mechanical stimuli are important factors in the maintenance of normal structure and function of the articular cartilage. Despite extensive efforts, the cellular mechanisms unde...Inflammation and Regeneration 2019 39:16- Inflammation and Regeneration 2019 39:15
The application of convolutional neural network to stem cell biology
Induced pluripotent stem cells (iPSC) are one the most prominent innovations of medical research in the last few decades. iPSCs can be easily generated from human somatic cells and have several potential uses ...Inflammation and Regeneration 2019 39:14Generation of functional human hepatocytes in vitro: current status and future prospects
Liver and hepatocyte transplantation are the only effective therapies for late-stage liver diseases, in which the liver loses its regenerative capacity. However, there is a shortage of donors. As a potential a...Inflammation and Regeneration 2019 39:13The role of interleukin-1 in general pathology
Interleukin-1, an inflammatory cytokine, is considered to have diverse physiological functions and pathological significances and play an important role in health and disease. In this decade, interleukin-1 fam...Inflammation and Regeneration 2019 39:12Chimeric antigen receptor T cell therapy for multiple myeloma
Chimeric antigen receptor (CAR) T cell therapy is a new cancer immunotherapy targeting cancer-specific cell surface antigen. CD19-CAR T cells have been already shown to be very effective to B cell leukemia/lym...Inflammation and Regeneration 2019 39:10Induced pluripotent stem cells representing Nakajo-Nishimura syndrome
Nakajo-Nishimura syndrome is a proteasome-associated autoinflammatory syndrome with a distinct homozygous mutation in the PSMB8 gene encoding an inducible β5i subunit of the immunoproteasome. Although it is consi...Inflammation and Regeneration 2019 39:11Isolation of tissue-resident endothelial stem cells and their use in regenerative medicine
During sprouting angiogenesis, stalk cells, localized behind tip cells, generate endothelial cells (ECs) for the elongation of new vessels. We hypothesized that stalk cells may have endothelial progenitor cell...Inflammation and Regeneration 2019 39:9Age-related dysfunction of the DNA damage response in intestinal stem cells
Senescence increases the risks of inflammatory bowel diseases and colon cancer. Intestinal stem cells (ISCs) in crypts differentiate into epithelial cells and thereby maintain intestinal homeostasis. However, ...Inflammation and Regeneration 2019 39:8Calendula officinalis stimulate proliferation of mouse embryonic fibroblasts via expression of growth factors TGFβ1 and bFGF
TGF-β has an important role in the process of wound healing and scar formation. The aim of this study is to determine the effects of ethanolic and methanolic extracts of Calendula officinalis on the expression of...Inflammation and Regeneration 2019 39:7T cell receptor signaling for γδT cell development
T cells are central to the vertebrate immune system. Two distinct types of T cells, αβT and γδT cells, express different types of T cell antigen receptors (TCRs), αβTCR and γδTCR, respectively, that are compos...Inflammation and Regeneration 2019 39:6Demographics and clinical characteristics associated with sustained remission and continuation of sustained remission in patients with rheumatoid arthritis treated with adalimumab
Tumor necrosis factor inhibitor therapy for rheumatoid arthritis (RA) patients reduces disease activity, but little is known about the factors that correlate with continuation of remission. To identify demogra...Inflammation and Regeneration 2019 39:5Use of human intra-tissue stem/progenitor cells and induced pluripotent stem cells for hair follicle regeneration
The hair follicle (HF) is a unique miniorgan, which self-renews for a lifetime. Stem cell populations of multiple lineages reside within human HF and enable its regeneration. In addition to resident HF stem/pr...Inflammation and Regeneration 2019 39:4Mechanical regulation of macrophage function - cyclic tensile force inhibits NLRP3 inflammasome-dependent IL-1β secretion in murine macrophages
Mechanical stress maintains tissue homeostasis by regulating many cellular functions including cell proliferation, differentiation, and inflammation and immune responses. In inflammatory microenvironments, mac...Inflammation and Regeneration 2019 39:3Encapsulation of Satureja khuzistanica extract in alginate hydrogel accelerate wound healing in adult male rats
Finding the best dressing for a specific wound had continued from the past to present. The aim of this study was to evaluate the effect of encapsulated extract of Satureja khuzistanica in hydrogel alginate at wou...Inflammation and Regeneration 2019 39:2Correction to: Roles of nitric oxide and ethyl pyruvate after peripheral nerve injury
After publication of the original article [1], it came to our attention that Professor Junyang Jung was omitted from the authorship.Inflammation and Regeneration 2019 39:1The original article was published in Inflammation and Regeneration 2017 37:20The impact of senescence-associated T cells on immunosenescence and age-related disorders
Immunosenescence is age-associated changes in the immunological functions, including diminished acquired immunity against infection, pro-inflammatory traits, and increased risk of autoimmunity. The proportions...Inflammation and Regeneration 2018 38:24Relationship between periodontal disease and butyric acid produced by periodontopathic bacteria
Periodontopathic bacteria such as Porphyromonas gingivalis produce a large amount of butyric acid as a metabolite. Though butyric acid has been reported to have an anti-inflammatory effect on inflammatory disease...Inflammation and Regeneration 2018 38:23Molecular mechanisms regulating lifespan and environmental stress responses
Throughout life, organisms are subjected to a variety of environmental perturbations, including temperature, nutrient conditions, and chemical agents. Exposure to external signals induces diverse changes in th...Inflammation and Regeneration 2018 38:22Phospholipase A2 in skin biology: new insights from gene-manipulated mice and lipidomics
The skin represents one of the tissues that are most profoundly influenced by alterations in the quality of lipids (lipoquality). Lipids not only constitute cellular membranes, but also serve as bioactive lipi...Inflammation and Regeneration 2018 38:31MHC-identical and transgenic cynomolgus macaques for preclinical studies
Cynomolgus macaques are useful experimental animals that are physiologically and genetically close to humans. We have developed two kinds of experimental usage of cynomolgus macaque: transplantation and diseas...Inflammation and Regeneration 2018 38:30Successful rituximab treatment of granulomatosis with polyangiitis with cranial neuropathies
In granulomatosis with polyangiitis (GPA), peripheral nerve involvement is common but central nervous system (CNS) involvement is extremely rare and treatment strategy has not been established. We report a cas...Inflammation and Regeneration 2018 38:20Amyloid β directly interacts with NLRP3 to initiate inflammasome activation: identification of an intrinsic NLRP3 ligand in a cell-free system
Alzheimer’s disease is a neurodegenerative disease characterized by the interstitial deposition of amyloid β (Aβ) plaque, which is thought to be related to chronic neuroinflammation. Aβ is known to make fibril...Inflammation and Regeneration 2018 38:27Transcriptome analysis of peripheral blood from patients with rheumatoid arthritis: a systematic review
In the era of precision medicine, transcriptome analysis of whole gene expression is an essential technology. While DNA microarray has a limited dynamic range and a problem of background hybridization, RNA seq...Inflammation and Regeneration 2018 38:21Biological functions of 12(S)-hydroxyheptadecatrienoic acid as a ligand of leukotriene B4 receptor 2
Although 12(S)-hydroxyheptadecatrienoic acid (12-HHT) is an abundant fatty acid, it is long considered a byproduct of thromboxane A2 production. We identified a leukotriene B4 receptor 2 (BLT2)-specific agonistic...Inflammation and Regeneration 2018 38:29PINK1-PARK2-mediated mitophagy in COPD and IPF pathogeneses
Mitochondria regulate not only cell functions through energy generation but also aging-associated cell phenotypes. Impaired mitochondrial structural and functional integrity accompanied by excessive mitochondr...Inflammation and Regeneration 2018 38:18Human iPS cell-engineered three-dimensional cardiac tissues perfused by capillary networks between host and graft
Stem cell-based cardiac regenerative therapy is expected to be a promising strategy for the treatment of severe heart diseases. Pluripotent stem cells enabled us to reconstruct regenerated myocardium in injure...Inflammation and Regeneration 2018 38:26Considerations in hiPSC-derived cartilage for articular cartilage repair
A lack of cell or tissue sources hampers regenerative medicine for articular cartilage damage.Inflammation and Regeneration 2018 38:17
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