martes, 18 de agosto de 2020

Journal of Experimental & Clinical Cancer Research | Articles

Journal of Experimental & Clinical Cancer Research | Articles

  • New Content Item
  • Owned by the Association for International Promotion & Study in Tumors (APSIT)
  • Regina Elena NCI
  • Official journal of the Regina Elena National Cancer Institute, Scientific Director Gennaro Ciliberto, Rome, Italy


  1. Pancreatic cancer (PC) is one of the most aggressive cancers and has an extremely poor prognosis worldwide. Long noncoding RNA (lncRNA) has been reported to be a potential prognostic biomarker in the initiatio...
    Authors:Qing Han, Junhe Li, Jianping Xiong and Zhiwang Song
    Citation:Journal of Experimental & Clinical Cancer Research 2020 39:151
    Content type:Research
     
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  2. Hepatocellular carcinoma (HCC) is one of the most prevalent common cancer worldwide with high mortality. Transforming growth factor-β (TGF-β) signaling pathway was reported dysregulated during liver cancer for...
    Authors:Zhao Huang, Jingyuan Wen, Jingjing Yu, Jingyu Liao, Sha Liu, Ning Cai, Huifang Liang, Xiaoping Chen, Zeyang Ding and Bixiang Zhang
    Citation:Journal of Experimental & Clinical Cancer Research 2020 39:150
    Content type:Research
     
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  3. Non-small cell lung cancer (NSCLC) cells derived intracellular and extracellular programmed cell death ligand 1 (PD-L1) promoted cancer progression and drug resistance, and facilitated tumor immune evasion. Ho...
    Authors:Weijun Hong, Min Xue, Jun Jiang, Yajuan Zhang and Xiwen Gao
    Citation:Journal of Experimental & Clinical Cancer Research 2020 39:149
    Content type:Research
     
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  4. Collagens are the most abundant proteins in extra cellular matrix and important components of tumor microenvironment. Recent studies have showed that aberrant expression of collagens can influence tumor cell b...
    Authors:Ting Wang, Haojie Jin, Jingying Hu, Xi Li, Haoyu Ruan, Huili Xu, Lin Wei, Weihua Dong, Fei Teng, Jianren Gu, Wenxin Qin, Xiaoying Luo and Yujun Hao
    Citation:Journal of Experimental & Clinical Cancer Research 2020 39:148
    Content type:Research
     
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  5. Colorectal cancer (CRC) is one of the most common malignancies, and it’s expected that the CRC burden will substantially increase in the next two decades. New biomarkers for targeted treatment and associated m...
    Authors:Xiaojuan Wang, Fan Wu, Han Wang, Xiaoyuan Duan, Rong Huang, Amannisa Tuersuntuoheti, Luying Su, Shida Yan, Yuechao Zhao, Yan Lu, Kai Li, Jinjie Yao, Zhiwen Luo, Lei Guo, Jianmei Liu, Xiao Chen…
    Citation:Journal of Experimental & Clinical Cancer Research 2020 39:147
    Content type:Research
     
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  6. The signal transducer and activator of transcription-3 (STAT-3) can facilitate cancer progression and metastasis by being constitutively active via various signaling. Abundant evidence has indicated that STAT-...
    Authors:Ming Hong, Selena Lee, Jacob Clayton, Wildman Yake and Jinke Li
    Citation:Journal of Experimental & Clinical Cancer Research 2020 39:146
    Content type:Research
     
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  7. Mounting evidence suggests that solid tumors display the features of collective invasion, however, the molecular mechanisms are far from clear. This study aims to verify the role and the underlying mechanisms ...
    Authors:Shi-Jie Wang, Dong Chao, Wei Wei, Gang Nan, Jia-Yue Li, Fen-Ling Liu, Ling Li, Jian-Li Jiang, Hong-Yong Cui and Zhi-Nan Chen
    Citation:Journal of Experimental & Clinical Cancer Research 2020 39:145
    Content type:Research
     
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  8. Esophageal squamous cell carcinoma (ESCC) is one of the most lethal forms of adult cancer with poor prognosis. Substantial evidence indicates that reactive oxygen species (ROS) are important modulators of aggr...
    Authors:Zhenchuan Liu, Shaorui Gu, Tiancheng Lu, Kaiqing Wu, Lei Li, Chenglai Dong and Yongxin Zhou
    Citation:Journal of Experimental & Clinical Cancer Research 2020 39:144
    Content type:Research
     
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  9. Cervical cancer is one of the most common cancers among females worldwide and advanced patients have extremely poor prognosis. However, adverse reactions and accumulating resistance to radiation therapy requir...
    Authors:Shuzhen Tian, Lili Lou, Mengyuan Tian, Guangping Lu, Jianghua Tian and Xi Chen
    Citation:Journal of Experimental & Clinical Cancer Research 2020 39:143
    Content type:Research
     
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  10. Sirtuin 6 (Sirt6) is a highly conserved ADP-ribosylase and NAD+ dependent deacylase, involved in broad cellular processes. This molecule possesses contradictory roles in carcinogenesis, as it has been document...
    Authors:Juan Yang, Ying Li, Ya Zhang, Xiaosheng Fang, Na Chen, Xiangxiang Zhou and Xin Wang
    Citation:Journal of Experimental & Clinical Cancer Research 2020 39:142
    Content type:Research
     
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  11. Long non-coding RNA H19 was demonstrated to be significantly correlated with tumor metastasis. However, the specific functions of H19 in colorectal cancer (CRC) metastasis and the underlying mechanism are stil...
    Authors:Yuhui Zhang, Weibin Huang, Yujie Yuan, Jin Li, Jing Wu, Jie Yu, Yulong He, Zhewei Wei and Changhua Zhang
    Citation:Journal of Experimental & Clinical Cancer Research 2020 39:141
    Content type:Research
     
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  12. Exosomal microRNAs (miRNAs or miRs) from bone marrow-derived mesenchymal stem cells (UCMSCs) have emerged as promising therapeutic strategies for cancer treatment. The current study aimed to elucidate the unde...
    Authors:Zhanfeng He, Weihao Li, Tianliang Zheng, Donglei Liu and Song Zhao
    Citation:Journal of Experimental & Clinical Cancer Research 2020 39:140
    Content type:Research
     
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  13. Long noncoding RNAs (lncRNAs) are considered critical regulators in cancers; however, the clinical significance and mechanisms of MAPKAPK5-AS1 (hereinafter referred to as MK5-AS1) in colorectal cancer (CRC) re...
    Authors:Ting Yang, Wei-Cong Chen, Pei-Cong Shi, Man-Ru Liu, Tao Jiang, Hu Song, Jia-Qi Wang, Rui-Zhi Fan, Dong-Sheng Pei and Jun Song
    Citation:Journal of Experimental & Clinical Cancer Research 2020 39:139
    Content type:Research
     
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  14. The epigenetic abnormality is generally accepted as the key to cancer initiation. Epigenetics that ensure the somatic inheritance of differentiated state is defined as a crucial factor influencing malignant ph...
    Authors:Rui Chen, Mengxian Zhang, Yangmei Zhou, Wenjing Guo, Ming Yi, Ziyan Zhang, Yanpeng Ding and Yali Wang
    Citation:Journal of Experimental & Clinical Cancer Research 2020 39:138
    Content type:Review
     
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  15. Hypoxia, a fundamental characteristic of glioma, is considered to promote tumor malignancy by inducing process of epithelial mesenchymal transition (EMT). Ferritin Light Chain (FTL) is one of the iron metaboli...
    Authors:Junhui Liu, Lun Gao, Na Zhan, Pengfei Xu, Ji’an Yang, Fan’en Yuan, Yang Xu, Qiang Cai, Rongxin Geng and Qianxue Chen
    Citation:Journal of Experimental & Clinical Cancer Research 2020 39:137
    Content type:Research
     
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  16. Accumulating evidence have highlighted the importance of long noncoding RNAs (lncRNAs) in multiple cancers development and progression. Cancer susceptibility candidate 9 (CASC9) is a novel long non-coding RNA ...
    Authors:Yonghao Zhan, Lianghao Zhang, Shuanbao Yu, Jianguo Wen, Yuchen Liu and Xuepei Zhang
    Citation:Journal of Experimental & Clinical Cancer Research 2020 39:136
    Content type:Research
     
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  17. Hepatocellular carcinoma (HCC) is one of the most common malignant cancers with poor prognosis and high incidence. The clinical data analysis of liver hepatocellular carcinoma samples downloaded from The Cance...
    Authors:Shijiao Cai, Yunpeng Bai, Huan Wang, Zihan Zhao, Xiujuan Ding, Heng Zhang, Xiaoyun Zhang, Yantao Liu, Yan Jia, Yinan Li, Shuang Chen, Honggang Zhou, Huijuan Liu, Cheng Yang and Tao Sun
    Citation:Journal of Experimental & Clinical Cancer Research 2020 39:135
    Content type:Research
     
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  18. Transfer of noncoding microRNAs (miRNAs) by extracellular vesicles (EVs) promotes the development of chemoresistance in many tumor types. Additionally, restoration or depletion of several miRNAs has been obser...
    Authors:Yu Zhang, Wenbo Meng, Ping Yue and Xun Li
    Citation:Journal of Experimental & Clinical Cancer Research 2020 39:134
    Content type:Research
     
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  19. Esophageal squamous cell carcinoma (ESCC) is one of the most prevalent gastrointestinal malignancies with high mortality. Circular RNAs (CircRNAs) have become a research hotspot in recent years for their vital...
    Authors:Xiaoqi Chen, Jing Jiang, Yunxia Zhao, Xinting Wang, Chuanlei Zhang, Lv Zhuan, Danyang Zhang and Yuling Zheng
    Citation:Journal of Experimental & Clinical Cancer Research 2020 39:133
    Content type:Research
     
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  20. Crosstalk between cancer cells and tumor-associated macrophages (TAMs) mediates tumor progression in colorectal cancer (CRC). Cytoplasmic polyadenylation element binding protein 3 (CPEB3) has been shown to exh...
    Authors:Qian Zhong, Yuxin Fang, Qiuhua Lai, Shanci Wang, Chengcheng He, Aimin Li, Side Liu and Qun Yan
    Citation:Journal of Experimental & Clinical Cancer Research 2020 39:132
    Content type:Research
     
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  21. Esophageal cancer (EC) represents one of the most aggressive digestive neoplasms globally, with marked geographical variations in morbidity and mortality. Chemoprevention is a promising approach for cancer the...
    Authors:Shuyao Zhang, Fuchun Zheng, Liqun Zhang, Zuojun Huang, Xiaoshan Huang, Zhen Pan, Shuang Chen, Chenchen Xu, Yi Jiang, Shuyi Gu, Chengkuan Zhao, Qiuzhen Zhang and Ganggang Shi
    Citation:Journal of Experimental & Clinical Cancer Research 2020 39:131
    Content type:Research
     
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  22. An amendment to this paper has been published and can be accessed via the original article.
    Authors:Yujun Tang, Yishi Lu, Yuan Cheng, Lei Luo, Lei Cai, Bangjian Peng, Wenbin Huang, Hangyu Liao, Liang Zhao and Mingxin Pan
    Citation:Journal of Experimental & Clinical Cancer Research 2020 39:130
    Content type:Correction
     
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    The original article was published in Journal of Experimental & Clinical Cancer Research 2019 38:473

  23. Radiotherapy is the cornerstone of treatment of high-grade gliomas (HGGs). It eradicates tumor cells by inducing oxidative stress and subsequent DNA damage. Unfortunately, almost all HGGs recur locally within ...
    Authors:Han Shen, Kristina Cook, Harriet E. Gee and Eric Hau
    Citation:Journal of Experimental & Clinical Cancer Research 2020 39:129
    Content type:Review
     
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  24. Hepatocellular carcinoma is the third top cause of cancer-related mortalities worldwide. The prognosis of HCC patients remains poor due to rapid progression and high incidence of tumor recurrence. Nicastrin (N...
    Authors:Hui Li, Tian Lan, Lin Xu, Hailing Liu, Jinju Wang, Jiaxin Li, Xiangzheng Chen, Jiwei Huang, Xuefeng Li, Kefei Yuan, Yong Zeng and Hong Wu
    Citation:Journal of Experimental & Clinical Cancer Research 2020 39:128
    Content type:Research
     
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  25. Recent studies have shown that the classic hypoglycemic drug metformin inhibits tumor growth; however, the underlying mechanism remains unclear. We previously showed that metformin disrupts the sponge effect o...
    Authors:Chenglai Xia, Chang Liu, Zhihong He, Yantao Cai and Jinman Chen
    Citation:Journal of Experimental & Clinical Cancer Research 2020 39:127
    Content type:Research
     
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  26. Liver cancer has become the sixth most diagnosed cancer and the fourth leading cause of cancer death worldwide. Hepatocellular carcinoma (HCC) is responsible for up to 75–85% of primary liver cancers, and sora...
    Authors:Jiao Feng, Jingjing Li, Liwei Wu, Qiang Yu, Jie Ji, Jianye Wu, Weiqi Dai and Chuanyong Guo
    Citation:Journal of Experimental & Clinical Cancer Research 2020 39:126
    Content type:Review
     
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  27. An amendment to this paper has been published and can be accessed via the original article.
    Authors:Zhiyan Hu, Ting Long, Yidan Ma, Jiaxian Zhu, Lingfang Gao, Yan Zhong, Xia Wang, Xiaoyan Wang and Zuguo Li
    Citation:Journal of Experimental & Clinical Cancer Research 2020 39:125
    Content type:Correction
     
    Published on: 
    The original article was published in Journal of Experimental & Clinical Cancer Research 2020 39:76

  28. Malformation of blood vessels represents a hallmark of cancers, but the role and regulation of vascular mural cells (vMCs), including vascular smooth muscle cells (vSMCs) and pericytes, in tumors has not been ...
    Authors:Xinxin Zhang, Xianchun Yan, Jing Cao, Ziyan Yang, Xiuli Cao, Yufei Zhang, Liang Liang, Minhua Zheng, Xiaowei Liu, Jian Zhang and Hua Han
    Citation:Journal of Experimental & Clinical Cancer Research 2020 39:124
    Content type:Research
     
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  29. 3-Hydroxy butyrate dehydrogenase 2 (BDH2) is a short-chain dehydrogenase/reductase family member that plays a key role in the development and pathogenesis of human cancers. However, the role of BDH2 in gastric...
    Authors:Jia-Zhou Liu, Yi-Lin Hu, Ying Feng, Yun Jiang, Yi-Bing Guo, Yi-Fei Liu, Xi Chen, Jun-Ling Yang, Yu-yan Chen, Qin-Sheng Mao and Wan-Jiang Xue
    Citation:Journal of Experimental & Clinical Cancer Research 2020 39:123
    Content type:Research
     
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  30. Tumor progression and tumor response to anticancer therapies may be affected by activation of oncogenic pathways such as the antioxidant one induced by NRF2 (nuclear factor erythroid 2-related factor 2) transc...
    Authors:Alessia Garufi, Silvia Baldari, Riccardo Pettinari, Maria Saveria Gilardini Montani, Valerio D’Orazi, Giuseppa Pistritto, Alessandra Crispini, Eugenia Giorno, Gabriele Toietta, Fabio Marchetti, Mara Cirone and Gabriella D’Orazi
    Citation:Journal of Experimental & Clinical Cancer Research 2020 39:122
    Content type:Research
     
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  31. Angiogenesis plays an important role in the progress of glioma. RNA-binding proteins (RBPs) and circular RNAs (circRNAs), dysregulated in various tumors, have been verified to mediate diverse biological behavi...
    Authors:Xiaobai Liu, Shuyuan Shen, Lu Zhu, Rui Su, Jian Zheng, Xuelei Ruan, Lianqi Shao, Di Wang, Chunqing Yang and Yunhui Liu
    Citation:Journal of Experimental & Clinical Cancer Research 2020 39:121
    Content type:Research
     
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  32. An amendment to this paper has been published and can be accessed via the original article.
    Authors:Marco Russano, Andrea Napolitano, Giulia Ribelli, Michele Iuliani, Sonia Simonetti, Fabrizio Citarella, Francesco Pantano, Emanuela Dell’Aquila, Cecilia Anesi, Nicola Silvestris, Antonella Argentiero, Antonio Giovanni Solimando, Bruno Vincenzi, Giuseppe Tonini and Daniele Santini
    Citation:Journal of Experimental & Clinical Cancer Research 2020 39:120
    Content type:Correction
     
    Published on: 
    The original article was published in Journal of Experimental & Clinical Cancer Research 2020 39:95

  33. Gastric cancer (GC) is a common form of malignant cancer in worldwide which has a poor prognosis. Despite recent improvements in the treatment of GC, the prognosis is not yet satisfactory for GC patients. CYT997,...
    Authors:Ya Cao, Jinglong Wang, Hua Tian and Guo-Hui Fu
    Citation:Journal of Experimental & Clinical Cancer Research 2020 39:119
    Content type:Research
     
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  34. Gastric cancer (GC) is the most prevalent gastrointestinal tumor with an unfavorable clinical prognosis. GC patients are largely threatened owing to metastasis and drug resistance. Tumor angiogenesis plays an ...
    Authors:Jun-Jie Chen, Yan-Lin Ren, Chuan-Jun Shu, Yi Zhang, Min-Juan Chen, Jin Xu, Jin Li, Ai-Ping Li, Dong-Yin Chen, Jing-Dong He, Yong-Qian Shu and Jian-Wei Zhou
    Citation:Journal of Experimental & Clinical Cancer Research 2020 39:118
    Content type:Research
     
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  35. The discovery of the role of non-coding RNAs (ncRNAs) in the onset and progression of malignancies is a promising frontier of cancer genetics. It is clear that ncRNAs are candidates for therapeutic interventio...
    Authors:Katia Grillone, Caterina Riillo, Francesca Scionti, Roberta Rocca, Giuseppe Tradigo, Pietro Hiram Guzzi, Stefano Alcaro, Maria Teresa Di Martino, Pierosandro Tagliaferri and Pierfrancesco Tassone
    Citation:Journal of Experimental & Clinical Cancer Research 2020 39:117
    Content type:Review
     
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  36. Aberrant alternative splicing events play critical roles in carcinogenesis and progression of many cancers, while sparse studies regarding to alternative splicing are available for clear cell renal cell carcin...
    Authors:Guoliang Sun, Hui Zhou, Ke Chen, Jin Zeng, Yangjun Zhang, Libin Yan, Weimin Yao, Junhui Hu, Tao Wang, Jinchun Xing, Kefeng Xiao, Lily Wu, Zhangqun Ye and Hua Xu
    Citation:Journal of Experimental & Clinical Cancer Research 2020 39:116
    Content type:Research
     
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  37. An amendment to this paper has been published and can be accessed via the original article.
    Authors:Jing Zhang, Xiao-han Liu, Cong Li, Xiao-xing Wu, Yan-lin Chen, Wen-wen Li, Xian Li, Fan Gong, Qin Tang and Dan Jiang
    Citation:Journal of Experimental & Clinical Cancer Research 2020 39:115
    Content type:Correction
     
    Published on: 
    The original article was published in Journal of Experimental & Clinical Cancer Research 2020 39:79

  38. Circular RNAs (circRNAs) play a critical regulatory role in cancer progression. However, the underlying mechanisms of circRNAs in hepatocellular carcinoma (HCC) metastasis remain mostly unknown.
    Authors:Li-na Song, Guang-lei Qiao, Jian Yu, Chun-mei Yang, Ying Chen, Zhou-feng Deng, Li-hua Song, Li-jun Ma and Hong-li Yan
    Citation:Journal of Experimental & Clinical Cancer Research 2020 39:114
    Content type:Research
     
    Published on: 
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