viernes, 7 de agosto de 2020

Reviews from journal of experimental & clinical cancer research

Reviews from journal of experimental & clinical cancer research

  • Owned by the Association for International Promotion & Study in Tumors (APSIT)
  • Official journal of the Regina Elena National Cancer Institute, Scientific Director Gennaro Ciliberto, Rome, Italy


Reviews from Journal of Experimental & Clinical Cancer Research

Below is a summary of all reviews published in JECCR
Page 1 of 4
  1. Liver cancer has become the sixth most diagnosed cancer and the fourth leading cause of cancer death worldwide. Hepatocellular carcinoma (HCC) is responsible for up to 75–85% of primary liver cancers, and sora...
    Authors:Jiao Feng, Jingjing Li, Liwei Wu, Qiang Yu, Jie Ji, Jianye Wu, Weiqi Dai and Chuanyong Guo
    Citation:Journal of Experimental & Clinical Cancer Research 2020 39:126
    Content type:Review
     
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  2. The discovery of the role of non-coding RNAs (ncRNAs) in the onset and progression of malignancies is a promising frontier of cancer genetics. It is clear that ncRNAs are candidates for therapeutic interventio...
    Authors:Katia Grillone, Caterina Riillo, Francesca Scionti, Roberta Rocca, Giuseppe Tradigo, Pietro Hiram Guzzi, Stefano Alcaro, Maria Teresa Di Martino, Pierosandro Tagliaferri and Pierfrancesco Tassone
    Citation:Journal of Experimental & Clinical Cancer Research 2020 39:117
    Content type:Review
     
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  3. Hypoxia-induced alternative splicing is a potent driving force in tumour pathogenesis and progression. In this review, we update currents concepts of hypoxia-induced alternative splicing and how it influences ...
    Authors:Antonietta Rosella Farina, Lucia Cappabianca, Michela Sebastiano, Veronica Zelli, Stefano Guadagni and Andrew Reay Mackay
    Citation:Journal of Experimental & Clinical Cancer Research 2020 39:110
    Content type:Review
     
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  4. Human pluripotent embryonic stem cells have two special features: self-renewal and pluripotency. It is important to understand the properties of pluripotent stem cells and reprogrammed stem cells. One of the m...
    Authors:Kenly Wuputra, Chia-Chen Ku, Deng-Chyang Wu, Ying-Chu Lin, Shigeo Saito and Kazunari K. Yokoyama
    Citation:Journal of Experimental & Clinical Cancer Research 2020 39:100
    Content type:Review
     
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  5. Hepatocellular carcinoma (HCC) is one of the most common malignancies today. Patients suffer from HCC since its high malignancy and limited treatment means. With the development of genetic research, new therap...
    Authors:Xiaoling Wu, Weijie Ma, Chengjie Mei, Xi Chen, Ye Yao, Yingyi Liu, Xian Qin and Yufeng Yuan
    Citation:Journal of Experimental & Clinical Cancer Research 2020 39:97
    Content type:Review
     
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  6. In a large number of cancer types, treatment selection depends on the presence of specific tumor biomarkers. Due to the dynamic nature of cancer, very often these predictive biomarkers are not uniformly presen...
    Authors:Marco Russano, Andrea Napolitano, Giulia Ribelli, Michele Iuliani, Sonia Simonetti, Fabrizio Citarella, Francesco Pantano, Emanuela Dell’Aquila, Cecilia Anesi, Nicola Silvestris, Antonella Argentiero, Antonio Giovanni Solimando, Bruno Vincenzi, Giuseppe Tonini and Daniele Santini
    Citation:Journal of Experimental & Clinical Cancer Research 2020 39:95
    Content type:Review
     
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    The Correction to this article has been published in Journal of Experimental & Clinical Cancer Research 2020 39:120
  7. Tumor-infiltrating immune cells play a key role against cancer. However, malignant cells are able to evade the immune response and establish a very complex balance in which different immune subtypes may drive ...
    Authors:Filippo Galli, Jesus Vera Aguilera, Belinda Palermo, Svetomir N. Markovic, Paola Nisticò and Alberto Signore
    Citation:Journal of Experimental & Clinical Cancer Research 2020 39:89
    Content type:Review
     
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  8. The very limited time allowed to face the COVID-19 pandemic poses a pressing challenge to find proper therapeutic approaches. However, synthesis and full investigation from preclinical studies to phase III tri...
    Authors:Gennaro Ciliberto, Rita Mancini and Marco G. Paggi
    Citation:Journal of Experimental & Clinical Cancer Research 2020 39:86
    Content type:Review
     
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  9. The majority of high-risk neuroblastomas can be divided into three distinct molecular subgroups defined by the presence of MYCN amplification, upstream TERT rearrangements or alternative lengthening of telomeres ...
    Authors:S. L. George, V. Parmar, F. Lorenzi, L. V. Marshall, Y. Jamin, E. Poon, P. Angelini and L. Chesler
    Citation:Journal of Experimental & Clinical Cancer Research 2020 39:78
    Content type:Review
     
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  10. The heterogeneous tumor microenvironment (TME) is highly complex and not entirely understood. These complex configurations lead to the generation of oxygen-deprived conditions within the tumor niche, which mod...
    Authors:Somshuvra Bhattacharya, Kristin Calar and Pilar de la Puente
    Citation:Journal of Experimental & Clinical Cancer Research 2020 39:75
    Content type:Review
     
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  11. Tumor microenvironment (TME) is the internal environment in which tumor cells survive, consisting of tumor cells, fibroblasts, endothelial cells, and immune cells, as well as non-cellular components, such as e...
    Authors:Shiming Tan, Longzheng Xia, Pin Yi, Yaqian Han, Lu Tang, Qing Pan, Yutong Tian, Shan Rao, Linda Oyang, Jiaxin Liang, Jinguan Lin, Min Su, Yingrui Shi, Deliang Cao, Yujuan Zhou and Qianjin Liao
    Citation:Journal of Experimental & Clinical Cancer Research 2020 39:67
    Content type:Review
     
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  12. In-depth analysis of global RNA sequencing has enabled a comprehensive overview of cellular transcriptomes and revealed the pervasive transcription of divergent RNAs from promoter regions across eukaryotic gen...
    Authors:Lidia Chellini, Valentina Frezza and Maria Paola Paronetto
    Citation:Journal of Experimental & Clinical Cancer Research 2020 39:51
    Content type:Review
     
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  13. The promising expectations about personalized medicine have opened the path to routine large-scale sequencing and increased the importance of genetic counseling for hereditary cancers, among which hereditary b...
    Authors:Giulia Federici and Silvia Soddu
    Citation:Journal of Experimental & Clinical Cancer Research 2020 39:46
    Content type:Review
     
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  14. Hypoxia is a classic characteristic of the tumor microenvironment with a significant impact on cancer progression and therapeutic response. Hypoxia-inducible factor-1 alpha (HIF-1α), the most important transcr...
    Authors:Xiafeng Peng, Han Gao, Rui Xu, Huiyu Wang, Jie Mei and Chaoying Liu
    Citation:Journal of Experimental & Clinical Cancer Research 2020 39:27
    Content type:Review
     
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    The Correction to this article has been published in Journal of Experimental & Clinical Cancer Research 2020 39:45
  15. Growing evidence showed the increased prevalence of cancer incidents, particularly colorectal cancer, among type 2 diabetic mellitus patients. Antidiabetic medications such as, insulin, sulfonylureas, dipeptyl...
    Authors:Muhamad Noor Alfarizal Kamarudin, Md. Moklesur Rahman Sarker, Jin-Rong Zhou and Ishwar Parhar
    Citation:Journal of Experimental & Clinical Cancer Research 2019 38:491
    Content type:Review
     
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  16. Molecular targeted therapy for advanced hepatocellular carcinoma (HCC) has changed markedly. Although sorafenib was used in clinical practice as the first molecular targeted agent in 2007, the SHARPE and Asian...
    Authors:Ziyu Liu, Yan Lin, Jinyan Zhang, Yumei Zhang, Yongqiang Li, Zhihui Liu, Qian Li, Ming Luo, Rong Liang and Jiazhou Ye
    Citation:Journal of Experimental & Clinical Cancer Research 2019 38:447
    Content type:Review
     
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  17. The monocyte chemoattractant protein-induced protein (MCPIP) family consists of 4 members (MCPIP1–4) encoded by the ZC3h12A-D genes, which are located at different loci. The common features of MCPIP proteins are ...
    Authors:Katarzyna Miekus, Jerzy Kotlinowski, Agata Lichawska-Cieslar, Janusz Rys and Jolanta Jura
    Citation:Journal of Experimental & Clinical Cancer Research 2019 38:421
    Content type:Review
     
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  18. Until very few years ago, the oncology community dogmatically excluded any clinical potential for immunotherapy in controlling brain metastases. Therefore, despite the significant therapeutic efficacy of monoc...
    Authors:Anna Maria Di Giacomo, Monica Valente, Alfonso Cerase, Maria Fortunata Lofiego, Francesca Piazzini, Luana Calabrò, Elisabetta Gambale, Alessia Covre and Michele Maio
    Citation:Journal of Experimental & Clinical Cancer Research 2019 38:419
    Content type:Review
     
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  19. Iron, an indispensable element for life, is involved in all kinds of important physiological activities. Iron promotes cell growth and proliferation, but it also causes oxidative stress damage. The body has a ...
    Authors:Fang Wang, Huanhuan Lv, Bin Zhao, Liangfu Zhou, Shenghang Wang, Jie Luo, Junyu Liu and Peng Shang
    Citation:Journal of Experimental & Clinical Cancer Research 2019 38:406
    Content type:Review
     
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  20. T cells play important roles in anti-tumor immunity. Emerging evidence has revealed that distinct metabolic changes impact the activation and differentiation of T cells. Tailoring immune responses by manipulat...
    Authors:Zhongping Yin, Ling Bai, Wei Li, Tanlun Zeng, Huimin Tian and Jiuwei Cui
    Citation:Journal of Experimental & Clinical Cancer Research 2019 38:403
    Content type:Review
     
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  21. Hepatocellular carcinoma (HCC) ranks the most common primary liver malignancy and the third leading cause of tumor-related mortality worldwide. Unfortunately, despite advances in HCC treatment, less than 40% o...
    Authors:Yaojie Fu, Shanshan Liu, Shan Zeng and Hong Shen
    Citation:Journal of Experimental & Clinical Cancer Research 2019 38:396
    Content type:Review
     
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  22. Survivin (also named BIRC5) is a well-known cancer therapeutic target. Since its discovery more than two decades ago, the use of survivin as a target for cancer therapeutics has remained a central goal of surv...
    Authors:Fengzhi Li, Ieman Aljahdali and Xiang Ling
    Citation:Journal of Experimental & Clinical Cancer Research 2019 38:368
    Content type:Review
     
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  23. Tumor heterogeneity results in differential response to therapy due to the existence of plastic tumor cells, called cancer stem cells (CSCs), which exhibit the property of resistance to therapy, invasion and m...
    Authors:Pavana Thomas, Annapurna Pranatharthi, Cecil Ross and Sweta Srivastava
    Citation:Journal of Experimental & Clinical Cancer Research 2019 38:328
    Content type:Review
     
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  24. Malignant tumors are often multifactorial. Epidemiological studies have shown that hyperglycemia raises the prevalence and mortality of certain malignancies, like breast, liver, bladder, pancreatic, colorectal...
    Authors:Wenjie Li, Xuehui Zhang, Hui Sang, Ying Zhou, Chunyu Shang, Yongqing Wang and Hong Zhu
    Citation:Journal of Experimental & Clinical Cancer Research 2019 38:327
    Content type:Review
     
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  25. Numerous studies have presented that curcumin could have a positive effect in the prevention of cancer and then in tumor therapy. Several hypotheses have highlighted that curcumin could decreases tumor growth ...
    Authors:Alexandre Vallée, Yves Lecarpentier and Jean-Noël Vallée
    Citation:Journal of Experimental & Clinical Cancer Research 2019 38:323
    Content type:Review
     
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  26. Drug resistance represents the major reason of pharmacological treatment failure. It is supported by a broad spectrum of mechanisms, whose molecular bases have been frequently correlated to aberrant protein ph...
    Authors:Christian Borgo and Maria Ruzzene
    Citation:Journal of Experimental & Clinical Cancer Research 2019 38:287
    Content type:Review
     
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  27. Gliomas represent the most common type of malignant brain tumor, among which, glioblastoma remains a clinical challenge with limited treatment options and dismal prognosis. It has been shown that the dysregula...
    Authors:Fangling Cheng and Dongsheng Guo
    Citation:Journal of Experimental & Clinical Cancer Research 2019 38:270
    Content type:Review
     
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  28. Immunotherapy has become an established pillar of cancer treatment improving the prognosis of many patients with a broad variety of hematological and solid malignancies. The two main drivers behind this succes...
    Authors:Stephan Kruger, Matthias Ilmer, Sebastian Kobold, Bruno L. Cadilha, Stefan Endres, Steffen Ormanns, Gesa Schuebbe, Bernhard W. Renz, Jan G. D’Haese, Hans Schloesser, Volker Heinemann, Marion Subklewe, Stefan Boeck, Jens Werner and Michael von Bergwelt-Baildon
    Citation:Journal of Experimental & Clinical Cancer Research 2019 38:268
    Content type:Review
     
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  29. Autophagy is a catabolic process whose activation may help cancer cells to adapt to cellular stress although, in some instances, it can induce cell death. Autophagy stimulation or inhibition has been considere...
    Authors:Mara Cirone, Maria Saveria Gilardini Montani, Marisa Granato, Alessia Garufi, Alberto Faggioni and Gabriella D’Orazi
    Citation:Journal of Experimental & Clinical Cancer Research 2019 38:262
    Content type:Review
     
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  30. Targeting checkpoints of immune cell activation has been demonstrated to be the most effective approach for activation of anti-tumor immune responses. Cytotoxic T-lymphocyte-associated protein 4 (CTLA-4) and p...
    Authors:Anand Rotte
    Citation:Journal of Experimental & Clinical Cancer Research 2019 38:255
    Content type:Review
     
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  31. Because of the complexity of the blood-brain barrier (BBB), brain tumors, especially the most common and aggressive primary malignant tumor type arising from the central nervous system (CNS), glioblastoma, rem...
    Authors:George E. D. Petrescu, Alexandru A. Sabo, Ligia I. Torsin, George A. Calin and Mihnea P. Dragomir
    Citation:Journal of Experimental & Clinical Cancer Research 2019 38:231
    Content type:Review
     
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  32. Stromal stimuli mediated by growth factor receptors, leading to ligand-independent activation of steroid hormone receptors, have long been implicated in development of breast cancer resistance to endocrine the...
    Authors:Dominika Piasecka, Marcin Braun, Kamila Kitowska, Kamil Mieczkowski, Radzislaw Kordek, Rafal Sadej and Hanna Romanska
    Citation:Journal of Experimental & Clinical Cancer Research 2019 38:230
    Content type:Review
     
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  33. Reprogramming of cancer metabolism is a newly recognized hallmark of malignancy. The aberrant glucose metabolism is associated with dramatically increased bioenergetics, biosynthetic, and redox demands, which ...
    Authors:Jinguan Lin, Longzheng Xia, Jiaxin Liang, Yaqian Han, Heran Wang, Linda Oyang, Shiming Tan, Yutong Tian, Shan Rao, Xiaoyan Chen, Yanyan Tang, Min Su, Xia Luo, Ying Wang, Hui Wang, Yujuan Zhou…
    Citation:Journal of Experimental & Clinical Cancer Research 2019 38:218
    Content type:Review
     
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  34. Growing preclinical evidence shows that short-term fasting (STF) protects from toxicity while enhancing the efficacy of a variety of chemotherapeutic agents in the treatment of various tumour types. STF reinfo...
    Authors:Stefanie de Groot, Hanno Pijl, Jacobus J. M. van der Hoeven and Judith R. Kroep
    Citation:Journal of Experimental & Clinical Cancer Research 2019 38:209
    Content type:Review
     
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  35. Hepatocellular carcinoma (HCC) is one of the most notable lethal malignancies worldwide. However, the molecular mechanisms involved in the initiation and progression of this disease remain poorly understood. O...
    Authors:Haoming Mai, Bin Zhou, Li Liu, Fu Yang, Carly Conran, Yuan Ji, Jinlin Hou and Deke Jiang
    Citation:Journal of Experimental & Clinical Cancer Research 2019 38:198
    Content type:Review
     
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    The Correction to this article has been published in Journal of Experimental & Clinical Cancer Research 2019 38:352
  36. Triple negative breast cancer (TNBC), which is typically lack of expression of estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor receptor 2 (HER2), represents the most aggre...
    Authors:Jiang-Jiang Qin, Li Yan, Jia Zhang and Wei-Dong Zhang
    Citation:Journal of Experimental & Clinical Cancer Research 2019 38:195
    Content type:Review
     
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  37. Cancer-associated fibroblasts (CAFs) plays an essential role in cancer cell growth, metabolism and immunoreaction. Autophagy is an intracellular self-degradative process that balances cell energy source and re...
    Authors:Yuanliang Yan, Xi Chen, Xiang Wang, Zijin Zhao, Wenfeng Hu, Shuangshuang Zeng, Jie Wei, Xue Yang, Long Qian, Shuyi Zhou, Lunquan Sun, Zhicheng Gong and Zhijie Xu
    Citation:Journal of Experimental & Clinical Cancer Research 2019 38:171
    Content type:Review
     
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  38. Pancreatic cancer is one of the most lethal type of cancers, with an overall five-year survival rate of less than 5%. It is usually diagnosed at an advanced stage with limited therapeutic options. To date, no ...
    Authors:Chin-King Looi, Felicia Fei-Lei Chung, Chee-Onn Leong, Shew-Fung Wong, Rozita Rosli and Chun-Wai Mai
    Citation:Journal of Experimental & Clinical Cancer Research 2019 38:162
    Content type:Review
     
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  39. Cancer is currently the second leading cause of death globally and is expected to be responsible for approximately 9.6 million deaths in 2018. With an unprecedented understanding of the molecular pathways that...
    Authors:N. A. Seebacher, A. E. Stacy, G. M. Porter and A. M. Merlot
    Citation:Journal of Experimental & Clinical Cancer Research 2019 38:156
    Content type:Review
     
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  40. The recent developments in immuno-oncology have opened an unprecedented avenue for the emergence of vaccine strategies. Therapeutic DNA cancer vaccines are now considered a very promising strategy to activate ...
    Authors:Alessandra Lopes, Gaëlle Vandermeulen and Véronique Préat
    Citation:Journal of Experimental & Clinical Cancer Research 2019 38:146
    Content type:Review
     
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  41. Immune checkpoint inhibitor therapy has changed clinical practice for patients with different cancers, since these agents have demonstrated a significant improvement of overall survival and are effective in ma...
    Authors:Francesca Di Modugno, Cristina Colosi, Paola Trono, Giuseppe Antonacci, Giancarlo Ruocco and Paola Nisticò
    Citation:Journal of Experimental & Clinical Cancer Research 2019 38:117
    Content type:Review
     
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  42. The p38 mitogen-activated protein kinase (p38MAPK) pathway has been implicated in a variety of pathological conditions including inflammation and metastasis. Post-transcriptional regulation of genes harboring ...
    Authors:Sourabh Soni, Prince Anand and Yogendra S. Padwad
    Citation:Journal of Experimental & Clinical Cancer Research 2019 38:121
    Content type:Review
     
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  43. The extracellular matrix (ECM) plays an important role in cancer progression. It can be divided into the basement membrane (BM) that supports epithelial/endothelial cell behavior and the interstitial matrix (I...
    Authors:Neel I. Nissen, Morten Karsdal and Nicholas Willumsen
    Citation:Journal of Experimental & Clinical Cancer Research 2019 38:115
    Content type:Review
     
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  44. Novel therapeutic strategies are urgently needed for the treatment of metastatic Urothelial Bladder Cancer. DNA damaging repair (DDR) targeting has been introduced in cinical trials for bladder cancer patients...
    Authors:Daniela Criscuolo, Francesco Morra, Riccardo Giannella, Roberta Visconti, Aniello Cerrato and Angela Celetti
    Citation:Journal of Experimental & Clinical Cancer Research 2019 38:91
    Content type:Review
     
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  45. PD-1/PD-L1 checkpoint blockades have achieved significant progress in several kinds of tumours. Pembrolizumab, which targets PD-1, has been approved as a first-line treatment for advanced non-small cell lung c...
    Authors:Xin Wang, Gaochao Guo, Hui Guan, Yang Yu, Jie Lu and Jinming Yu
    Citation:Journal of Experimental & Clinical Cancer Research 2019 38:87
    Content type:Review
     
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