Opioid ▲ Public Health Genomics Knowledge Base (v1.0)

Public Health Genomics Knowledge Base (v1.0)










Last Updated: Apr 30, 2016

• Gender difference in prescription opioid abuse: A focus on oxycodone and hydrocodone.
  Graziani Manuela, et al. Pharmacological research 2016 4 31-38
• Nicotine-specific and non-specific effects of cigarette smoking on endogenous opioid mechanisms.
  Nuechterlein Emily B, et al. Progress in neuro-psychopharmacology & biological psychiatry 2016 4
• ADHD risk alleles associated with opiate addiction: study of addicted parents and their children.
  Ornoy Asher, et al. Pediatric research 2016 4
• The ABCB1, rs9282564, AG and TT Genotypes and the COMT, rs4680, AA Genotype are less frequent in Deceased Patients with Opioid Addiction (DOA) than in Living Patients with Opioid Addiction (LOA).
  Christoffersen Dorte J, et al. Basic & clinical pharmacology & toxicology 2016 4
• Association between Gene Polymorphisms and Pain Sensitivity Assessed in a Multi-Modal Multi-Tissue Human Experimental Model - An Explorative Study.
  Nielsen Lecia Møller, et al. Basic & clinical pharmacology & toxicology 2016 4
• "Weak" opioid analgesics. Codeine, dihydrocodeine and tramadol: no less risky than morphine.
  Prescrire international 2016 2 (168) 45-50
• Genome-Wide Pharmacogenomic Study on Methadone Maintenance Treatment Identifies SNP rs17180299 and Multiple Haplotypes on CYP2B6, SPON1, and GSG1L Associated with Plasma Concentrations of Methadone R- and S-enantiomers in Heroin-Dependent Patients.
  Yang Hsin-Chou, et al. PLoS genetics 2016 3 (3) e1005910
• The CDC Guideline on Opioid Prescribing- Rising to the Challenge
  Y. Olson, JAMA, March, 2016
• Correlation analysis between an IL-6 genetic polymorphism and non-small cell lung cancer prognosis.
  Zhao K, et al. Genetics and molecular research : GMR 2016 0 (1)
• Opioid metabolism and clinical aspects.
  Mercadante Sebastiano et al. European journal of pharmacology 2015 Dec 71-8
• The pharmacogenetics of opioid therapy in the management of postpartum pain: a systematic review.
  Baber Marta et al. Pharmacogenomics 2016 Jan (1) 75-93
• X Chromosome Inactivation in Opioid Addicted Women.
  Vousooghi Nasim, et al. Basic and clinical neuroscience 2015 7 (3) 179-84
• Human Genetic Variability Contributes to Post-operative Morphine Consumption.
  De Gregori Manuela, et al. The journal of pain : official journal of the American Pain Society 2016 2
• ABCC3 genetic variants are associated with postoperative morphine-induced respiratory depression and morphine pharmacokinetics in children.
  Chidambaran V, et al. The pharmacogenomics journal 2016 1
• The AC/AG Diplotype for the 118A>G and IVS2 + 691G>C Polymorphisms of OPRM1 Gene is Associated with Sleep Quality Among Opioid-Dependent Patients on Methadone Maintenance Therapy.
  Zahari Zalina, et al. Pain and therapy 2016 1
• Searching for evidence of genetic mediation of opioid withdrawal by opioid receptor gene polymorphisms.
  Jones Jermaine D, et al. The American journal on addictions / American Academy of Psychiatrists in Alcoholism and Addictions 2015 12
• Presence or Absence of QTc Prolongation in Buprenorphine-Naloxone Among Youth With Opioid Dependence.
  Poole Sabrina A, et al. Journal of addiction medicine 2015 12
• Clinical Implications of Opioid Pharmacogenomics in Patients With Cancer.
  Bell Gillian C, et al. Cancer control : journal of the Moffitt Cancer Center 2015 10 (4) 426-32
• Association of genetic and psychological factors with persistent pain after cosmetic thoracic surgery.
  Dimova Violeta, et al. Journal of pain research 2015 0 829-44
• Modeling respiratory depression induced by remifentanil and propofol during sedation and analgesia using a continuous noninvasive measurement of pCO2.
  Hannam Jacqueline A, et al. The Journal of pharmacology and experimental therapeutics 2015 12
• Increases in Drug and Opioid Overdose Deaths — United States, 2000–2014
  MMWR, December 18, 2015
• The Opposing Roles of IVS2+691 CC Genotype and AC/AG Diplotype of 118A>G and IVS2+691G>C of OPRM1 Polymorphisms in Cold Pain Tolerance Among Opioid-Dependent Malay Males on Methadone Therapy.
  Zahari Zalina, et al. Pain and therapy 2015 11
• Association of A118G polymorphism in the ?-opioid receptor gene with smoking behaviors: a meta-analysis.
  Wang Juan, et al. The Journal of toxicological sciences 2015 0 (6) 711-8
• Morphine-induced anti-nociception and reward in "humanized" mice expressing the mu opioid receptor A118G polymorphism.
  Henderson-Redmond Angela N, et al. Brain research bulletin 2015 10
• Mu Opioid Receptor Polymorphism, Early Social Adversity, and Social Traits.
  Carver Charles S, et al. Social neuroscience 2015 11
• Acute pain Factors predictive of post-operative pain and opioid requirement in multimodal analgesia following knee replacement.
  Thomazeau J, et al. European journal of pain (London, England) 2015 10
• Clues to opioid abuse from state prescription drug monitoring programs 
• Nonmedical Prescription Opioid Use and Use Disorders Among Adults Aged 18 Through 64 Years in the United States, 2003-2013
  B Han et al, JAMA< October 13, 2015
• Addressing the Opioid Epidemic
  LS Nelson et al, JAMA October 13, 2015
• [M1-OPIOID RECEPTOR AND CATECHOL-O-METILTRANSFERASE GENES POLYMORPHISM EFFECTS ON PERIOPERATIVE PSYCHOLOGICAL CONDITION OF THE PATIENTS AND THE EFFECTIVENESS OF POSTOPERATIVE ANALGESIA WITH OPIOIDS].
  Potapov A L, et al. Anesteziologiia i reanimatologiia 0 0 (3) 48-51

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Relevant Resources

• Cancer Genomics and Epidemiology Navigator (CGEN)
• Genetics and Genomics Competencies Center (G2C2)
• NIH Genetic Testing Registry
• NIH MedGen Database
• Online Mendelian Inheritance in Man (OMIM)
• PharmGKB