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Epigenetics & Chromatin

Featured article: Trypanosoma brucei

The compaction of DNA in chromatin in eukaryotes allowed the expansion of genome size and coincided with significant evolutionary diversification. However, chromatin generally represses DNA function, and mechanisms coevolved to regulate chromatin structure and its impact on DNA. This included the selection of specific nucleosome positions to modulate accessibility to the DNA molecule. Trypanosoma brucei, a member of the Excavates supergroup, falls in an ancient evolutionary branch of eukaryotes and provides valuable insight into the organization of chromatin in early genomes.

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Editors-in-Chief

Frank Grosveld, Erasmus University Medical Center
Steven Henikoff, Fred Hutchinson Cancer Research Center

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1. RESEARCH

   Differential DNA methylation at conserved non-genic elements and evidence for transgenerational inheritance following developmental exposure to mono(2-ethylhexyl) phthalate and 5-azacytidine in zebrafish

   Jorke H. Kamstra, Liana Bastos Sales, Peter Aleström and Juliette Legler

   Published on: 12 April 2017
2. RESEARCH

   Links between DNA methylation and nucleosome occupancy in the human genome

   Clayton K. Collings and John N. Anderson

   Published on: 11 April 2017
3. RESEARCH

   Fetal testis organ culture reproduces the dynamics of epigenetic reprogramming in rat gonocytes

   Arlette Rwigemera, Fabien Joao and Geraldine Delbes

   Published on: 11 April 2017
4. RESEARCH

   Internal modifications in the CENP-A nucleosome modulate centromeric dynamics

   Minh Bui, Mary Pitman, Arthur Nuccio, Serene Roque, Paul Gregory Donlin-Asp, Aleksandra Nita-Lazar, Garegin A. Papoian and Yamini Dalal

   Published on: 4 April 2017
5. RESEARCH

   Flightless-I governs cell fate by recruiting the SUMO isopeptidase SENP3 to distinct HOX genes

   Arnab Nayak, Anja Reck, Christian Morsczeck and Stefan Müller

   Published on: 23 March 2017

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