Genetics of Prostate Cancer (PDQ®)–Health Professional Version

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Changes to This Summary (06/29/2017)

The PDQ cancer information summaries are reviewed regularly and updated as new information becomes available. This section describes the latest changes made to this summary as of the date above.

Introduction

Added text to state that there is little evidence that family history alone is associated with inferior clinical outcomes. In a cohort of 7,690 men in Germany who were undergoing radical prostatectomy for localized prostate cancer, family history had no bearing on prostate cancer–specific survival (cited Brath et al. as reference 40).

Identifying Genes and Inherited Variants Associated With Prostate Cancer Risk

Added text to state that statistically well-powered genome-wide association studies have been launched to examine inherited cancer risk in Japanese and Chinese populations. Investigators discovered that these populations share many risk regions observed in African American men in other studies (cited Takata et al., Akamatsu et al., and Xu et al. as references 199, 200 and 201, respectively).

Genes With Potential Clinical Relevance in Prostate Cancer Risk

Revised text to state that five genes are implicated in mismatch repair.

Added NBN/NBS1 as a new subsection.

Added EPCAM as a new subsection.

This summary is written and maintained by the PDQ Cancer Genetics Editorial Board, which is editorially independent of NCI. The summary reflects an independent review of the literature and does not represent a policy statement of NCI or NIH. More information about summary policies and the role of the PDQ Editorial Boards in maintaining the PDQ summaries can be found on the About This PDQ Summary and PDQ® - NCI's Comprehensive Cancer Database pages.

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