More Detailed Information on Key Tier 1 Applications - Hereditary Breast and Ovarian Cancer (HBOC)
What is hereditary breast and ovarian cancer and how does it affect risk of cancer?
- BRCA mutations account for 3% of breast cancer and 10% of ovarian cancer cases in the U.S. each year[PDF 3.83 MB]
- Genetic tests are available to check for BRCA1 and BRCA2 mutations. Genetic counseling is recommended before and after the tests, to make sure that the risks and benefits are understood, that informed consent is achieved, and that the appropriate test is being ordered.
- If a harmful BRCA1 or BRCA2 mutation is found, several options are available to help reduce cancer risk.
- Many research studies are being conducted to find newer and better ways of detecting, treating, and preventing cancer in BRCA1 and BRCA2 mutation carriers.
- Multiple relatives with either breast or ovarian cancer;
- Breast cancer at a young age (under 50 years);
- Presence of breast and ovarian cancer among relatives;
- A relative with primary cancers of both breasts;
- One or more family members with two primary types of BRCA-related cancer;
- Presence of breast cancer in one or more male relatives;
- Ashkenazi Jewish ancestry;
- A relative with a known BRCA mutation.