Molecular neurodegeneration: novel systems and emerging concepts

Molecular Neurodegeneration: Novel Systems and Emerging Concepts

The 4th International Conference on Molecular Neurodegeneration (ICMN2016), held in Seoul, Republic of Korea, May 11-13 2016, gathered more than 300 participants from all over the world. In 14 scientific sessions including oral and poster presentations as well as panel discussions scientific progress under the theme ‘Novel Systems and Emerging Concepts’ was discussed. 

In this article collection, published by Molecular Neurodegeneration, the state-of-the-art scientific developments presented during the meeting are reviewed.

1. Content Type:Review

   Glial contributions to neurodegeneration in tauopathies

   Tauopathies are a broad set of neurodegenerative dementias characterized by aggregation of the tau protein into filamentous inclusions that can be found in neurons and glial cells. Activated microglia, astrocy...

   Authors:Cheryl E. G. Leyns and David M. Holtzman

   Citation:Molecular Neurodegeneration 2017 12:50

   Published on: 29 June 2017

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2. Content Type:Review

   Tau PET imaging: present and future directions

   Abnormal aggregation of tau in the brain is a major contributing factor in various neurodegenerative diseases. The role of tau phosphorylation in the pathophysiology of tauopathies remains unclear. Consequentl...

   Authors:Laure Saint-Aubert, Laetitia Lemoine, Konstantinos Chiotis, Antoine Leuzy, Elena Rodriguez-Vieitez and Agneta Nordberg

   Citation:Molecular Neurodegeneration 2017 12:19

   Published on: 20 February 2017

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3. Content Type:Review

   3D culture models of Alzheimer’s disease: a road map to a “cure-in-a-dish”

   Alzheimer’s disease (AD) transgenic mice have been used as a standard AD model for basic mechanistic studies and drug discovery. These mouse models showed symbolic AD pathologies including β-amyloid (Aβ) plaqu...

   Authors:Se Hoon Choi, Young Hye Kim, Luisa Quinti, Rudolph E. Tanzi and Doo Yeon Kim

   Citation:Molecular Neurodegeneration 2016 11:75

   Published on: 9 December 2016

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4. Content Type:Review

   LRRK2 at the interface of autophagosomes, endosomes and lysosomes

   Over the past 20 years, substantial progress has been made in identifying the underlying genetics of Parkinson’s disease (PD). Of the known genes, LRRK2 is a major genetic contributor to PD. However, the exact...

   Authors:Dorien A. Roosen and Mark R. Cookson

   Citation:Molecular Neurodegeneration 2016 11:73

   Published on: 7 December 2016

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