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viernes, 21 de junio de 2019

Pharmacy / Pharmacology | Medical News | Medical Articles | Pharmacy / Pharmacology |

	June 21, 2019
	Pharmacy / Pharmacology
	The latest pharmacy / pharmacology news from News Medical

Developing Sustained Release Pharmaceuticals

A Sustained-Release Drug Delivery System is specially designed to provide a drug in the human body at a predetermined and constant rate (zero order dissolution). In this way, the level of a drug can be maintained at a continuous level, usually over an extended period of time with the least possible side-effects. Release of the ‘active’ at a constant rate regardless of its concentration in the dosage form is the ideal outcome. The reason for timed or sustained release drugs is related to the half-life of the drug in the body.

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			Short Hairpin RNA (shRNA) Interference: Therapeutic Applications RNA interference is a biological process that has evolved with the evolution of mammals and plays an important role in transient and long-term blocking of protein expression. Short Hairpin RNA (shRNA) interference has many therapeutic applications, and research is still ongoing into new areas of focus.

			Alcohol, Cannabis and Other Drugs: A Pharmacological Evaluation The abuse of alcohol and other drugs like narcotics, sedatives and stimulants continues to be a major global public health concern. This international crisis is further heightened by the tendency of many users to poly-drug abuse, which is a condition defined as the simultaneous or successive abuse of more than one drug or type of drug by an individual who has dependence on at least one of those drugs.

	The Role of the CD38 Receptor in the Progression of HIV CD38, or cyclic ADP ribose hydrolase, is a glycoprotein found on the surface of many immune cells. Binding of CD38 to its target ligand results in T cell co-stimulation, B cell maturation, and induction of cytokine production by several cell types.

	Benfotiamine Health Benefits and Side Effects Benfotiamine is a lipid-soluble derivative of thiamine. The increased lipid solubility of benfotiamine allows it to penetrate nerve cells more easily. After oral intake, benfotiamine shows increased bioavailability compared with an equivalent dose of water-soluble thiamine. Benfotiamine may, therefore, be a better option to treat thiamine deficiency than its water-soluble counterpart.

	Understanding Lead Optimization The drug discovery process begins with recognizing a disease or clinical condition in which there is a lack of adequate medical treatment. Once a potential drug has been identified, pre-clinical research can begin. This process includes several stages; the first of which involves identifying and validating the prospective drug’s target through assay development, high throughput screening, hit identification and finally, lead optimization.

	Scientists uncover unique set of genes that play a role in muscle cellular gene regulation York University scientists have uncovered a unique set of genes that play a role in muscle cellular gene expression and differentiation which could lead to new therapeutic targets to prevent the spread of muscle cancer.