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Genomics|Features|Smoking

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Smoking Cessation: Genomics and Public Health - May 28, 2015

CDC and Related Info

• E-cigarette use triples among middle and high school students in just one year
• 58 million nonsmokers in US are still exposed to secondhand smoke
• Secondhand smoke exposure is harmful and remains high for certain groups
• CDC's Tips from former smokers campaign provided outstanding return on investment
• More than 16 million children live in states where they can buy e-cigarettes legally
• CDC blog post (2012):Smokescreen: What's genomics got to do with smoking?
• Genes reported in relation to smoking, including genomewide association studies via theHuGE Navigator

World No Tobacco Day - May 31, 2015
MMWR, May 29, 2015

Lack of associations of CHRNA5-A3-B4 genetic variants with smoking cessation treatment outcomes in Caucasian smokers despite associations with baseline smoking.
Tyndale RF et al. PLoS ONE 2015 (5) e0128109

Genetic ancestry as an effect modifier of naltrexone in smoking cessation among African Americans: an analysis of a randomized controlled trial.
Bress A et al. Pharmacogenet. Genomics 2015 Jun (6) 305-12

The association of rs1051730 genotype on adherence to and consumption of prescribed nicotine replacement therapy dose during a smoking cessation attempt.
Ware JJ et al. Drug Alcohol Depend 2015 Jun 1. 236-40

Persistence of smoking-induced dysregulation of miRNA expression in the small airway epithelium despite smoking cessation.
Wang G et al. PLoS ONE 2015 (4) e0120824

Lack of association between DRD2 Taq1A gene polymorphism and smoking cessation therapy: a meta-analysis.
Choi HD et al. Int J Clin Pharmacol Ther 2015 Apr 17.

CHRNA5 risk variant predicts delayed smoking cessation and earlier lung cancer diagnosis-a meta-analysis.
Chen Li-S et al. J. Natl. Cancer Inst. 2015 May (5)

Are genetic variants for tobacco smoking associated with cannabis involvement?
Agrawal A et al. Drug Alcohol Depend 2015 May 1. 183-7

Pharmacogenetics of nicotine and associated smoking behaviors.
Tanner Julie-A et al. Curr Top Behav Neurosci 2015 37-86

Smoking: More Public Health and Genomic Insights - April 23, 2015

E-cigarette use triples among middle and high school students in just one year
MMWR April 2015

CDC Newsroom: 58 million nonsmokers in US are still exposed to secondhand smoke
Two of every five children -- including seven in 10 black children -- are exposed, February 2015

CDC Infographic: Secondhand smoke exposure is harmful and remains high for certain groups.

Smoking's toll on health is even worse than previously thought, a study finds, by Denise Grady, New York Times, Feb 11

Smoking and mortality--beyond established causes.
Carter Brian D et al. N. Engl. J. Med. 2015 Feb 12. (7) 631-40

Genome-wide association study of nicotine dependence in american populations: identification of novel risk Loci in both African-Americans and European-Americans.
Gelernter Joel et al. Biol. Psychiatry 2015 Mar 1. (5) 493-503

Stratification by smoking status reveals an association of CHRNA5-A3-B4 genotype with body mass index in never smokers.
Taylor Amy E et al. PLoS Genet. 2014 Dec (12) e1004799

Interaction between passive smoking and two HLA genes with regard to multiple sclerosis risk.
Hedström Anna Karin et al. Int J Epidemiol 2014 Dec (6) 1791-8

Interaction of intercellular adhesion molecule 1 (ICAM1) polymorphisms and environmental tobacco smoke on childhood asthma.
Li Yu-Fen et al. Int J Environ Res Public Health 2014 Jun (6) 6504-16

Pharmacogenetics of nicotine and associated smoking behaviors.
Tanner Julie-Anne et al. Curr Top Behav Neurosci 2015 37-86

Polygenic score × intervention moderation: An application of discrete-time survival analysis to modeling the timing of first tobacco use among urban youth.
Musci Rashelle J et al. Dev. Psychopathol. 2015 Feb (1) 111-22

Smoking Cessation: Genetic Influences on Nicotine Metabolism - January 20, 2015

Patch or pills? How quickly smokers metabolize nicotine may point to most effective way to quit, Science Daily, Jan 11

Use of the nicotine metabolite ratio as a genetically informed biomarker of response to nicotine patch or varenicline for smoking cessation: a randomised, double-blind placebo-controlled trial
Caryn Lerman, et al. Lancet Respiratory Medicine, January 2015

Smoking Cessation: Tips, E-Cigarettes and Genomics - December 18, 2014

CDC information: CDC's Tips from former smokers campaign provided outstanding return on investment. National mass media anti-smoking campaign exceptionally cost-effective

CDC  information: More than 16 million children live in states where they can buy e-cigarettes legally. More than 300 million Americans live in states without protection against indoor e-cigarette aerosol exposure

Commentary: Even more illness caused by smoking than previously estimated 
Steven A. Schroeder, JAMA Internal Medicine, December 2014

Recent Genomic Insights

Smokers' beliefs about the tobacco control potential of "a gene for smoking": a focus group study.
Waters EA, et al. BMC Public Health. 2014 Nov 25;14:1218

Investigating the possible causal association of smoking with depression and anxiety using Mendelian randomisation meta-analysis: the CARTA consortium.
Taylor AE, BMJ Open. 2014 Oct 7;4(10):e006141.

Smoking behaviour: investigation of the coaction of environmental and genetic risk factors.
Treutlein J, et al. Psychiatr Genet. 2014 Dec;24(6):279-80

Novel genetic variants modify the effect of smoking on carotid plaque burden in Hispanics.
Della-Morte D, et al. J Neurol Sci. 2014 Sep 15;344(1-2):27-31

Check out genetic association studies reporting on smoking using the HuGE Navigator

Smoking Cessation: Public Health and Genetic Insights - October 22, 2014

Increases in smoking cessation interventions after a feedback and improvement initiative using electronic health records — 19 community health centers, New York City, October 2010–March 2012 
Sheryl L. Silfen, et al. MMWR 2014;63:921-4

The genetic architecture of smoking and smoking cessation 
dbGaP Study Accession: phs000404.v1.p1 This study includes samples from two projects:

Genomics and personalized medicine: CHRNA5-CHRNA3-CHRNB4 and smoking cessation treatment. 
Chen LS, Bierut LJ. J Food Drug Anal. 2013 Dec;21(4):S87-S90.

Interplay of genetic risk (CHRNA5) and environmental risk (partner smoking) on cigarette smoking reduction. 
Chen LS, et al. Drug Alcohol Depend. 2014 Oct 1;143:36-43.

Impact of genetic notification on smoking cessation: Systematic review and pooled-analysis. 
Sylviane de Viron et al. PLOS One, 2012

CHRNA5 variant predicts smoking cessation in patients with acute myocardial infarction. 
Chen LS, et al. Nicotine Tob Res. 2014 Sep;16(9):1224-31

Environmental and genomic factors influencing smoking cessation: A systematic review of reviews and a proposed working model
de Viron S et al. Public Health Genomics (2013)

CDC blog post (2012): Smokescreen: What's genomics got to do with smoking?

Find out about genetic conditions and tests associated with smoking from the NIH Genetic Testing Registry

Did you know? There are thousands of genes reported in relation to smoking addiction and adverse health outcomes, including > 100 genomewide association studies. Check out the HuGE Navigator