lunes, 19 de diciembre de 2016
Brain Cancer’s Cholesterol Addiction May Offer New Treatment Strategy - National Cancer Institute
Targeting Cholesterol in Brain Cancer - National Cancer Institute
To survive and grow, brain cancer cells are heavily dependent on a constant supply of cholesterol provided by other brain cells, a new study suggests. Moreover, the researchers found that brain cancer cells take in more cholesterol than normal brain cells and subvert normal mechanisms of cholesterol regulation, allowing them to stockpile cholesterol. But this dependency creates a potential vulnerability, the researchers showed. In mice with human brain tumors, treatment with a drug that depletes cholesterol killed tumor cells, slowed tumor growth, and improved survival.