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Genomics|Features|Depression

Depression

Depression: Public Health and Genomic Insights - July 15, 2015

CDC and Related Info

• CDC mental health basics
• Suicide, family health history, and genomics
• Genes reported in relation to depression, including genomewide association studies via theHuGE Navigator

Sparse whole-genome sequencing identifies two loci for major depressive disorder
CONVERGE consortium, Nature, July 15, 2015

Genetic polymorphisms might predict suicide attempts in mental disorder patients: a systematic review and meta-analysis.
de Medeiros AV et al. CNS Neurol Disord Drug Targets 2015 Jul 12.

The role of allelic variation in estrogen receptor genes and major depression in the Nurses Health Study.
Keyes K et al. Soc Psychiatry Psychiatr Epidemiol 2015 Jul 14.

Genetic sensitivity to emotional cues, racial discrimination and depressive symptoms among African-American adolescent females.
Sales JM et al. Front Psychol 2015 854

The role of GRIK4 gene in treatment-resistant depression.
Milanesi E et al. Genet Res (Camb) 2015 e14

Polygenic dissection of major depression clinical heterogeneity.
Milaneschi Y et al. Mol. Psychiatry 2015 Jun 30.

Genetic association of the oxytocin receptor genes with panic, major depressive disorder, and social anxiety disorder.
Onodera M et al. Psychiatr. Genet. 2015 Jun 23.

The interaction between stress and genetic factors in the etiopathogenesis of depression.
McGuffin P et al. World Psychiatry 2015 Jun (2) 161-3

Genetic moderation of the association between adolescent romantic involvement and depression: Contributions of serotonin transporter gene polymorphism, chronic stress, and family discord.
Starr LR et al. Dev. Psychopathol. 2015 Jun 3. 1-11

MTHFR: Genetic variants, expression analysis and COMT interaction in major depressive disorder.
Gabriela NM et al. J Affect Disord 2015 Sep 1. 179-86

Depression: Medical Research and Genomics - November 19, 2014

Mental health: The great depression. Depression causes more disability than any other disorder. A special issue explores how science can help. 
Nature, 12 November 2014 

The burden of depression: Mental health is gaining acceptance as a medical problem, but progress in finding treatments is being hampered by the stigma surrounding people's everyday experiences. 
Nature editorial 12 November 2014

Medical research: If depression were cancer. Research into depression has struggled, while studies of cancer have thrived — but the balance could be shifting. 
Heidi Ledford, Nature 12 November 2014

Mental health: Depression needs large human-genetics studies. 
Steven Hyman. Nature, 12 November 2014

Genomic insights into the overlap between psychiatric disorders: implications for research and clinical practice. 
Doherty JL, et al. Genome Med. 2014 Apr 28;6(4):29.

Biomarkers in major depressive disorder: the role of mass spectrometry.
Woods AG, et al. Adv Exp Med Biol. 2014;806:545-60.

Depression: Family Health History, Genetics and Recent Genomic Insights into Diagnosis - September 25, 2014

CDC mental health basics

CDC blog post: Suicide, family health history, and genomics

Mayo Clinic Information on depression and its causes and risk factor: Depression is more common in people whose biological (blood) relatives also have this condition. Researchers are trying to find genes that may be involved in causing depression

Is depression genetic? Stephanie Faris, HealthLine, August 12

Did you know? 491 genes have been reported in relation to risk and outcomes of depression, including 64 genomewide association studies. To find out more, visit the HuGE Navigator

Check out genetic conditions and tests associated with depression from the NIH Genetic Testing Registry

Blood transcriptomic biomarkers in adult primary care patients with major depressive disorder undergoing cognitive behavioral therapy. 
E E Redei et al. Translational Psychiatry, August 2014