SICKLE CELL DISEASE ▲ Public Health Genomics Knowledge Base (v1.2)

Public Health Genomics Knowledge Base (v1.2)

SICKLE CELL DISEASE

Last Updated: Oct 13, 2016

• 3 Gene Editing Approaches for Sickle Cell Disease 
  R Lewis, PLOS Blogs, October 13, 2016
• CRISPR deployed to combat sickle-cell anaemia
  H Ledford, Nature News, October 12, 2016
• 3 Gene Editing Approaches for Sickle Cell Disease 
  R Lewis, PLOS Blogs, October 13, 2016
• Interventions for patients and caregivers to improve knowledge of sickle cell disease and recognition of its related complications.
  Asnani Monika R et al. The Cochrane database of systematic reviews 2016 Oct 10CD011175
• With CRISPR, scientists correct genetic mutation that causes sickle cell disease
  LA Times, October 12, 2016
• Phenotyping and genotyping of CYP2C19 using comparative metabolism of proguanil in sickle-cell disease patients and healthy controls in Nigeria.
  Adejumo Olufunmilayo E, et al. Pharmacology research & perspectives 2016 10 (5) e00252
• Association between a combination of single nucleotide polymorphisms and large vessel cerebral vasculopathy in African children with sickle cell disease.
  Martella Maddalena, et al. Blood cells, molecules & diseases 2016 10 1-3
• An Expert Review of Pharmacogenomics of Sickle Cell Disease Therapeutics: Not Yet Ready for Global Precision Medicine.
  Mnika Khuthala et al. Omics : a journal of integrative biology 2016 Sep
• Gene therapy for sickle cell disease passes key preclinical test
  Harvard Gazettte, September 2016
• Genome-Wide Analysis Identifies IL-18 and FUCA2 as Novel Genes Associated with Diastolic Function in African Americans with Sickle Cell Disease.
  Duarte Julio D, et al. PloS one 2016 0 (9) e0163013
• Prevalence of Sickle Cell Trait and Reliability of Self-Reported Status among Expectant Parents in Nigeria: Implications for Targeted Newborn Screening.
  Burnham-Marusich Amanda R et al. Public health genomics 2016 Sep 19(5)
• Public Health Research, Epidemiology, and Surveillance for Hemoglobinopathies (PHRESH) 
• Sickle Cell Awareness 
• Sickle Cell Data Collection (SCDC) Program 
• Gene therapy for sickle cell moves closer as scientists clear unexpected obstacle
  StatNews, September 7, 2016

• CDC Information (12)
• CDC-Authored Pub (16)

• Human (24)
• Pathogen (1)

• Human (272)
• Pathogen (0)

• Human (55)
• Pathogen (0)

• Guidelines (2)
• Tier Table (0)
• Synthesis (6)

• Huamn (8)
• Pathogen (0)

Relevant Resources

• Cancer Genomics and Epidemiology Navigator (CGEN)
• Genetics and Genomics Competencies Center (G2C2)
• NIH Genetic Testing Registry
• NIH MedGen Database
• Online Mendelian Inheritance in Man (OMIM)
• PharmGKB