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Genomics|Features|Precision Medicine

Precision Medicine

Precision Medicine In Action - May 20, 2015

CDC Info

• When a country cannot be a cohort: Challenges of implementing a large precision medicine cohort study in the United States
• Precision public health and precision medicine: two peas in a pod
• The success of precision medicine requires a public health perspective
• A population perspective on personalized medicine
• Population sciences, translational research, and the opportunities and challenges for genomics to reduce the burden of cancer in the 21st century
• Medicine. Big data meets public health
• The public health role in translating advances in genomics
• CDC Advanced Molecular Detection infectious disease initiative

No more hidden solutions in bioinformatics
Precision medicine cannot advance without full disclosure of how commercial genome sequencing and interpretation software works, says Mauno Vihinen, Nature News, May 20, 2015

Precision medicine in action: Genomics can help to target treatments for patients with cancer, rare inherited conditions, and infectious diseases,  Genomics Education Program, May 12, 2015

New developments in personalized medicine could save billions of dollars in improved health 
Personalised medical interventions to prevent heart disease could generate $114 billion worth of heath gains in United States- Eureka Alert, May 6

Aligning incentives to fulfil the promise of personalised medicine
Dzau VJ et al. Lancet May 2015

The Precision Medicine Initiative - a new national effort
Ashley EA, JAMA 2015 Apr 30

NIH's Collins on changing the future of medicine, Medscape Interview with Dr Eric Topol, March 2015

Obama catapults patient-empowered precision medicine
Fox JL. Nature Biotechnology, April 2015

Is precision medicine the route to a healthy world?
Coote J et al. Lancet, April 2015

Personalized medicine: Time for one-person trials
Precision medicine requires a different type of clinical trial that focuses on individual, not average, responses to therapy, says Nicholas J. Schork. Nature News, April 29, 2015

Precision Medicine: Building a Cohort of 1 Million People - April 28, 2015

NIH Workshop: Unique scientific opportunities for the Precision Medicine Initiative National Research Cohort
April 28-29, 2015 ~ Bethesda, MD

NIH request for information seeks feedback to help guide the longitudinal cohort of 1 million or more Americans who have volunteered to participate in research 
As part of the President's proposed Precision Medicine Initiative

NIH precision medicine events and workshops

Precision Medicine Initiative: Building a large U.S. research cohort  [PDF 508.60 KB]
NIH Workshop February 2015 Summary

NIH forms team of experts to chart course for the President's Precision Medicine Initiative research network, NIH, Mar 30

New CDC blog post: When a country cannot be a cohort: Challenges of implementing a large precision medicine cohort study in the United States

Workshop Presentation Slides: Building a Large U.S. Research Cohort
Precision Medicine Initiative

NIH Workshop on Building a Precision Medicine Research Cohort

Building a Consortium of Cohorts — Cohort Identification and Participant Recruitment  [PDF 193 KB]

Participant Engagement, Data Privacy, and Novel Ways of Returning Information to Participants  [PDF 152 KB]

Data Collection and Mobile Technologies  [PDF 737 KB]

Opportunities and Challenges Related to the Use of Electronic Health Records Data for Research  [PDF 184 KB]

FDA outlines plan for expected $10M under President's Precision Medicine Plan, Genome Web, Feb 18 [by free subscription only]

The NCI Cancer Epidemiology Descriptive Cohort Database 
Provides descriptive information on cohorts studying cancer as a primary outcome.

More on Precision Medicine - March 18, 2015

Precision medicine: The future or simply politics? 
Rubin R, JAMA, March 17, 2015

Precision Medicine Initiative.
Porche DJ et al. Am J Mens Health 2015 Mar 10.

Obama 2016 budget calls for precision medicine.
Nat. Biotechnol. 2015 Mar 6. (3) 216

Putting precision medicine on the national agenda.
Tempero M et al. J Natl Compr Canc Netw 2015 Mar (3) 251

Making personalized medicine more affordable.
Aronson N et al. Ann. N. Y. Acad. Sci. 2015 Feb 27.

Editorial: rethinking the definition of diabetes for precision medicine.
Ahima RS et al. Mol. Endocrinol. 2015 Mar (3) 335-7

Application of molecular profiling in clinical trials for advanced metastatic cancers.
Kummar S et al. J. Natl. Cancer Inst. 2015 Apr (4)

Precision Public Health and Precision Medicine: An Evolving Relationship - March 2, 2015

New CDC blog post: Precision public health and precision medicine: two peas in a pod

CDC Advanced Molecular Detection infectious disease initiative 
Will improve the ability of public health to detect outbreaks sooner and respond more effectively, saving lives and reducing cost

CDC's vision for public health surveillance in the 21st century  [PDF 872.86 KB]
MMWR 2012; suppl 61

We screen newborns, don't we?: realizing the promise of public health genomics.
Evans James P et al. Genet. Med. 2013 May (5) 332-4

CDC National Diabetes Prevention Program

Precision medicine: Not just "genes, drugs, and disease", by William Riley, OBSSR, February 2, 2015

Medicine. Big data meets public health.
Khoury Muin J et al. Science 2014 Nov 28. (6213) 1054-5

CDC National Biomonitoring Program 
Assesses nutritional status and the exposure of the U.S. population to environmental chemicals and toxic substances

Precision Medicine: Insights on Benefits, Harms & Costs - February 9, 2015

Genomics, the data revolution, and health economics - the 2015 Astellas Innovation Debate, BMJ Blog Post, James Buchanan, February 2, 2015

Precision medicine is already working to cure Americans: These are their stories, by Lindsay Holst, White House Blog Post, Jan 30

The high price of precision healthcare, Joseph Guinto, Genome Magazine, January 2015

Big precision medicine plan raises patient privacy concerns, Scientific American, Feb 3

The problem with precision medicine, by Cynthia Graber , New Yorker, Feb 5

Moving precision medicine beyond the hype, Genome Web, Feb 6 [by free subscription only]

Precision medicine: Friend or foe? By David May, ACC in Touch Blog, Feb 6

Medicine just for you, by the Editorial Board, New York Times, Feb 7

More on Precision Medicine: Building a Cohort Consortium - February 2, 2015

Precision medicine initiative and cancer research,  by Harold Varmus, NCI, Jan 30

NIH Workshop: Building a precision medicine cohort, February 11-12, 2015

The NCI Cohort Consortium

New models for large prospective studies: is there a better way?
Manolio TA, et al. Am J Epidemiol. 2012

Precision medicine may never be very precise - but it may be good for public health, by Jeff Leek, SImPLYSTATS, Jan 30

Precision Medicine: Public Health Perspectives - January 30, 2015

Fact sheet: President Obama’s Precision Medicine Initiative, the White House, Jan 30

President Obama versus the naysayers: A big week for "precision" medicine, by Mark Wanner, Jackson Laboratory, Jan 30

A new initiative on precision medicine
Francis S. Collins and Harold Varmus, New England Journal of Medicine January 30, 2015

The Precision Medicine Initiative: Data-driven treatments as unique as your own body, Linsay Holtz, the White House, Jan 30

NIH information: the Precision Medicine Initiative

New CDC blog post: The success of precision medicine requires a public health perspective

CDC paper: A population approach to precision medicine. 
Khoury MJ, et al. Am J Prev Med.

CDC paper: The public health role in translating advances in genomics. 
Khoury MJ, Bowen S. Clinical Omics, August 13, 2014

Precision medicine: Improving health and treating disease, by Jo Handelsman, Associate Director for Science at the White House Office of Science and Technology, HHS Blog, Jan 22

US President launches ‘precision medicine’ initiative, The Pharmaceutical Journal, Jan 23

Obama to request research funding for treatments tailored to patients’ DNA, New York Times, Jan 24

The Genomics and Personalized Medicine Act of 2007

Obama precision medicine plan would create huge U.S. genetic biobank, by Jocelyn Kaiser, Science Magazine, Jan 29

Precision Medicine: Cancer and Genomics - January 21, 2015

What is “precision medicine? Information from the National Cancer Institute

Impact of cancer genomics on precision medicine for the treatment of cancer, from the Cancer Genome Atlas, NCI

US precision-medicine proposal sparks questions, by Sara Reardon, Nature News, Jan 22

Obama's 'precision medicine' means gene mapping, NBC News, Jan 21

What is President Obama's 'precision medicine' plan, and how might it help you? By Lenny Bernstein, Jan 21

Obama proposes new Precision Medicine Initiative for genetic treatments,  by Russell Brandom, The Verge, Jan 20

U.S. developing large-scale genomics project, Biocentury, Jan 16

Recent reviews

Companion diagnostics: the key to personalized medicine.
Jørgensen JT. Expert Rev Mol Diagn. 2015 Feb;15(2):153-6

Promoting precision cancer medicine through a community-driven knowledgebase.
Geifman N, et al. J Pers Med. 2014 Dec 15;4(4):475-88.

Toward a prostate cancer precision medicine.
Rubin MA. Urol Oncol. 2014 Nov 20.

Prioritizing targets for precision cancer medicine.
Andre F, et al. Ann Oncol. 2014 Dec;25(12):2295-303

Toward precision medicine with next-generation EGFR inhibitors in non-small-cell lung cancer.
Yap TA, Popat S. Pharmgenomics Pers Med. 2014 Sep 19;7:285-95.

Genomically driven precision medicine to improve outcomes in anaplastic thyroid cancer.
Pinto N, et al.  J Oncol. 2014;936285

Translating genomics for precision cancer medicine.
Roychowdhury S, Chinnaiyan AM. Annu Rev Genomics Hum Genet. 2014;15:395-415

Cancer Precision Medicine: Where Are We? - September 18, 2014

NIH announces the launch of 3 integrated precision medicine trials; ALCHEMIST is for patients with certain types of early-stage lung cancer, August 2014 

National Cancer Institute's Precision Medicine Initiatives for the New National Clinical Trials Network.Jeffrey Abrams et al. ASCO Annual Meeting 2014 

Personalized medicine: Special treatment. 
Michael Eisenstein. Nature, September 11, 2014

Why the controversy? Start sequencing tumor genes at diagnosis. Tumor sequencing at the time of diagnosis can give significant insight for successful cancer treatment, by Shelly Gunn, Genetic Engineering & Biotechnology News, Sep 10  

National Cancer Institute information: Precision medicine and targeted therapy

Genomics and precision oncology: What's a targeted therapy for cancer? An updated list of approved drugs from the National Cancer Institute (2014)

Therapy: This time it's personal
Gravitz L Nature 509, S52-S54 2014 May 29

Multi-marker solid tumor panels using next-generation sequencing to direct molecularly targeted therapies 
Michael Marrone, et al. PLoS Currents Evidence on Genomic Tests 2014 May 27

Impact of cancer genomics on precision medicine for the treatment of cancer, from the National Cancer Institute

Cancer genomics and precision medicine in the 21st century  [PDF 2.20 MB], power point presentation from the National Human Genome Research Institute

Personalized Medicine: Opportunities & Challenges - July 2, 2014

The Case for Personalized Medicine - 4th Edition,Personalized Medicine Coalition 2014

Food and Drug Administration Report: Paving the way for personalized medicine  [PDF 854.45 KB] (2013)

CDC paper: A population perspective on personalized medicine

CDC paper: Population sciences, translational research, and the opportunities and challenges for genomics to reduce the burden of cancer in the 21st century.

Policy and health profession must adapt to personalised medicine, PHG Foundation, June 26, 2014

Reading between the lines; understanding drug response in the post genomic era. 
Alifrangis CC1, McDermott U. Mol Oncol. 2014 Jun 10. pii: S1574-7891

How does genome sequencing impact surgery? 
Marlies S. Reimers et al.  Nature Reviews Clinical Oncology 2014 Jun 24

Lung-MAP launches: first precision medicine trial from National Clinical Trials Network, by the ASCO Post, Jun 25