Breast & Ovarian Cancer
Breast Cancer Gene Panels: Opportunities and Challenges - May 27, 2015
CDC Info
- CDC blog post:Using genomics in precision prevention of breast cancer
- CDC Medscape Expert Commentary:Genetics and BRCA in Primary Care
- Does breast or ovarian cancer run in your family?
- Public health genomics implementation tool kit for health departments - check out BRCA section
- How can we use genetic testing for stratified screening for common diseases such as breast cancer?
- CDC Know:BRCA Tool
- Knowing BRCA changed my life
Gene-panel sequencing and the prediction of breast-cancer risk
Easton DF et al. NEJM,May 27, 2015
Easton DF et al. NEJM,May 27, 2015
Inherited mutations in 17 breast cancer susceptibility genes among a large triple-negative breast cancer cohort unselected for family history of breast cancer.
Couch FJ et al. J. Clin. Oncol. 2015 Feb 1. (4) 304-11
Couch FJ et al. J. Clin. Oncol. 2015 Feb 1. (4) 304-11
Testing for hereditary breast cancer: panel or targeted testing? Experience from a clinical cancer genetics practice.
Doherty Jr et al. J Genet Couns 2014 Dec 5.
Doherty Jr et al. J Genet Couns 2014 Dec 5.
Beyond BRCA1 and BRCA2.
King-Spohn K et al. Curr Probl Cancer 2014 Nov-Dec (6) 235-48
King-Spohn K et al. Curr Probl Cancer 2014 Nov-Dec (6) 235-48
Next-generation sequencing for hereditary breast and gynecologic cancer risk assessment.
Kurian AW et al. Curr. Opin. Obstet. Gynecol. 2015 Feb (1) 23-33
Kurian AW et al. Curr. Opin. Obstet. Gynecol. 2015 Feb (1) 23-33
Hereditary breast cancer syndromes and genetic testing.
Rich TA et al. J Surg Oncol 2015 Jan (1) 66-80
Rich TA et al. J Surg Oncol 2015 Jan (1) 66-80
Hereditary breast cancer: an update on risk assessment and genetic testing in 2015.
Stuckey AR et al. Am. J. Obstet. Gynecol. 2015 Mar 3.
Stuckey AR et al. Am. J. Obstet. Gynecol. 2015 Mar 3.
Breast Cancer in Young Women: Recent Insights - May 27, 2015
Family history and outcome of young patients with breast cancer in the UK (POSH study).
Eccles BK et al. Br J Surg 2015 May 20.
Eccles BK et al. Br J Surg 2015 May 20.
Gene expression in "young adult type" breast cancer: a retrospective analysis.
Johnson RH et al. Oncotarget 2015 May 9.
Johnson RH et al. Oncotarget 2015 May 9.
Breast cancer in very young women: Clinicopathological study of 149 patients ≤25 years old.
de Deus Moura R et al. Breast 2015 May 19.
de Deus Moura R et al. Breast 2015 May 19.
The expression of CXCL13 and its relation to unfavorable clinical characteristics in young breast cancer.
Chen L et al. J Transl Med 2015 May 20. (1) 168
Chen L et al. J Transl Med 2015 May 20. (1) 168
Experiences of women who underwent predictive BRCA 1/2 mutation testing before the age of 30.
Brunstrom K et al. J Genet Couns 2015 May 19.
Brunstrom K et al. J Genet Couns 2015 May 19.
Evaluation of BRCA1/2 mutational status among German and Austrian women with triple-negative breast cancer.
Muendlein A et al. J. Cancer Res. Clin. Oncol. 2015 May 15.
Muendlein A et al. J. Cancer Res. Clin. Oncol. 2015 May 15.
High prevalence of the BIM deletion polymorphism in young female breast cancer in an East Asian country.
Lin Ching-Hung et al. PLoS ONE 2015 (4) e0124908
Lin Ching-Hung et al. PLoS ONE 2015 (4) e0124908
Increasing disparities in breast cancer mortality from 1979 to 2010 for US black women aged 20 to 49 years.
McCarthy AM et al. Am J Public Health 2015 Apr 23. e1-e3
McCarthy AM et al. Am J Public Health 2015 Apr 23. e1-e3
Preferences for return of incidental findings from genome sequencing among women diagnosed with breast cancer at a young age.
Kaphingst KA et al. Clin. Genet. 2015 Apr 13
Kaphingst KA et al. Clin. Genet. 2015 Apr 13
.BRCA1 and BRCA2 mutations in ethnic Lebanese Arab women with high hereditary risk breast cancer.
El Saghir NS et al. Oncologist 2015 Apr (4) 357-64
El Saghir NS et al. Oncologist 2015 Apr (4) 357-64
Factors influencing breast cancer screening and risk assessment among young African American women: An integrative review of the literature.
Jones TP et al. J Am Assoc Nurse Pract 2015 Mar 3.
Jones TP et al. J Am Assoc Nurse Pract 2015 Mar 3.
Breast cancer in young women: Share your story - May 4, 2015
CDC information: Share your story. Empower and educate young women
About 11% of new breast cancer cases in the United States affect women under the age of 45, but many young women may not realize they are at risk for this disease.
About 11% of new breast cancer cases in the United States affect women under the age of 45, but many young women may not realize they are at risk for this disease.
CDC Know:BRCA Tool
Some women carry certain genetic changes in their BRCA genes that increase their risks for getting breast, ovarian, and other kinds of cancers at a young age
Some women carry certain genetic changes in their BRCA genes that increase their risks for getting breast, ovarian, and other kinds of cancers at a young age
Knowing BRCA changed my life, by Debbie Wasserman Schultz, CDC Blog Post 2014
Why I am having a double mastectomy
A 34-year-old mother of two young daughters explains how she reached her difficult decision to have the "Angelina Jolie" procedure, The Guardian, May 2, 2015
A 34-year-old mother of two young daughters explains how she reached her difficult decision to have the "Angelina Jolie" procedure, The Guardian, May 2, 2015
CDC information: Does breast or ovarian cancer run in your family?
Webinar: Hereditary breast and ovarian cancer in public health, Genetic Alliance, 2014
Genetic Alliance, 2014CDC Tier 1 Genomic Applications Implementation Toolkit for Public Health Departments
Detailed Information on Hereditary Breast and Ovarian Cancer (HBOC)
Detailed Information on Hereditary Breast and Ovarian Cancer (HBOC)
CDC Podcast: Genetics and BRCA in primary care, Medscape, 2014
Medscape, 2014Association of type and location of BRCA1 and BRCA2 mutations with risk of breast and ovarian cancer.
Rebbeck TR et al. JAMA 2015 Apr 7. (13) 1347-61
Rebbeck TR et al. JAMA 2015 Apr 7. (13) 1347-61
Effect of oophorectomy on survival after breast cancer in BRCA1 and BRCA2 mutation carriers
Metcalfe K et al. JAMA Oncology, April 23, 2015
Metcalfe K et al. JAMA Oncology, April 23, 2015
Breast Cancer: Genomics in Prediction and Stratified Screening - April 23, 2014
New CDC blog post: Using genomics in precision prevention of breast cancer
Hereditary breast and ovarian cancers: moving toward more precise prevention, NIH Director Blog Post, Apr 14
NIH Director Blog Post, Apr 14Prediction of breast cancer risk based on profiling with common genetic variants.
Mavaddat N et al. J. Natl. Cancer Inst. 2015 May (5)
Mavaddat N et al. J. Natl. Cancer Inst. 2015 May (5)
Twenty-five years of breast cancer risk models and their applications.
Gail MH et al. J. Natl. Cancer Inst. 2015 May (5)
Gail MH et al. J. Natl. Cancer Inst. 2015 May (5)
Breast cancer prevention in the era of precision medicine.
Narod SA et al. J. Natl. Cancer Inst. 2015 May (5)
Narod SA et al. J. Natl. Cancer Inst. 2015 May (5)
The contributions of breast density and common genetic variation to breast cancer risk.
Vachon CM et al. J. Natl. Cancer Inst. 2015 May (5)
Vachon CM et al. J. Natl. Cancer Inst. 2015 May (5)
Update on breast cancer risk prediction and prevention.
Sestak I et al. Curr. Opin. Obstet. Gynecol. 2015 Feb (1) 92-7
Sestak I et al. Curr. Opin. Obstet. Gynecol. 2015 Feb (1) 92-7
The role of genome sequencing in personalized breast cancer prevention.
Weiva Sieh, et al. Cancer Epidemiology Biomarkers and Prevention, October 23, 2014
Weiva Sieh, et al. Cancer Epidemiology Biomarkers and Prevention, October 23, 2014
Cancer genomics: Using big data to advance breast cancer risk prediction, by Srivani Ravoori, AACR blog post, Oct 23
by Srivani Ravoori, AACR blog post, Oct 23Breast Cancer Gene Expression Profiling in Practice - April 13, 2015
Cost-effectiveness of the 21-gene breast cancer assay in Mexico.
Bargalló-Rocha JE et al. Adv Ther 2015 Mar 5.
Bargalló-Rocha JE et al. Adv Ther 2015 Mar 5.
Initial trends in the use of the 21-gene recurrence score assay for patients with breast cancer in the Medicare population, 2005-2009
Dinan MA, et al. JAMA Oncology, March 2015
Dinan MA, et al. JAMA Oncology, March 2015
The value of personalizing medicine: Medical oncologists? Views on gene expression profiling in breast cancer treatment
Bombard Y, et al. The Oncologist, March 2015
Bombard Y, et al. The Oncologist, March 2015
The 21-gene recurrence score complements IBTR! Estimates in early-stage, hormone receptor-positive, HER2-normal, lymph node-negative breast cancer.
Thaker NG, et al. Springerplus 2015 36
Thaker NG, et al. Springerplus 2015 36
Oncotype DX in women and men with ER-positive, HER2-negative early stage breast cancer who are lymph node negative: A review of clinical effectiveness and guidelines
Ottawa (ON): Canadian Agency for Drugs and Technologies in Health 2014 Feb 20.
Ottawa (ON): Canadian Agency for Drugs and Technologies in Health 2014 Feb 20.
Clinical utility of gene-expression profiling in women with early breast cancer: an overview of systematic reviews.
Marrone M, et al. Genet. Med. 2014 Dec 4.
Marrone M, et al. Genet. Med. 2014 Dec 4.
[uPA/PAI-1, Oncotype DX, MammaPrint(®). Prognosis and predictive values for clinical utility in breast cancer management].
Bellocq JP, et al. Ann Pathol 2014 Oct (5) 349-51
Bellocq JP, et al. Ann Pathol 2014 Oct (5) 349-51
A study of the impact of the 21-gene breast cancer assay on the use of adjuvant chemotherapy in women with breast cancer in a Mexican public hospital.
Bargallo JE, et al. J Surg Oncol 2015 Feb (2) 203-7
Bargallo JE, et al. J Surg Oncol 2015 Feb (2) 203-7
Can mammographic and sonographic imaging features predict the Oncotype DX? recurrence score in T1 and T2, hormone receptor positive, HER2 negative and axillary lymph node negative breast cancers?
Yepes MM, et al. Breast Cancer Res. Treat. 2014 Nov (1) 117-23
Yepes MM, et al. Breast Cancer Res. Treat. 2014 Nov (1) 117-23
The impact of Oncotype DX testing on breast cancer management and chemotherapy prescribing patterns in a tertiary referral centre.
McVeigh TP, et al. Eur. J. Cancer 2014 Nov (16) 2763-70
McVeigh TP, et al. Eur. J. Cancer 2014 Nov (16) 2763-70
Genomic profile of breast cancer: cost-effectiveness analysis from the Spanish National Healthcare System perspective.
Seguí MÁ et al. Expert Rev Pharmacoecon Outcomes Res 2014 Dec (6) 889-99
Seguí MÁ et al. Expert Rev Pharmacoecon Outcomes Res 2014 Dec (6) 889-99
Societal cost-effectiveness analysis of the 21-gene assay in estrogen-receptor-positive, lymph-node-negative early-stage breast cancer in Japan.
Yamauchi H, et al. BMC Health Serv Res 2014 372
Yamauchi H, et al. BMC Health Serv Res 2014 372
Factors influencing Oncotype DX use in the management of early breast cancer: a single centre experience.
Zhu X, et al. Eur. J. Cancer 2014 Oct (15) 2544-9
Zhu X, et al. Eur. J. Cancer 2014 Oct (15) 2544-9
Diagnostic tests based on gene expression profile in breast cancer: from background to clinical use.
Zanotti L, et al. Tumour Biol. 2014 Sep (9) 8461-70
Zanotti L, et al. Tumour Biol. 2014 Sep (9) 8461-70
Breast Cancer Genomics: Where Are We Going? March 31, 2015
CDC information: New analysis of breast cancer subtypes could lead to better risk stratification
Annual report to the Nation shows that mortality and incidence for most cancers continue to decline
Annual report to the Nation shows that mortality and incidence for most cancers continue to decline
Annual report to the Nation on the status of cancer, 1975-2011, featuring incidence of breast cancer subtypes by race/ethnicity, poverty, and state
Kohler B et al. JNCI, March 30, 2015
Kohler B et al. JNCI, March 30, 2015
Breast cancer genomics from microarrays to massively parallel sequencing: paradigms and new insights.
Ng CK et al. J. Natl. Cancer Inst. 2015 (5)
Ng CK et al. J. Natl. Cancer Inst. 2015 (5)
Genomic profiling of breast cancers.
Curtis C et al. Curr. Opin. Obstet. Gynecol. 2015 Feb (1) 34-9
Curtis C et al. Curr. Opin. Obstet. Gynecol. 2015 Feb (1) 34-9
Intrinsic cancer subtypes-next steps into personalized medicine.
Santos C et al. Cell Oncol (Dordr) 2015 Jan 14.
Santos C et al. Cell Oncol (Dordr) 2015 Jan 14.
New concepts in breast cancer genomics and genetics.
Goncalves R et al. Breast Cancer Res. 2014 (5) 460
Goncalves R et al. Breast Cancer Res. 2014 (5) 460
Application of metabolomics in drug resistant breast cancer research.
Shajahan-Haq AN et al. Metabolites 2015 (1) 100-18
Shajahan-Haq AN et al. Metabolites 2015 (1) 100-18
Research progress in applying proteomics technology to explore early diagnosis biomarkers of breast cancer, lung cancer and ovarian cancer.
Luo L et al. Asian Pac. J. Cancer Prev. 2014 (20) 8529-38
Luo L et al. Asian Pac. J. Cancer Prev. 2014 (20) 8529-38
How many etiological subtypes of breast cancer: two, three, four, or more?
Anderson WF et al. J. Natl. Cancer Inst. 2014 Aug (8)
Anderson WF et al. J. Natl. Cancer Inst. 2014 Aug (8)
Computational prognostic indicators for breast cancer.
Yang X et al. Cancer Manag Res 2014 301-12
Yang X et al. Cancer Manag Res 2014 301-12
Genomic analysis of breast cancer heralds a changing treatment paradigm.
Ellis M et al. J Natl Compr Canc Netw 2014 May (5 Suppl) 750-2
Ellis M et al. J Natl Compr Canc Netw 2014 May (5 Suppl) 750-2
Triple-negative breast cancer: bridging the gap from cancer genomics to predictive biomarkers.
Davis SL et al. Ther Adv Med Oncol 2014 May (3) 88-100
Davis SL et al. Ther Adv Med Oncol 2014 May (3) 88-100
Principles and methods of integrative genomic analyses in cancer.
Kristensen VN et al. Nat. Rev. Cancer 2014 May (5) 299-313
Kristensen VN et al. Nat. Rev. Cancer 2014 May (5) 299-313
Implications of functional proteomics in breast cancer.
Chae YK et al. Oncologist 2014 Apr (4) 328-35
Chae YK et al. Oncologist 2014 Apr (4) 328-35
Genetic and epigenetic aspects of breast cancer progression and therapy.
Byler S et al. Anticancer Res. 2014 Mar (3) 1071-7
Byler S et al. Anticancer Res. 2014 Mar (3) 1071-7
The omics of triple-negative breast cancers.
Xu H et al. Clin. Chem. 2014 Jan (1) 122-33
Xu H et al. Clin. Chem. 2014 Jan (1) 122-33
Methylome sequencing in triple-negative breast cancer reveals distinct methylation clusters with prognostic value.
Stirzaker C et al. Nat Commun 2015 5899
Stirzaker C et al. Nat Commun 2015 5899
Breast cancer genomics in the deep sequencing era.
Pillar N et al. Isr. Med. Assoc. J. 2014 Dec (12) 783-4
Pillar N et al. Isr. Med. Assoc. J. 2014 Dec (12) 783-4
Celebrities: Genetics and Breast Cancer - March 30, 2015
Genetic counselors expect resurgence of 'Jolie effect'
But misinterpreted results of tests for cancer risk can result in unnecessary surgery. Erika Check Hayden, Nature News, March 30, 2015
But misinterpreted results of tests for cancer risk can result in unnecessary surgery. Erika Check Hayden, Nature News, March 30, 2015
Learning from Angelina Jolie's genetic testing for our own health, by Elizabeth Cohen, CNN, Mar 25
by Elizabeth Cohen, CNN, Mar 25Diary of a surgery, by Angelina Jolie Pitt, New York Times, Mar 24
by Angelina Jolie Pitt, New York Times, Mar 24'Jolie effect': Could her candor help save lives? By Maria Puente, USA Today, Mar 24
By Maria Puente, USA Today, Mar 24'Angelina Jolie effect': BRCA testing doubles, by Zosia Chustecka, Medscape, Sept 3
by Zosia Chustecka, Medscape, Sept 3Cancer information seeking in the digital age: Effects of Angelina Jolie's prophylactic mastectomy announcement
Noar SM, et al. Med Decis Making 2014 Oct
Noar SM, et al. Med Decis Making 2014 Oct
Celebrity disclosures and information seeking: the case of Angelina Jolie
Juthe RH, et al. Genet Med 2014 Oct
Juthe RH, et al. Genet Med 2014 Oct
The Angelina effect: immediate reach, grasp, and impact of going public.
Borzekowski DL et al. Genet Med. 2014 Jul;16(7):516-21.
Borzekowski DL et al. Genet Med. 2014 Jul;16(7):516-21.
Angelina Jolie's faulty gene: newspaper coverage of a celebrity's preventive bilateral mastectomy in Canada, the United States, and the United Kingdom.
Kamenova K et al. Genet Med. 2014 Jul;16(7):522-8.
Kamenova K et al. Genet Med. 2014 Jul;16(7):522-8.
Hereditary Breast and Ovarian Cancer: Is it time for Population Screening for BRCA Mutations? - February 17, 2015
A never-ending genetic quest. Mary-Claire King?s Pioneering gene work, from breast cancer to human rights, New York Times, Feb 9
, New York Times, Feb 9Precision medicine meets public health: population screening for BRCA1 and BRCA2.
Levy-Lahad Ephrat et al. J. Natl. Cancer Inst. 2015 Jan (1) 420
Levy-Lahad Ephrat et al. J. Natl. Cancer Inst. 2015 Jan (1) 420
Population-based screening for breast and ovarian cancer risk due to BRCA1 and BRCA2.
Gabai-Kapara Efrat et al. Proc. Natl. Acad. Sci. U.S.A. 2014 Sep 30. (39) 14205-10
Gabai-Kapara Efrat et al. Proc. Natl. Acad. Sci. U.S.A. 2014 Sep 30. (39) 14205-10
Lasker Award winner Mary-Claire King.
King Mary-Claire et al. Nat. Med. 2014 Oct (10) 1124-5
King Mary-Claire et al. Nat. Med. 2014 Oct (10) 1124-5
Population-based screening for BRCA1 and BRCA2: 2014 Lasker Award.
King Mary-Claire et al. JAMA 2014 Sep 17. (11) 1091-2
King Mary-Claire et al. JAMA 2014 Sep 17. (11) 1091-2
Cost-effectiveness of population screening for BRCA mutations in Ashkenazi Jewish women compared with family history-based testing.
Manchanda Ranjit et al. J. Natl. Cancer Inst. 2015 Jan (1) 380
Manchanda Ranjit et al. J. Natl. Cancer Inst. 2015 Jan (1) 380
Population testing for cancer predisposing BRCA1/BRCA2 mutations in the Ashkenazi-Jewish community: a randomized controlled trial.
Manchanda Ranjit et al. J. Natl. Cancer Inst. 2015 Jan (1) 379
Manchanda Ranjit et al. J. Natl. Cancer Inst. 2015 Jan (1) 379
Ovarian Cancer: Recent Genomic Insights - January 20, 2015
Identification of six new susceptibility loci for invasive epithelial ovarian cancer
Karoline B Kuchenbaecker et al. Nature Genetics, January 12, 2015
Karoline B Kuchenbaecker et al. Nature Genetics, January 12, 2015
Germline mutation in BRCA1 or BRCA2 and ten-year survival for women diagnosed with epithelial ovarian cancer.
Candido Dos Reis FJ, Clin Cancer Res. 2014 Nov 14
Candido Dos Reis FJ, Clin Cancer Res. 2014 Nov 14
Evidence for a time-dependent association between FOLR1 expression and survival from ovarian carcinoma: implications for clinical testing. An ovarian tumour tissue analysis consortium study.
Köbel M, et al. Br J Cancer. 2014 Dec 9;111(12):2297-307
Köbel M, et al. Br J Cancer. 2014 Dec 9;111(12):2297-307
New strategies in ovarian cancer: translating the molecular complexity of ovarian cancer into treatment advances.
Liu J, et al. Clin Cancer Res. 2014 Oct 15;20(20):5150-6
Liu J, et al. Clin Cancer Res. 2014 Oct 15;20(20):5150-6
Genomic classification of serous ovarian cancer with adjacent borderline differentiates RAS pathway and TP53-mutant tumors and identifies NRAS as an oncogenic driver.
Emmanuel C, et al. Clin Cancer Res. 2014 Dec 15;20(24):6618-30.
Emmanuel C, et al. Clin Cancer Res. 2014 Dec 15;20(24):6618-30.
Knowledge-driven genomic interactions: an application in ovarian cancer.
Kim D, Li R, et al. BioData Min. 2014 Sep 9;7:20
Kim D, Li R, et al. BioData Min. 2014 Sep 9;7:20
Ovarian cancer biomarkers: current state and future implications from high-throughput technologies.
Leung F, et al. Adv Clin Chem. 2014;66:25-77.
Leung F, et al. Adv Clin Chem. 2014;66:25-77.
BRCA Testing in Action: Personal Stories - December 30, 2014
Feature: Peering into my genome, by Jennifer Couzin-Frankel, Science Magazine, Dec 4
by Jennifer Couzin-Frankel, Science Magazine, Dec 4CDC blog post: Knowing BRCA changed my life, Debbie Wasserman Schultz (June, 2014)
The REAL story of Mary-Claire King, by andrea, Brave Bosom Blog Post, Nov 20
by andrea, Brave Bosom Blog Post, Nov 20Public Health Genomics in Action: Hereditary Breast and Ovarian Cancer - December 4, 2014
Hereditary breast and ovarian cancer in public health, Genetic Alliance, webinar, Nov 21
Genetic Alliance, webinar, Nov 21Recent insights
Population testing for cancer predisposing BRCA1/BRCA2 mutations in the Ashkenazi-Jewish community: A randomized controlled trial.
Ranjit Manchanda, et al. JNCI, January, 2015
Ranjit Manchanda, et al. JNCI, January, 2015
'Screen more' for cancer risk genes, by James Gallagher, BBC, Nov 30
by James Gallagher, BBC, Nov 30Breast and Ovarian Cancer Genetics: Clinical and Public Health Approaches - October 16, 2014
New CDC podcast: CDC Medscape Expert Commentary:Genetics and BRCA in Primary Care. Katherine Kolor, October 13, 2014
Katherine Kolor, October 13, 2014
[PDF 428.18 KB]CDC information: Does breast or ovarian cancer run in your family?
CDC BRCA assessment tool for women: The Know:BRCA Assessment can help you assess your risk of having a BRCA mutation. Learning your risk can help you and your doctor make important decisions for your health
CDC BRCA assessment tool for clinicians: Help women Know:BRCA
Assessing the genetic risk for BRCA-related breast or ovarian cancer in women: Recommendations from the U.S. Preventive Services Task Force
Ann Intern Med. 2014;160(4):I-16. doi:10.7326/P14-9008
Ann Intern Med. 2014;160(4):I-16. doi:10.7326/P14-9008
CDC Public health genomics implementation tool kit for health departments- check out BRCA section
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