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Genomics|Features|Opioid

Opioid Use

Opioid Use: Genomics and Reducing the Burden of Complications - March 31, 2015

CDC Info

• CDC Information Fact Sheet: Prescription Drug Overdose in the United States
• Opioid Prescription Claims Among Women of Reproductive Age — United States, 2008–2012MMWR January 23, 2015 / 64(02);37-41
• Opioid pain medications used early in pregnancy might increase risk of some birth defects
• Opioid painkiller prescribing. Where you live makes a difference,CDC Vital Signs, July 2014

CDC Information Fact Sheet: Prescription Drug Overdose in the United States

Addressing prescription opioid overdose: data support a comprehensive policy approach.
Jones Christopher M et al. JAMA 2014 Nov 5. (17) 1733-4

Individualized Hydrocodone Therapy Based on Phenotype, Pharmacogenetics, and Pharmacokinetic Dosing.
Linares Oscar A et al. Clin J Pain 2015 Jan 23.

MicroRNAs: Emerging Role in the Endogenous µ Opioid System.
Barbierato Massmo et al. CNS Neurol Disord Drug Targets 2015 (2) 239-50

Mu opioid receptor gene: new point mutations in opioid addicts.
Dinarvand Amin et al. Basic Clin Neurosci 2014 (1) 18-21

High-throughput gene expression profiling of opioid-induced alterations in discrete brain areas.
Korostynski Michal et al. Methods Mol. Biol. 2015 65-76

Pharmacogenetics of opioid response.
Somogyi A A et al. Clin. Pharmacol. Ther. 2015 Feb (2) 125-7

Opioid-induced respiratory depression: ABCB1 transporter pharmacogenetics.
Sadhasivam S et al. Pharmacogenomics J. 2015 Apr (2) 119-26

Opioid Use: Public Health and Genomic Insights - February 13, 2015

Genome-wide association study of copy number variations (CNVs) with opioid dependence.
Li Dawei et al. Neuropsychopharmacology 2015 Mar (4) 1016-26

Managing chronic pain: Opioids are often not the answer, by Dr. Francis Collins, NIH Director, Jan 27

CDC MMWR article: Opioid Prescription Claims Among Women of Reproductive Age — United States, 2008–2012
MMWR January 23, 2015 / 64(02);37-41

CDC information: Opioid pain medications used early in pregnancy might increase risk of some birth defects

Genome-wide association study of copy number variations (CNVs) with opioid dependence.
Li D, et al. Neuropsychopharmacology. 2014 Sep 27.

Genetics of opioid dependence: A review of the genetic contribution to opioid dependence.
Mistry CJ, et al. Curr Psychiatry Rev. 2014 May;10(2):156-167.

Genetic influence on methadone treatment outcomes in patients undergoing methadone maintenance treatment for opioid addiction: a pilot study.
Samaan Z, et al. Neuropsychiatr Dis Treat. 2014 Aug 19;10:1503-8

PharmGKB summary: tramadol pathway.
Gong L, et al. Pharmacogenet Genomics. 2014 Jul;24(7):374-80

Impact of ABCB1 and CYP2B6 genetic polymorphisms on methadone metabolism, dose and treatment response in patients with opioid addiction: a systematic review and meta-analysis.
Dennis BB, et al. PLoS One. 2014 Jan 29;9(1):e86114

The dopamine receptor D2 (DRD2) SNP rs1076560 is associated with opioid addiction.
Clarke TK, et al. Ann Hum Genet. 2014 Jan;78(1):33-9.

Moving toward personalized medicine in the methadone maintenance treatment program: a pilot study on the evaluation of treatment responses in Taiwan.
Lee HY,et al. Biomed Res Int. 2013;2013:741403.

Genome-wide association study of opioid dependence: multiple associations mapped to calcium and potassium pathways.
Gelernter J, et al. Biol Psychiatry. 2014 Jul 1;76(1):66-74

Genetic factors involved in risk for methamphetamine intake and sensitization.
Belknap JK, et al. Mamm Genome. 2013 Dec;24(11-12):446-58

Opioid medication prescribing to women of reproductive age, by Jennifer N. Lind, CDC Expert Commentary, Medscape, Jan 23

Painkiller Overdose: Genetic Differences in Drug Metabolism - July 5, 2014

Opioid painkiller prescribing. Where you live makes a difference, CDC Vital Signs, July 2014

CDC Vital Signs: Prescription painkiller overdoses: A growing epidemic, especially among women

CDC Vital Signs: Prescription painkiller overdoses: Use and abuse of methadone as a painkiller

Find out how opioid prescription drugs are affected by genetic differences in metabolism and which drugs have labels or dosing guidelines PharmGKB: A comprehensive resource that curates knowledge about the impact of genetic variation on drug response for clinicians and researchers

Clinical Pharmacogenetics Implementation Consortium (CPIC) guidelines for cytochrome P450 2D6 (CYP2D6) genotype and codeine therapy: 2014 Update- 2014 supplement  [PDF 293.44 KB]

Podcast: New Codeine guideline and more help with pharmacogenomics

Impact of ABCB1 and CYP2B6 genetic polymorphisms on methadone metabolism, dose and treatment response in patients with opioid addiction: A systematic review and meta-analysis.
Dennis BB, et al.  PLoS One 2014 9 (1): 1.

Genome-wide association study of opioid dependence: Multiple associations mapped to calcium and potassium pathways.
Gelernter J, et al. Biol Psychiatry. 2014 Jul 1;76(1):66-74.

Find out genetic conditions and tests associated with opioid use and dependence, from the NIH Genetic Testing Registry